Calcium in PDB 6am3: Regulator of G Protein Signaling (Rgs) 17 in Complex with CA2+

The structure of Regulator of G Protein Signaling (Rgs) 17 in Complex with CA2+, PDB code: 6am3 was solved by M.Sieng, A.M.Lyon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 1.53
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	39.571, 59.295, 65.337, 90.00, 100.60, 90.00
R / Rfree (%)	20.3 / 22.5

The binding sites of Calcium atom in the Regulator of G Protein Signaling (Rgs) 17 in Complex with CA2+ (pdb code 6am3). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Regulator of G Protein Signaling (Rgs) 17 in Complex with CA2+, PDB code: 6am3:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Regulator of G Protein Signaling (Rgs) 17 in Complex with CA2+


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Regulator of G Protein Signaling (Rgs) 17 in Complex with CA2+ within 5.0Å range: probe atom residue distance (Å) B Occ X:Ca301 b:14.2 occ:1.00 O X:TYR106 2.3 13.9 1.0 O X:HOH502 2.3 20.8 1.0 O X:HOH495 2.4 18.1 1.0 OE2 X:GLU109 2.5 13.1 1.0 OE1 X:GLU109 2.5 12.5 1.0 O X:HOH503 2.6 34.0 1.0 CD X:GLU109 2.8 12.5 1.0 C X:TYR106 3.4 14.0 1.0 CB X:TYR106 4.1 16.5 1.0 CA X:TYR106 4.3 15.0 1.0 CG X:GLU109 4.3 12.0 1.0 N X:SER107 4.3 13.2 1.0 O X:HOH416 4.4 33.4 1.0 CA X:SER107 4.4 12.6 1.0 O X:HOH433 4.5 14.6 1.0 OE1 X:GLU108 4.7 14.2 1.0 O X:HOH467 4.7 31.3 1.0 O X:HOH504 4.9 30.8 1.0 CB X:GLU109 5.0 11.7 1.0

Calcium binding site 2 out of 4 in the Regulator of G Protein Signaling (Rgs) 17 in Complex with CA2+


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Regulator of G Protein Signaling (Rgs) 17 in Complex with CA2+ within 5.0Å range: probe atom residue distance (Å) B Occ X:Ca302 b:12.6 occ:1.00 O X:GLN124 2.3 20.6 1.0 O X:HOH518 2.4 21.3 1.0 C X:GLN124 3.5 20.4 1.0 CA X:GLN124 4.1 20.5 1.0 CB X:GLN124 4.3 22.1 1.0 N X:LYS126 4.4 19.3 1.0 N X:ASN125 4.5 20.2 1.0 CD1 X:ILE129 4.6 17.1 1.0 CA X:ASN125 4.8 20.5 1.0 C X:ASN125 4.8 19.0 1.0 O X:HOH512 4.8 31.8 1.0 CA X:LYS126 4.9 18.2 1.0 CB X:LYS126 4.9 18.9 1.0

Calcium binding site 3 out of 4 in the Regulator of G Protein Signaling (Rgs) 17 in Complex with CA2+


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Regulator of G Protein Signaling (Rgs) 17 in Complex with CA2+ within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca301 b:14.8 occ:1.00 O A:HOH486 2.3 20.3 1.0 O A:TYR106 2.3 14.4 1.0 O A:HOH491 2.4 14.9 1.0 OE2 A:GLU109 2.4 12.9 1.0 OE1 A:GLU109 2.5 12.4 1.0 O A:HOH490 2.7 35.7 1.0 CD A:GLU109 2.8 12.4 1.0 C A:TYR106 3.4 14.4 1.0 CB A:TYR106 4.2 16.8 1.0 CG A:GLU109 4.2 11.9 1.0 CA A:TYR106 4.3 15.3 1.0 N A:SER107 4.3 13.6 1.0 CA A:SER107 4.4 13.0 1.0 O A:HOH439 4.4 15.0 1.0 O A:HOH488 4.6 39.1 1.0 OE1 A:GLU108 4.7 14.4 1.0 CB A:GLU109 5.0 11.7 1.0 O A:HOH503 5.0 33.2 1.0

Calcium binding site 4 out of 4 in the Regulator of G Protein Signaling (Rgs) 17 in Complex with CA2+


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Regulator of G Protein Signaling (Rgs) 17 in Complex with CA2+ within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca302 b:11.8 occ:1.00 O A:HOH420 2.3 17.6 1.0 O A:ILE143 2.3 16.2 1.0 OE2 A:GLU148 2.3 15.3 1.0 O A:HOH522 2.4 15.3 1.0 C A:ILE143 3.4 15.8 1.0 CD A:GLU148 3.5 14.6 1.0 CA A:ILE143 4.0 15.1 1.0 OE1 A:GLU148 4.1 14.9 1.0 N A:LEU144 4.4 16.1 1.0 CB A:ILE143 4.5 16.0 1.0 O A:HOH541 4.5 40.3 1.0 O A:SER145 4.5 15.9 1.0 CB A:GLU148 4.6 13.6 1.0 O A:HOH533 4.6 33.6 1.0 CG A:GLU148 4.6 13.6 1.0 CA A:LEU144 4.7 17.1 1.0 C A:LEU144 5.0 16.8 1.0

M.Sieng, M.P.Hayes, J.B.O'brien, C.Andrew Fowler, J.C.Houtman, D.L.Roman, A.M.Lyon. High-Resolution Structure of RGS17 Suggests A Role For CA2+in Promoting the Gtpase-Activating Protein Activity By Rz Subfamily Members. J.Biol.Chem. V. 294 8148 2019.
ISSN: ESSN 1083-351X
PubMed: 30940727
DOI: 10.1074/JBC.RA118.006059