Calcium in PDB 5oyb: Structure of Calcium-Bound MTMEM16A Chloride Channel at 3.75 A Resolution

The binding sites of Calcium atom in the Structure of Calcium-Bound MTMEM16A Chloride Channel at 3.75 A Resolution (pdb code 5oyb). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Structure of Calcium-Bound MTMEM16A Chloride Channel at 3.75 A Resolution, PDB code: 5oyb:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Structure of Calcium-Bound MTMEM16A Chloride Channel at 3.75 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Calcium-Bound MTMEM16A Chloride Channel at 3.75 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1001 b:72.3 occ:1.00 OE2 A:GLU734 1.8 72.3 1.0 OE2 A:GLU702 1.8 79.8 1.0 OE2 A:GLU654 2.4 0.7 1.0 CD A:GLU702 2.6 81.5 1.0 OE1 A:GLU702 2.7 83.0 1.0 OD1 A:ASP738 2.8 65.3 1.0 OE1 A:GLU654 2.9 1.0 1.0 CD A:GLU654 3.0 0.7 1.0 CD A:GLU734 3.0 70.7 1.0 OE1 A:GLU705 3.3 0.3 1.0 OD2 A:ASP738 3.4 64.6 1.0 CG A:ASP738 3.5 64.7 1.0 CA A:CA1002 3.7 78.0 1.0 CG A:GLU734 3.8 66.8 1.0 OE1 A:GLU734 3.9 71.2 1.0 CG A:GLU702 4.0 76.5 1.0 CD A:GLU705 4.4 0.3 1.0 CG A:GLU654 4.5 0.8 1.0 OE2 A:GLU705 4.9 0.7 1.0 CB A:ASP738 4.9 62.9 1.0 NZ A:LYS741 4.9 87.8 1.0

Calcium binding site 2 out of 4 in the Structure of Calcium-Bound MTMEM16A Chloride Channel at 3.75 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Calcium-Bound MTMEM16A Chloride Channel at 3.75 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1002 b:78.0 occ:1.00 OE2 A:GLU705 2.1 0.7 1.0 OE1 A:GLU734 2.1 71.2 1.0 OE1 A:GLU705 2.5 0.3 1.0 OE2 A:GLU734 2.6 72.3 1.0 CD A:GLU705 2.6 0.3 1.0 CD A:GLU734 2.7 70.7 1.0 OD1 A:ASN651 2.9 93.3 1.0 OE1 A:GLU654 3.0 1.0 1.0 CA A:CA1001 3.7 72.3 1.0 CG A:ASN651 4.0 93.2 1.0 CG A:GLU705 4.1 92.1 1.0 CG A:GLU734 4.1 66.8 1.0 CD A:GLU654 4.2 0.7 1.0 CB A:ASN650 4.2 0.8 1.0 CG A:ASN650 4.2 0.8 1.0 OD1 A:ASN650 4.4 0.5 1.0 C A:ASN650 4.5 95.2 1.0 N A:ASN651 4.5 92.7 1.0 O A:ASN650 4.6 98.2 1.0 ND2 A:ASN650 4.6 0.1 1.0 O A:GLN646 4.6 85.5 1.0 OD1 A:ASN730 4.7 78.4 1.0 CA A:ASN651 4.7 93.4 1.0 OE2 A:GLU654 4.7 0.7 1.0 ND2 A:ASN651 4.8 92.7 1.0 CB A:GLU734 4.9 62.5 1.0 CB A:ASN651 5.0 93.3 1.0 CB A:GLU705 5.0 78.4 1.0

Calcium binding site 3 out of 4 in the Structure of Calcium-Bound MTMEM16A Chloride Channel at 3.75 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structure of Calcium-Bound MTMEM16A Chloride Channel at 3.75 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1001 b:72.3 occ:1.00 OE2 B:GLU734 1.8 72.3 1.0 OE2 B:GLU702 1.8 79.8 1.0 OE2 B:GLU654 2.4 0.7 1.0 CD B:GLU702 2.6 81.5 1.0 OE1 B:GLU702 2.7 83.0 1.0 OD1 B:ASP738 2.8 65.3 1.0 OE1 B:GLU654 2.9 1.0 1.0 CD B:GLU654 3.0 0.7 1.0 CD B:GLU734 3.0 70.7 1.0 OE1 B:GLU705 3.3 0.3 1.0 OD2 B:ASP738 3.4 64.6 1.0 CG B:ASP738 3.5 64.7 1.0 CA B:CA1002 3.7 78.0 1.0 CG B:GLU734 3.8 66.8 1.0 OE1 B:GLU734 3.9 71.2 1.0 CG B:GLU702 4.0 76.5 1.0 CD B:GLU705 4.4 0.3 1.0 CG B:GLU654 4.5 0.8 1.0 OE2 B:GLU705 4.9 0.7 1.0 CB B:ASP738 4.9 62.9 1.0 NZ B:LYS741 4.9 87.8 1.0

Calcium binding site 4 out of 4 in the Structure of Calcium-Bound MTMEM16A Chloride Channel at 3.75 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structure of Calcium-Bound MTMEM16A Chloride Channel at 3.75 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1002 b:78.0 occ:1.00 OE2 B:GLU705 2.1 0.7 1.0 OE1 B:GLU734 2.1 71.2 1.0 OE1 B:GLU705 2.5 0.3 1.0 OE2 B:GLU734 2.6 72.3 1.0 CD B:GLU705 2.6 0.3 1.0 CD B:GLU734 2.7 70.7 1.0 OD1 B:ASN651 2.9 93.3 1.0 OE1 B:GLU654 3.0 1.0 1.0 CA B:CA1001 3.7 72.3 1.0 CG B:ASN651 4.0 93.2 1.0 CG B:GLU705 4.1 92.1 1.0 CG B:GLU734 4.1 66.8 1.0 CD B:GLU654 4.2 0.7 1.0 CB B:ASN650 4.2 0.8 1.0 CG B:ASN650 4.2 0.8 1.0 OD1 B:ASN650 4.4 0.5 1.0 C B:ASN650 4.5 95.2 1.0 N B:ASN651 4.5 92.7 1.0 O B:ASN650 4.6 98.2 1.0 ND2 B:ASN650 4.6 0.1 1.0 O B:GLN646 4.6 85.5 1.0 OD1 B:ASN730 4.7 78.4 1.0 CA B:ASN651 4.7 93.4 1.0 OE2 B:GLU654 4.7 0.7 1.0 ND2 B:ASN651 4.8 92.7 1.0 CB B:GLU734 4.9 62.5 1.0 CB B:ASN651 5.0 93.3 1.0

C.Paulino, V.Kalienkova, A.K.M.Lam, Y.Neldner, R.Dutzler. Activation Mechanism of the Calcium-Activated Chloride Channel TMEM16A Revealed By Cryo-Em. Nature V. 552 421 2017.
ISSN: ESSN 1476-4687
PubMed: 29236691
DOI: 10.1038/NATURE24652