Calcium in PDB 6gdk: Calcium Bound Form of Human Calmodulin Mutant F141L

The binding sites of Calcium atom in the Calcium Bound Form of Human Calmodulin Mutant F141L (pdb code 6gdk). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Calcium Bound Form of Human Calmodulin Mutant F141L, PDB code: 6gdk:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Calcium Bound Form of Human Calmodulin Mutant F141L


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Calcium Bound Form of Human Calmodulin Mutant F141L within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca201 b:25.0 occ:1.00 OD1 A:ASP20 2.4 50.0 1.0 OD1 A:ASP24 2.5 50.0 1.0 OE2 A:GLU31 2.5 75.0 1.0 O A:THR26 2.5 25.0 1.0 OE1 A:GLU31 2.6 75.0 1.0 OD1 A:ASP22 2.6 50.0 1.0 CD A:GLU31 2.8 25.0 1.0 OD2 A:ASP22 2.8 50.0 1.0 OD2 A:ASP24 2.9 50.0 1.0 CG A:ASP24 2.9 25.0 1.0 CG A:ASP22 3.1 25.0 1.0 CG A:ASP20 3.1 25.0 1.0 HA A:ILE27 3.2 25.0 1.0 HG21 A:THR28 3.2 25.0 1.0 H A:THR28 3.5 25.0 1.0 HA A:ASP20 3.6 25.0 1.0 OD2 A:ASP20 3.7 50.0 1.0 C A:THR26 3.7 25.0 1.0 H A:ASP24 3.7 25.0 1.0 H A:THR26 3.9 25.0 1.0 H A:ASP22 3.9 25.0 1.0 CB A:ASP20 4.0 25.0 1.0 HB2 A:ASP20 4.0 50.0 1.0 CA A:ILE27 4.1 25.0 1.0 N A:THR28 4.2 25.0 1.0 CG2 A:THR28 4.2 25.0 1.0 CG A:GLU31 4.2 25.0 1.0 CB A:ASP24 4.3 25.0 1.0 CA A:ASP20 4.3 25.0 1.0 HB2 A:GLU31 4.3 50.0 1.0 H A:GLY23 4.3 25.0 1.0 N A:ILE27 4.4 25.0 1.0 HB3 A:ASP24 4.5 50.0 1.0 HG22 A:THR28 4.5 25.0 1.0 N A:ASP24 4.6 25.0 1.0 CB A:ASP22 4.6 25.0 1.0 H A:GLY25 4.6 25.0 1.0 C A:ILE27 4.6 25.0 1.0 HB3 A:GLU31 4.6 50.0 1.0 N A:THR26 4.7 25.0 1.0 CB A:GLU31 4.7 25.0 1.0 HG23 A:THR28 4.7 25.0 1.0 H A:LYS21 4.8 25.0 1.0 CA A:THR26 4.8 25.0 1.0 HG2 A:GLU31 4.8 25.0 1.0 OG1 A:THR26 4.8 25.0 1.0 HG1 A:THR26 4.8 25.0 1.0 N A:ASP22 4.8 25.0 1.0 HG3 A:GLU31 4.9 25.0 1.0 C A:ASP20 4.9 25.0 1.0 HG21 A:ILE27 4.9 25.0 1.0 CA A:ASP24 5.0 25.0 1.0 N A:GLY23 5.0 25.0 1.0

Calcium binding site 2 out of 4 in the Calcium Bound Form of Human Calmodulin Mutant F141L


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Calcium Bound Form of Human Calmodulin Mutant F141L within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca202 b:25.0 occ:1.00 OD1 A:ASP56 2.4 50.0 1.0 OE2 A:GLU67 2.5 50.0 1.0 OD1 A:ASP58 2.6 50.0 1.0 O A:THR62 2.6 25.0 1.0 OD1 A:ASN60 2.7 25.0 1.0 HB2 A:ASP58 2.7 50.0 1.0 OE1 A:GLU67 2.8 50.0 1.0 OD1 A:ASP64 2.9 25.0 1.0 CD A:GLU67 3.0 25.0 1.0 CG A:ASP56 3.0 25.0 1.0 HB2 A:ASN60 3.1 25.0 1.0 OD2 A:ASP64 3.2 25.0 1.0 OD2 A:ASP56 3.3 50.0 1.0 CG A:ASP64 3.4 25.0 1.0 CG A:ASP58 3.4 25.0 1.0 CB A:ASP58 3.5 25.0 1.0 H A:ASN60 3.5 25.0 1.0 CG A:ASN60 3.6 25.0 1.0 H A:ASP64 3.7 25.0 1.0 H A:THR62 3.8 25.0 1.0 OG1 A:THR62 3.8 25.0 1.0 CB A:ASN60 3.8 25.0 1.0 C A:THR62 3.8 25.0 1.0 H A:ASP58 3.9 25.0 1.0 HB3 A:ASP58 4.1 50.0 1.0 HA A:ASP56 4.2 25.0 1.0 HA A:ILE63 4.2 25.0 1.0 CB A:ASP56 4.3 25.0 1.0 N A:ASN60 4.4 25.0 1.0 CG A:GLU67 4.4 25.0 1.0 HB2 A:ASP56 4.5 50.0 1.0 HG1 A:THR62 4.5 25.0 1.0 N A:ASP64 4.5 25.0 1.0 H A:GLY59 4.5 25.0 1.0 N A:THR62 4.5 25.0 1.0 HB3 A:ASN60 4.6 25.0 1.0 CA A:THR62 4.6 25.0 1.0 OD2 A:ASP58 4.6 50.0 1.0 CA A:ASP58 4.6 25.0 1.0 N A:ASP58 4.6 25.0 1.0 HG3 A:GLU67 4.7 25.0 1.0 CA A:ASN60 4.7 25.0 1.0 H A:GLY61 4.7 25.0 1.0 CA A:ASP56 4.7 25.0 1.0 CB A:ASP64 4.7 25.0 1.0 ND2 A:ASN60 4.7 25.0 1.0 CB A:THR62 4.7 25.0 1.0 N A:ILE63 4.8 25.0 1.0 CA A:ILE63 4.9 25.0 1.0 N A:GLY59 4.9 25.0 1.0 HG2 A:GLU67 5.0 25.0 1.0

Calcium binding site 3 out of 4 in the Calcium Bound Form of Human Calmodulin Mutant F141L


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Calcium Bound Form of Human Calmodulin Mutant F141L within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca203 b:25.0 occ:1.00 OD1 A:ASP93 2.3 50.0 1.0 O A:TYR99 2.4 25.0 1.0 OE1 A:GLU104 2.4 50.0 1.0 OD1 A:ASN97 2.4 25.0 1.0 OD2 A:ASP93 2.4 50.0 1.0 CG A:ASP93 2.6 25.0 1.0 HD21 A:ASN97 2.7 50.0 1.0 OD1 A:ASP95 2.7 50.0 1.0 CG A:ASN97 2.8 25.0 1.0 ND2 A:ASN97 2.9 25.0 1.0 HA A:ILE100 3.3 25.0 1.0 OG A:SER101 3.4 25.0 1.0 H A:ASN97 3.4 25.0 1.0 CG A:ASP95 3.5 25.0 1.0 CD A:GLU104 3.5 25.0 1.0 HB2 A:GLU104 3.5 50.0 1.0 C A:TYR99 3.5 25.0 1.0 OD2 A:ASP95 3.6 50.0 1.0 HD22 A:ASN97 3.6 50.0 1.0 H A:TYR99 3.7 25.0 1.0 HG2 A:GLU104 3.7 25.0 1.0 H A:SER101 3.7 25.0 1.0 HA A:ASP93 3.8 25.0 1.0 CB A:ASN97 4.0 25.0 1.0 HG A:SER101 4.0 25.0 1.0 CG A:GLU104 4.0 25.0 1.0 CB A:ASP93 4.0 25.0 1.0 CA A:ILE100 4.1 25.0 1.0 HB3 A:ASN97 4.1 50.0 1.0 N A:SER101 4.1 25.0 1.0 HB2 A:SER101 4.2 50.0 1.0 CB A:GLU104 4.2 25.0 1.0 N A:ASN97 4.2 25.0 1.0 N A:ILE100 4.3 25.0 1.0 CB A:SER101 4.4 25.0 1.0 C A:ILE100 4.4 25.0 1.0 HB3 A:GLU104 4.4 50.0 1.0 CA A:ASP93 4.4 25.0 1.0 N A:TYR99 4.4 25.0 1.0 H A:ASP95 4.5 25.0 1.0 CA A:ASN97 4.5 25.0 1.0 HB3 A:ASP93 4.6 50.0 1.0 H A:GLY98 4.6 25.0 1.0 OE2 A:GLU104 4.6 50.0 1.0 H A:GLY96 4.6 25.0 1.0 HB2 A:ASP93 4.6 50.0 1.0 CA A:TYR99 4.7 25.0 1.0 HB2 A:TYR99 4.8 50.0 1.0 HB2 A:ASN97 4.8 50.0 1.0 CB A:ASP95 4.8 25.0 1.0 C A:ASN97 4.8 25.0 1.0 N A:GLY98 4.9 25.0 1.0 C A:ASP93 4.9 25.0 1.0 HG13 A:ILE100 4.9 25.0 1.0 CA A:SER101 4.9 25.0 1.0 N A:GLY96 5.0 25.0 1.0

