Calcium in PDB 6bdz: ADAM10 Extracellular Domain Bound By the 11G2 Fab

Enzymatic activity of ADAM10 Extracellular Domain Bound By the 11G2 Fab

All present enzymatic activity of ADAM10 Extracellular Domain Bound By the 11G2 Fab:
3.4.24.81;

Protein crystallography data

The structure of ADAM10 Extracellular Domain Bound By the 11G2 Fab, PDB code: 6bdz was solved by T.C.M.Seegar, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.79 / 3.10
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 79.230, 97.580, 262.720, 90.00, 90.00, 90.00
R / Rfree (%) 26.1 / 31.7

Other elements in 6bdz:

The structure of ADAM10 Extracellular Domain Bound By the 11G2 Fab also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the ADAM10 Extracellular Domain Bound By the 11G2 Fab (pdb code 6bdz). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the ADAM10 Extracellular Domain Bound By the 11G2 Fab, PDB code: 6bdz:

Calcium binding site 1 out of 1 in 6bdz

Go back to Calcium Binding Sites List in 6bdz
Calcium binding site 1 out of 1 in the ADAM10 Extracellular Domain Bound By the 11G2 Fab


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of ADAM10 Extracellular Domain Bound By the 11G2 Fab within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca704

b:62.6
occ:1.00
OD2 A:ASP472 2.2 56.2 1.0
OE1 A:GLU466 2.2 64.2 1.0
O A:ILE459 2.2 63.1 1.0
OD1 A:ASN462 2.3 67.4 1.0
OE2 A:GLU469 2.4 52.6 1.0
CD A:GLU466 3.0 67.2 1.0
CD A:GLU469 3.1 43.6 1.0
OE1 A:GLU469 3.1 42.3 1.0
OE2 A:GLU466 3.3 86.7 1.0
CG A:ASN462 3.3 65.5 1.0
O A:MET464 3.4 59.3 1.0
CG A:ASP472 3.4 49.4 1.0
C A:ILE459 3.4 79.6 1.0
CA A:CYS460 3.7 63.8 1.0
N A:GLY461 3.8 59.1 1.0
ND2 A:ASN462 3.9 87.2 1.0
N A:CYS460 4.0 87.8 1.0
N A:ASN462 4.0 65.1 1.0
CB A:ASP472 4.2 44.5 1.0
C A:CYS460 4.2 65.8 1.0
OD1 A:ASP472 4.2 47.2 1.0
CG A:GLU466 4.3 63.5 1.0
CB A:ASN462 4.4 56.4 1.0
CG A:GLU469 4.5 38.6 1.0
C A:MET464 4.5 65.9 1.0
CA A:ILE459 4.6 86.8 1.0
N A:ILE459 4.6 85.6 1.0
CB A:GLU466 4.7 77.5 1.0
CA A:ASN462 4.8 57.0 1.0
N A:GLU466 4.8 55.2 1.0
SG A:CYS495 4.8 39.3 1.0
CG1 A:ILE459 4.8 54.9 1.0
CB A:CYS460 4.9 33.6 1.0
N A:MET464 4.9 72.5 1.0
CA A:GLY461 4.9 68.2 1.0
C A:GLY461 5.0 61.4 1.0
C A:PRO458 5.0 91.6 1.0

Reference:

T.C.M.Seegar, L.B.Killingsworth, N.Saha, P.A.Meyer, D.Patra, B.Zimmerman, P.W.Janes, E.Rubinstein, D.B.Nikolov, G.Skiniotis, A.C.Kruse, S.C.Blacklow. Structural Basis For Regulated Proteolysis By the Alpha-Secretase ADAM10. Cell V. 171 1638 2017.
ISSN: ISSN 1097-4172
PubMed: 29224781
DOI: 10.1016/J.CELL.2017.11.014
Page generated: Sat Dec 12 05:58:35 2020

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