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Calcium in PDB 5mnq: Cationic Trypsin in Complex with A Derivative of N-Amidinopiperidine

Enzymatic activity of Cationic Trypsin in Complex with A Derivative of N-Amidinopiperidine

All present enzymatic activity of Cationic Trypsin in Complex with A Derivative of N-Amidinopiperidine:
3.4.21.4;

Protein crystallography data

The structure of Cationic Trypsin in Complex with A Derivative of N-Amidinopiperidine, PDB code: 5mnq was solved by J.Schiebel, K.Ngo, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.35 / 1.34
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 59.893, 64.076, 69.435, 90.00, 90.00, 90.00
R / Rfree (%) 13.7 / 17.1

Calcium Binding Sites:

The binding sites of Calcium atom in the Cationic Trypsin in Complex with A Derivative of N-Amidinopiperidine (pdb code 5mnq). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Cationic Trypsin in Complex with A Derivative of N-Amidinopiperidine, PDB code: 5mnq:

Calcium binding site 1 out of 1 in 5mnq

Go back to Calcium Binding Sites List in 5mnq
Calcium binding site 1 out of 1 in the Cationic Trypsin in Complex with A Derivative of N-Amidinopiperidine


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cationic Trypsin in Complex with A Derivative of N-Amidinopiperidine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca301

b:13.8
occ:1.00
OE1 A:GLU70 2.3 13.8 1.0
O A:VAL75 2.3 17.5 1.0
O A:ASN72 2.3 15.3 1.0
OE2 A:GLU80 2.3 13.9 1.0
O A:HOH475 2.4 14.6 1.0
O A:HOH410 2.4 14.6 1.0
HG2 A:GLU80 3.3 16.1 1.0
CD A:GLU80 3.3 12.4 1.0
CD A:GLU70 3.4 12.3 1.0
C A:VAL75 3.5 17.5 1.0
HA A:VAL76 3.5 19.7 1.0
C A:ASN72 3.5 14.7 1.0
HA A:ILE73 3.5 16.7 1.0
H A:GLU77 3.5 20.7 1.0
HG3 A:GLU80 3.5 16.1 1.0
H A:VAL75 3.6 22.5 1.0
CG A:GLU80 3.6 13.4 1.0
HG3 A:GLU77 3.6 24.0 1.0
OE2 A:GLU70 3.8 13.4 1.0
H A:ASP71 3.9 16.0 1.0
HA A:GLU70 4.0 14.2 1.0
HB3 A:ASN72 4.1 20.1 1.0
HB2 A:GLU77 4.2 23.1 1.0
N A:GLU77 4.2 17.3 1.0
CA A:ILE73 4.2 13.9 1.0
CA A:VAL76 4.2 16.4 1.0
N A:VAL76 4.2 17.0 1.0
N A:VAL75 4.2 18.7 1.0
N A:ILE73 4.3 14.3 1.0
H A:ASN72 4.3 18.1 1.0
OE1 A:GLU77 4.3 18.7 1.0
O A:HOH405 4.3 18.4 1.0
N A:ASN72 4.4 15.1 1.0
CA A:ASN72 4.4 15.1 1.0
C A:ILE73 4.5 15.1 1.0
CG A:GLU77 4.5 20.0 1.0
CA A:VAL75 4.5 18.8 1.0
OE1 A:GLU80 4.5 14.1 1.0
HB3 A:GLU70 4.5 13.7 1.0
N A:ASP71 4.6 13.3 1.0
CG A:GLU70 4.7 11.7 1.0
C A:VAL76 4.7 17.4 1.0
HB A:VAL75 4.7 26.1 1.0
CB A:GLU77 4.7 19.2 1.0
O A:HOH598 4.8 29.4 1.0
CB A:ASN72 4.8 16.8 1.0
CA A:GLU70 4.8 11.8 1.0
N A:ASN74 4.8 16.8 1.0
CB A:GLU70 4.8 11.4 1.0
O A:ILE73 4.8 16.6 1.0
CD A:GLU77 4.9 20.5 1.0
H A:ASN74 4.9 20.2 1.0

Reference:

J.Schiebel, R.Gaspari, T.Wulsdorf, K.Ngo, C.Sohn, T.E.Schrader, A.Cavalli, A.Ostermann, A.Heine, G.Klebe. Intriguing Role of Water in Protein-Ligand Binding Studied By Neutron Crystallography on Trypsin Complexes. Nat Commun V. 9 3559 2018.
ISSN: ESSN 2041-1723
PubMed: 30177695
DOI: 10.1038/S41467-018-05769-2
Page generated: Mon Jul 15 08:31:36 2024

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