Calcium in PDB 6gfe: High-Resolution Structure of A Therapeutic Full-Length Anti-Npra Antibody with Exceptional Conformational Diversity

The structure of High-Resolution Structure of A Therapeutic Full-Length Anti-Npra Antibody with Exceptional Conformational Diversity, PDB code: 6gfe was solved by S.Hoerer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.00 / 1.80
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	65.780, 160.510, 87.300, 90.00, 110.72, 90.00
R / Rfree (%)	18.1 / 20

The binding sites of Calcium atom in the High-Resolution Structure of A Therapeutic Full-Length Anti-Npra Antibody with Exceptional Conformational Diversity (pdb code 6gfe). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the High-Resolution Structure of A Therapeutic Full-Length Anti-Npra Antibody with Exceptional Conformational Diversity, PDB code: 6gfe:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the High-Resolution Structure of A Therapeutic Full-Length Anti-Npra Antibody with Exceptional Conformational Diversity


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of High-Resolution Structure of A Therapeutic Full-Length Anti-Npra Antibody with Exceptional Conformational Diversity within 5.0Å range: probe atom residue distance (Å) B Occ H:Ca508 b:75.6 occ:1.00 O H:HOH607 2.1 30.4 1.0 OG H:SER33 2.3 48.3 1.0 O H:HOH867 2.4 49.8 1.0 OD1 H:ASP96 2.5 36.4 1.0 O H:HOH916 2.6 48.9 1.0 OD2 H:ASP96 3.0 40.2 1.0 CG H:ASP96 3.1 36.3 1.0 CB H:SER33 3.5 36.9 1.0 OG H:SER31 4.0 35.1 1.0 OD2 H:ASP27 4.4 40.1 1.0 C H:SER33 4.4 35.5 1.0 CA H:SER33 4.5 32.1 1.0 NH1 H:ARG94 4.5 26.8 1.0 CB H:ASP96 4.6 27.6 1.0 N H:ALA34 4.6 29.1 1.0 O H:SER33 4.8 37.9 1.0 CB H:ALA34 4.8 28.1 1.0 CZ H:ARG94 5.0 43.0 1.0

Calcium binding site 2 out of 2 in the High-Resolution Structure of A Therapeutic Full-Length Anti-Npra Antibody with Exceptional Conformational Diversity


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of High-Resolution Structure of A Therapeutic Full-Length Anti-Npra Antibody with Exceptional Conformational Diversity within 5.0Å range: probe atom residue distance (Å) B Occ K:Ca508 b:34.0 occ:1.00 O K:HOH715 2.3 28.5 1.0 O K:HOH1063 2.4 29.7 1.0 O K:HOH701 2.5 31.6 1.0 O K:GLU430 2.5 25.6 1.0 O K:HOH704 2.6 37.4 1.0 C K:GLU430 3.5 25.9 1.0 CA K:ALA431 4.2 22.2 1.0 N K:ALA431 4.3 22.1 1.0 NE2 K:HIS435 4.3 26.5 1.0 OE2 K:GLU430 4.5 35.9 1.0 CA K:GLU430 4.5 22.5 1.0 CD2 K:HIS435 4.6 26.5 1.0 CB K:GLU430 4.7 24.1 1.0 C K:ALA431 4.8 26.6 1.0 O K:LEU432 5.0 25.7 1.0

M.Blech, S.Horer, A.B.Kuhn, S.Kube, H.Goddeke, H.Kiefer, Y.Zang, Y.Alber, S.M.Kast, M.Westermann, M.D.Tully, L.V.Schafer, P.Garidel. Structure of A Therapeutic Full-Length Anti-Npra IGG4 Antibody: Dissecting Conformational Diversity. Biophys.J. V. 116 1637 2019.
ISSN: ESSN 1542-0086
PubMed: 31023536
DOI: 10.1016/J.BPJ.2019.03.036