Atomistry » Calcium » PDB 5odu-5oyl » 5onq
Atomistry »
  Calcium »
    PDB 5odu-5oyl »
      5onq »

Calcium in PDB 5onq: Alzheimer'S Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd- Substituted Thermolysin

Enzymatic activity of Alzheimer'S Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd- Substituted Thermolysin

All present enzymatic activity of Alzheimer'S Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd- Substituted Thermolysin:
3.4.24.27;

Protein crystallography data

The structure of Alzheimer'S Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd- Substituted Thermolysin, PDB code: 5onq was solved by J.P.Leite, L.Gales, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.97 / 1.17
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 93.488, 93.488, 129.558, 90.00, 90.00, 120.00
R / Rfree (%) 16.3 / 17.2

Other elements in 5onq:

The structure of Alzheimer'S Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd- Substituted Thermolysin also contains other interesting chemical elements:

Cadmium (Cd) 4 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Alzheimer'S Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd- Substituted Thermolysin (pdb code 5onq). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Alzheimer'S Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd- Substituted Thermolysin, PDB code: 5onq:

Calcium binding site 1 out of 1 in 5onq

Go back to Calcium Binding Sites List in 5onq
Calcium binding site 1 out of 1 in the Alzheimer'S Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd- Substituted Thermolysin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Alzheimer'S Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd- Substituted Thermolysin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca401

b:14.0
occ:1.00
 O A:ILE197 2.3 17.2 1.0
O A:TYR193 2.4 12.7 1.0
OD1 A:ASP200 2.4 15.6 1.0
O A:HOH726 2.4 20.7 1.0
O A:HOH630 2.4 15.2 1.0
OG1 A:THR194 2.4 14.8 1.0
O A:THR194 2.4 15.7 1.0
C A:THR194 3.2 14.8 1.0
C A:TYR193 3.3 11.8 1.0
CG A:ASP200 3.4 14.8 1.0
CB A:THR194 3.4 15.2 1.0
C A:ILE197 3.5 20.6 1.0
CA A:THR194 3.7 14.4 1.0
OD2 A:ASP200 3.8 16.6 1.0
N A:THR194 3.9 12.5 1.0
CA A:ILE197 4.2 19.1 1.0
N A:ILE197 4.3 21.6 1.0
O A:HOH664 4.3 36.6 1.0
CB A:ILE197 4.3 19.8 1.0
N A:PRO195 4.3 16.3 1.0
N A:SER198 4.5 22.3 1.0
O A:ASP200 4.5 15.2 1.0
CA A:TYR193 4.6 12.3 1.0
O A:HOH649 4.6 36.4 1.0
CD2 A:TYR193 4.6 15.0 1.0
N A:ASP200 4.6 17.5 1.0
O A:GLU190 4.7 12.3 1.0
CA A:SER198 4.7 24.6 1.0
CB A:TYR193 4.7 12.8 1.0
CA A:PRO195 4.7 16.8 1.0
CG2 A:THR194 4.7 16.2 1.0
CB A:ASP200 4.7 16.3 1.0
O A:HOH792 4.8 28.9 1.0
C A:ASP200 4.8 13.8 1.0
CG2 A:ILE197 4.9 19.2 1.0
C A:SER198 5.0 23.8 1.0
CA A:ASP200 5.0 17.3 1.0
CG A:TYR193 5.0 12.6 1.0
N A:GLY199 5.0 19.2 1.0
C A:PRO195 5.0 19.8 1.0

Reference:

J.P.Leite, L.Gales. Alzheimer'S A BETA1-40PEPTIDE Degradation By Thermolysin: Evidence of Inhibition By A C-Terminal A Beta Product. Febs Lett. V. 593 128 2019.
ISSN: ISSN 1873-3468
PubMed: 30403288
DOI: 10.1002/1873-3468.13285
Page generated: Mon Jul 15 09:51:46 2024

Last articles

Zn in 9J0N
Zn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy