Calcium in PDB 5vxz: High-Affinity Axl Decoy Receptor

All present enzymatic activity of High-Affinity Axl Decoy Receptor:
2.7.10.1;

The structure of High-Affinity Axl Decoy Receptor, PDB code: 5vxz was solved by I.I.Mathrews, S.Kapur, M.S.Kariolis, J.R.Cochran, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.61 / 2.30
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	77.220, 80.470, 249.650, 90.00, 90.00, 90.00
R / Rfree (%)	19.8 / 24.7

The structure of High-Affinity Axl Decoy Receptor also contains other interesting chemical elements:

Chlorine

(Cl)

3 atoms

The binding sites of Calcium atom in the High-Affinity Axl Decoy Receptor (pdb code 5vxz). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the High-Affinity Axl Decoy Receptor, PDB code: 5vxz:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the High-Affinity Axl Decoy Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of High-Affinity Axl Decoy Receptor within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca703 b:58.2 occ:1.00 OD2 A:ASP656 2.0 58.7 1.0 O A:GLU331 2.3 58.0 1.0 O A:HOH809 2.3 61.3 1.0 OD1 A:ASP329 2.4 57.4 1.0 O A:HOH822 2.5 64.2 1.0 O A:ARG440 2.5 52.7 1.0 OD2 A:ASP329 2.6 56.0 1.0 CG A:ASP329 2.8 57.0 1.0 CG A:ASP656 3.2 58.5 1.0 C A:GLU331 3.5 62.4 1.0 C A:ARG440 3.6 55.7 1.0 CB A:ASP656 3.9 55.7 1.0 CE1 A:HIS668 4.0 61.1 1.0 OD1 A:ASP656 4.2 56.2 1.0 CA A:LEU441 4.3 54.7 1.0 N A:GLU331 4.3 65.1 1.0 CB A:ASP329 4.3 59.3 1.0 CA A:GLU331 4.3 64.8 1.0 ND1 A:HIS668 4.4 62.4 1.0 N A:LEU441 4.4 52.9 1.0 N A:GLY332 4.5 64.6 1.0 CB A:GLU331 4.6 67.7 1.0 CA A:ARG440 4.6 62.3 1.0 CB A:ARG440 4.7 64.1 1.0 CA A:GLY332 4.7 62.6 1.0 CG A:GLU331 4.8 68.6 1.0 O A:ASN438 4.8 62.1 1.0 N A:ASP442 4.9 54.8 1.0 OD2 A:ASP654 4.9 58.0 1.0 N A:ARG440 4.9 64.0 1.0 NE2 A:HIS668 5.0 62.6 1.0

Calcium binding site 2 out of 2 in the High-Affinity Axl Decoy Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of High-Affinity Axl Decoy Receptor within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca703 b:35.3 occ:1.00 OD2 B:ASP656 2.1 31.5 1.0 O B:GLU331 2.2 31.0 1.0 O B:ARG440 2.4 32.2 1.0 OD2 B:ASP329 2.4 30.2 1.0 O B:HOH843 2.5 31.5 1.0 O B:HOH847 2.5 37.7 1.0 OD1 B:ASP329 2.6 31.0 1.0 CG B:ASP329 2.8 30.9 1.0 CG B:ASP656 3.3 29.9 1.0 C B:GLU331 3.4 30.2 1.0 C B:ARG440 3.6 34.6 1.0 CB B:ASP656 4.0 29.1 1.0 NE2 B:HIS668 4.1 34.3 1.0 N B:GLU331 4.2 29.7 1.0 CA B:GLU331 4.2 30.0 1.0 OD1 B:ASP656 4.3 27.3 1.0 CA B:LEU441 4.3 34.7 1.0 CD2 B:HIS668 4.3 35.7 1.0 N B:LEU441 4.4 33.9 1.0 CB B:ASP329 4.4 31.0 1.0 O B:HOH871 4.4 36.0 1.0 N B:GLY332 4.5 29.4 1.0 CB B:GLU331 4.5 30.2 1.0 CA B:ARG440 4.5 36.0 1.0 CB B:ARG440 4.6 38.1 1.0 O B:ASN438 4.6 33.7 1.0 CA B:GLY332 4.7 29.1 1.0 OD1 B:ASP654 4.8 35.9 1.0 N B:ARG440 4.9 40.2 1.0 N B:ASP442 4.9 32.7 1.0 CD1 B:LEU441 4.9 39.7 1.0

M.S.Kariolis, Y.R.Miao, A.Diep, S.E.Nash, M.M.Olcina, D.Jiang, D.S.Jones, S.Kapur, I.I.Mathews, A.C.Koong, E.B.Rankin, J.R.Cochran, A.J.Giaccia. Inhibition of the GAS6/Axl Pathway Augments the Efficacy of Chemotherapies. J. Clin. Invest. V. 127 183 2017.
ISSN: ISSN 1558-8238
PubMed: 27893463
DOI: 10.1172/JCI85610