Calcium in PDB 6ale: A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model

The structure of A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model, PDB code: 6ale was solved by Y.W.Nam, M.Zhang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.19 / 2.50
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	76.653, 66.913, 64.712, 90.00, 92.47, 90.00
R / Rfree (%)	18.8 / 25.5

The structure of A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Calcium atom in the A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model (pdb code 6ale). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model, PDB code: 6ale:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model within 5.0Å range: probe atom residue distance (Å) B Occ R:Ca1001 b:62.0 occ:1.00 O R:THR26 2.3 43.6 1.0 OD1 R:ASP24 2.3 67.4 1.0 OD1 R:ASP20 2.3 62.3 1.0 OD1 R:ASP22 2.4 72.6 1.0 OE1 R:GLU31 2.5 56.9 1.0 OE2 R:GLU31 2.5 58.3 1.0 CD R:GLU31 2.8 55.2 1.0 CG R:ASP22 3.1 71.5 1.0 OD2 R:ASP22 3.2 72.8 1.0 CG R:ASP24 3.4 68.0 1.0 CG R:ASP20 3.5 64.1 1.0 C R:THR26 3.5 46.6 1.0 OG1 R:THR26 4.1 59.0 1.0 OD2 R:ASP20 4.2 69.6 1.0 CB R:ASP24 4.2 67.9 1.0 CG R:GLU31 4.2 47.8 1.0 OD2 R:ASP24 4.2 68.1 1.0 N R:ASP24 4.3 64.6 1.0 N R:THR26 4.3 49.7 1.0 N R:ASP22 4.4 70.0 1.0 CA R:ASP20 4.4 56.6 1.0 CB R:ASP22 4.4 69.2 1.0 CA R:THR26 4.4 50.3 1.0 N R:ILE27 4.5 41.5 1.0 CB R:ASP20 4.5 59.5 1.0 C R:ASP20 4.6 60.4 1.0 CA R:ILE27 4.6 38.8 1.0 N R:LYS21 4.6 71.3 1.0 N R:GLY23 4.7 77.7 1.0 N R:THR28 4.7 37.6 1.0 CA R:ASP24 4.7 65.9 1.0 CG2 R:THR28 4.8 39.2 1.0 CA R:ASP22 4.9 71.9 1.0 OG1 R:THR28 4.9 39.9 1.0 CB R:THR26 4.9 53.1 1.0 N R:GLY25 4.9 53.6 1.0 C R:ASP24 5.0 61.0 1.0

Calcium binding site 2 out of 2 in the A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model within 5.0Å range: probe atom residue distance (Å) B Occ R:Ca1002 b:57.7 occ:1.00 O R:THR62 2.4 56.6 1.0 OD1 R:ASN60 2.5 66.4 1.0 OE2 R:GLU67 2.5 63.9 1.0 OE1 R:GLU67 2.5 61.8 1.0 OD1 R:ASP58 2.8 74.5 1.0 CD R:GLU67 2.8 64.5 1.0 OD1 R:ASP56 3.2 61.2 1.0 OD2 R:ASP58 3.2 72.7 1.0 CG R:ASN60 3.3 68.4 1.0 CG R:ASP58 3.4 73.0 1.0 OD2 R:ASP64 3.4 94.0 1.0 ND2 R:ASN60 3.5 72.5 1.0 C R:THR62 3.5 52.3 1.0 N R:ASP64 4.0 63.7 1.0 CG R:ASP64 4.1 89.8 1.0 CA R:ILE63 4.2 49.3 1.0 CG R:ASP56 4.3 66.5 1.0 OG1 R:THR62 4.3 52.5 1.0 N R:ILE63 4.3 47.7 1.0 CG R:GLU67 4.3 64.7 1.0 C R:ILE63 4.4 51.3 1.0 N R:THR62 4.6 54.1 1.0 CA R:THR62 4.6 50.1 1.0 CB R:ASP64 4.6 82.0 1.0 CB R:ASN60 4.7 67.4 1.0 OD1 R:ASP64 4.7 91.0 1.0 CB R:ASP58 4.8 73.9 1.0 N R:ASN60 4.9 62.7 1.0 N R:ASP58 4.9 74.3 1.0 OD2 R:ASP56 4.9 64.6 1.0 CA R:ASP64 4.9 73.1 1.0

Y.W.Nam, M.Zhang. Calcium-Calmodulin Complexed with the Calmodulin Binding Domain From A Mutant Small Conductance Potassium Channel and NS309 To Be Published.