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Atomistry » Calcium » PDB 5l0u-5lh8 » 5l30 » |
Calcium in PDB 5l30: Factor Viia in Complex with the Inhibitor (2R,15R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-4,15,17-Trimethyl-7-[1-(1H-Tetrazol-5- Yl)Cyclopropyl]-13-Oxa-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa- 1(18),6(21),7,9,16,19-Hexaene-3,12-DioneEnzymatic activity of Factor Viia in Complex with the Inhibitor (2R,15R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-4,15,17-Trimethyl-7-[1-(1H-Tetrazol-5- Yl)Cyclopropyl]-13-Oxa-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa- 1(18),6(21),7,9,16,19-Hexaene-3,12-Dione
All present enzymatic activity of Factor Viia in Complex with the Inhibitor (2R,15R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-4,15,17-Trimethyl-7-[1-(1H-Tetrazol-5- Yl)Cyclopropyl]-13-Oxa-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa- 1(18),6(21),7,9,16,19-Hexaene-3,12-Dione:
3.4.21.21; Protein crystallography data
The structure of Factor Viia in Complex with the Inhibitor (2R,15R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-4,15,17-Trimethyl-7-[1-(1H-Tetrazol-5- Yl)Cyclopropyl]-13-Oxa-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa- 1(18),6(21),7,9,16,19-Hexaene-3,12-Dione, PDB code: 5l30
was solved by
A.Wei,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Calcium Binding Sites:
The binding sites of Calcium atom in the Factor Viia in Complex with the Inhibitor (2R,15R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-4,15,17-Trimethyl-7-[1-(1H-Tetrazol-5- Yl)Cyclopropyl]-13-Oxa-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa- 1(18),6(21),7,9,16,19-Hexaene-3,12-Dione
(pdb code 5l30). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Factor Viia in Complex with the Inhibitor (2R,15R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-4,15,17-Trimethyl-7-[1-(1H-Tetrazol-5- Yl)Cyclopropyl]-13-Oxa-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa- 1(18),6(21),7,9,16,19-Hexaene-3,12-Dione, PDB code: 5l30: Calcium binding site 1 out of 1 in 5l30Go back to Calcium Binding Sites List in 5l30
Calcium binding site 1 out
of 1 in the Factor Viia in Complex with the Inhibitor (2R,15R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-4,15,17-Trimethyl-7-[1-(1H-Tetrazol-5- Yl)Cyclopropyl]-13-Oxa-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa- 1(18),6(21),7,9,16,19-Hexaene-3,12-Dione
Mono view Stereo pair view
Reference:
V.U.Ladziata,
P.W.Glunz,
Y.Zou,
X.Zhang,
W.Jiang,
S.Jacutin-Porte,
D.L.Cheney,
A.Wei,
J.M.Luettgen,
T.M.Harper,
P.C.Wong,
D.Seiffert,
R.R.Wexler,
E.S.Priestley.
Synthesis and P1' Sar Exploration of Potent Macrocyclic Tissue Factor-Factor Viia Inhibitors. Bioorg.Med.Chem.Lett. V. 26 5051 2016.
Page generated: Sat Dec 12 05:35:08 2020
ISSN: ESSN 1464-3405 PubMed: 27612545 DOI: 10.1016/J.BMCL.2016.08.088 |
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