Calcium binding site 4 out of 4 in the Calcium Bound Form of Human Calmodulin Mutant F141L


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Calcium Bound Form of Human Calmodulin Mutant F141L within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca204 b:25.0 occ:1.00 OD1 A:ASP133 2.3 50.0 1.0 OD1 A:ASP129 2.5 50.0 1.0 O A:GLN135 2.5 25.0 1.0 CD A:GLU140 2.6 25.0 1.0 OE1 A:GLU140 2.7 50.0 1.0 OD1 A:ASP131 2.7 50.0 1.0 OE2 A:GLU140 2.7 50.0 1.0 OD2 A:ASP133 2.8 50.0 1.0 CG A:ASP133 2.8 25.0 1.0 HA A:ASP129 3.0 25.0 1.0 HG2 A:GLU140 3.2 25.0 1.0 CG A:GLU140 3.5 25.0 1.0 CG A:ASP129 3.6 25.0 1.0 H A:GLN135 3.6 25.0 1.0 H A:ASP133 3.6 25.0 1.0 CG A:ASP131 3.7 25.0 1.0 C A:GLN135 3.8 25.0 1.0 HA A:VAL136 3.9 25.0 1.0 HG2 A:GLN135 3.9 25.0 1.0 CA A:ASP129 4.0 25.0 1.0 OD2 A:ASP131 4.1 50.0 1.0 H A:ASP131 4.2 25.0 1.0 CB A:ASP133 4.2 25.0 1.0 HG3 A:GLU140 4.3 25.0 1.0 H A:GLY134 4.3 25.0 1.0 HB3 A:GLU140 4.3 50.0 1.0 CB A:ASP129 4.3 25.0 1.0 OD2 A:ASP129 4.4 50.0 1.0 N A:GLN135 4.4 25.0 1.0 N A:ASP133 4.4 25.0 1.0 CB A:GLU140 4.4 25.0 1.0 O A:ALA128 4.4 25.0 1.0 H A:ASN137 4.5 25.0 1.0 HB3 A:ASP133 4.5 25.0 1.0 H A:GLY132 4.6 25.0 1.0 HB2 A:GLU140 4.6 50.0 1.0 HG22 A:VAL136 4.6 50.0 1.0 CA A:GLN135 4.7 25.0 1.0 N A:VAL136 4.7 25.0 1.0 C A:ASP129 4.7 25.0 1.0 HB2 A:ASP129 4.7 50.0 1.0 CA A:VAL136 4.7 25.0 1.0 CA A:ASP133 4.8 25.0 1.0 N A:GLY134 4.8 25.0 1.0 H A:ILE130 4.8 25.0 1.0 N A:ASP129 4.9 25.0 1.0 CG A:GLN135 4.9 25.0 1.0 HB2 A:ASP133 5.0 25.0 1.0 N A:ASP131 5.0 25.0 1.0 N A:GLY132 5.0 25.0 1.0 CB A:ASP131 5.0 25.0 1.0

K.Wang, C.Holt, J.Lu, M.Brohus, K.T.Larsen, M.T.Overgaard, R.Wimmer, F.Van Petegem. Arrhythmia Mutations in Calmodulin Cause Conformational Changes That Affect Interactions with the Cardiac Voltage-Gated Calcium Channel. Proc. Natl. Acad. Sci. V. 115 10556 2018U.S.A..
ISSN: ESSN 1091-6490
PubMed: 30348784
DOI: 10.1073/PNAS.1808733115