Calcium in PDB 6bgi: Cryo-Em Structure of the TMEM16A Calcium-Activated Chloride Channel in Nanodisc

Calcium Binding Sites:

The binding sites of Calcium atom in the Cryo-Em Structure of the TMEM16A Calcium-Activated Chloride Channel in Nanodisc (pdb code 6bgi). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Cryo-Em Structure of the TMEM16A Calcium-Activated Chloride Channel in Nanodisc, PDB code: 6bgi:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in 6bgi

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Calcium binding site 1 out of 4 in the Cryo-Em Structure of the TMEM16A Calcium-Activated Chloride Channel in Nanodisc


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of the TMEM16A Calcium-Activated Chloride Channel in Nanodisc within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1001

b:0.4
occ:1.00
OE1 A:GLU650 2.0 0.6 1.0
OE1 A:GLU701 2.3 65.8 1.0
OE1 A:GLU730 2.6 68.0 1.0
CD A:GLU650 2.7 0.6 1.0
OD1 A:ASP734 2.7 79.5 1.0
OE2 A:GLU650 2.8 0.6 1.0
OD2 A:ASP734 3.0 79.5 1.0
CG A:ASP734 3.2 79.5 1.0
CD A:GLU701 3.3 65.8 1.0
OE2 A:GLU701 3.5 65.8 1.0
CD A:GLU730 3.7 68.0 1.0
CG A:GLU650 4.1 0.6 1.0
OE2 A:GLU730 4.2 68.0 1.0
CB A:GLU650 4.6 0.6 1.0
CD2 A:LEU733 4.7 74.7 1.0
CG A:GLU701 4.7 65.8 1.0
CB A:ASP734 4.7 79.5 1.0
OD1 A:ASN647 4.8 88.8 1.0
O A:GLU730 4.8 68.0 1.0

Calcium binding site 2 out of 4 in 6bgi

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Calcium binding site 2 out of 4 in the Cryo-Em Structure of the TMEM16A Calcium-Activated Chloride Channel in Nanodisc


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryo-Em Structure of the TMEM16A Calcium-Activated Chloride Channel in Nanodisc within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1002

b:0.8
occ:1.00
O A:LEU643 2.1 79.0 1.0
OE2 A:GLU701 2.3 65.8 1.0
OE2 A:GLU730 2.7 68.0 1.0
C A:LEU643 3.0 79.0 1.0
OD1 A:ASN646 3.2 91.2 1.0
CA A:LEU643 3.2 79.0 1.0
ND2 A:ASN726 3.3 71.3 1.0
CB A:LEU643 3.3 79.0 1.0
CD A:GLU701 3.3 65.8 1.0
CD A:GLU730 3.8 68.0 1.0
CG A:GLU701 3.8 65.8 1.0
CD2 A:LEU643 3.8 79.0 1.0
CG A:ASN646 4.1 91.2 1.0
CG A:LEU643 4.2 79.0 1.0
CB A:ASN647 4.2 88.8 1.0
CG A:ASN726 4.2 71.3 1.0
N A:ILE644 4.3 83.0 1.0
OD1 A:ASN726 4.3 71.3 1.0
CA A:ASN647 4.4 88.8 1.0
OE1 A:GLU730 4.4 68.0 1.0
ND2 A:ASN646 4.4 91.2 1.0
OE1 A:GLU701 4.4 65.8 1.0
N A:ASN647 4.4 88.8 1.0
CG A:ASN647 4.6 88.8 1.0
OE2 A:GLU650 4.6 0.6 1.0
N A:LEU643 4.7 79.0 1.0
CG A:GLU730 4.8 68.0 1.0
OD1 A:ASN647 4.9 88.8 1.0
CA A:ILE644 4.9 83.0 1.0

Calcium binding site 3 out of 4 in 6bgi

Go back to Calcium Binding Sites List in 6bgi
Calcium binding site 3 out of 4 in the Cryo-Em Structure of the TMEM16A Calcium-Activated Chloride Channel in Nanodisc


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Cryo-Em Structure of the TMEM16A Calcium-Activated Chloride Channel in Nanodisc within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca1001

b:0.4
occ:1.00
OE1 B:GLU701 2.4 65.8 1.0
OE1 B:GLU650 2.5 0.6 1.0
OE2 B:GLU650 2.6 0.6 1.0
CD B:GLU650 2.7 0.6 1.0
OD1 B:ASP734 2.9 79.5 1.0
CD B:GLU701 3.5 65.8 1.0
OD2 B:ASP734 3.5 79.5 1.0
CG B:ASP734 3.6 79.5 1.0
OE1 B:GLU730 3.8 68.0 1.0
CG B:GLU650 4.0 0.6 1.0
OE2 B:GLU701 4.1 65.8 1.0
CB B:GLU650 4.6 0.6 1.0
CB B:GLU701 4.6 65.8 1.0
CG B:GLU701 4.7 65.8 1.0
NZ B:LYS737 4.8 81.8 1.0
CD B:GLU730 4.9 68.0 1.0

Calcium binding site 4 out of 4 in 6bgi

Go back to Calcium Binding Sites List in 6bgi
Calcium binding site 4 out of 4 in the Cryo-Em Structure of the TMEM16A Calcium-Activated Chloride Channel in Nanodisc


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Cryo-Em Structure of the TMEM16A Calcium-Activated Chloride Channel in Nanodisc within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca1002

b:0.8
occ:1.00
OE2 B:GLU701 2.3 65.8 1.0
O B:LEU643 2.4 79.0 1.0
OD1 B:ASN646 3.0 91.2 1.0
OE2 B:GLU730 3.1 68.0 1.0
C B:LEU643 3.1 79.0 1.0
CA B:LEU643 3.2 79.0 1.0
CD B:GLU701 3.3 65.8 1.0
CB B:LEU643 3.3 79.0 1.0
CD2 B:LEU643 3.6 79.0 1.0
CG B:GLU701 3.6 65.8 1.0
ND2 B:ASN726 3.6 71.3 1.0
CG B:ASN646 3.9 91.2 1.0
ND2 B:ASN646 4.0 91.2 1.0
CG B:LEU643 4.1 79.0 1.0
CD B:GLU730 4.1 68.0 1.0
OE1 B:GLU701 4.4 65.8 1.0
N B:ILE644 4.4 83.0 1.0
CB B:ASN647 4.5 88.8 1.0
N B:ASN647 4.5 88.8 1.0
CA B:ASN647 4.5 88.8 1.0
OE2 B:GLU650 4.5 0.6 1.0
OE1 B:GLU730 4.6 68.0 1.0
CG B:ASN726 4.6 71.3 1.0
N B:LEU643 4.6 79.0 1.0
OD1 B:ASN726 4.7 71.3 1.0
CG B:ASN647 4.9 88.8 1.0
O B:GLN642 5.0 79.7 1.0
CD1 B:LEU643 5.0 79.0 1.0

Reference:

S.Dang, S.Feng, J.Tien, C.J.Peters, D.Bulkley, M.Lolicato, J.Zhao, K.Zuberbuhler, W.Ye, L.Qi, T.Chen, C.S.Craik, Y.Nung Jan, D.L.Minor, Y.Cheng, L.Yeh Jan. Cryo-Em Structures of the TMEM16A Calcium-Activated Chloride Channel. Nature V. 552 426 2017.
ISSN: ESSN 1476-4687
PubMed: 29236684
DOI: 10.1038/NATURE25024
Page generated: Sat Dec 12 05:58:47 2020

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