Atomistry » Calcium » PDB 6guy-6hhy » 6h7y
Atomistry »
  Calcium »
    PDB 6guy-6hhy »
      6h7y »

Calcium in PDB 6h7y: X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 1-79-1

Enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 1-79-1

All present enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 1-79-1:
3.4.17.21;

Protein crystallography data

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 1-79-1, PDB code: 6h7y was solved by L.Motlova, Z.Novakova, C.Barinka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.26 / 1.81
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 102.258, 131.376, 159.874, 90.00, 90.00, 90.00
R / Rfree (%) 15 / 17.8

Other elements in 6h7y:

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 1-79-1 also contains other interesting chemical elements:

Fluorine (F) 1 atom
Zinc (Zn) 2 atoms
Chlorine (Cl) 2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 1-79-1 (pdb code 6h7y). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 1-79-1, PDB code: 6h7y:

Calcium binding site 1 out of 1 in 6h7y

Go back to Calcium Binding Sites List in 6h7y
Calcium binding site 1 out of 1 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 1-79-1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 1-79-1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca819

b:31.6
occ:1.00
 O A:TYR272 2.3 32.0 1.0
OE2 A:GLU436 2.4 32.2 1.0
O A:HOH925 2.4 30.9 1.0
OE1 A:GLU433 2.5 31.6 1.0
O A:THR269 2.5 31.7 1.0
OE2 A:GLU433 2.5 30.6 1.0
OG1 A:THR269 2.5 32.3 1.0
CD A:GLU433 2.8 30.8 1.0
CB A:THR269 3.3 32.8 1.0
C A:THR269 3.4 34.5 1.0
C A:TYR272 3.4 31.1 1.0
CD A:GLU436 3.5 32.7 1.0
OE1 A:GLU436 3.9 30.2 1.0
CA A:THR269 4.0 32.0 1.0
N A:TYR272 4.0 32.4 1.0
CA A:PRO273 4.2 33.1 1.0
CB A:ASP266 4.2 30.9 1.0
N A:ALA274 4.2 32.7 1.0
N A:PRO273 4.3 32.7 1.0
CG A:GLU433 4.3 31.4 1.0
N A:PRO270 4.3 30.8 1.0
CA A:TYR272 4.4 32.4 1.0
C A:PRO273 4.4 33.7 1.0
CA A:PRO270 4.5 31.5 1.0
N A:ASP266 4.5 30.9 1.0
N A:GLY271 4.5 33.1 1.0
O A:ALA264 4.6 30.2 1.0
O A:ASP266 4.6 33.3 1.0
CG2 A:THR269 4.7 34.6 1.0
N A:THR269 4.7 32.7 1.0
CG A:GLU436 4.7 31.9 1.0
OD2 A:ASP266 4.8 32.6 1.0
C A:PRO270 4.8 33.9 1.0
CB A:ALA274 4.9 35.6 1.0
CA A:ASP266 4.9 30.3 1.0
CB A:GLU436 5.0 32.2 1.0

Reference:

R.Nakajima, Z.Novakova, W.Tueckmantel, L.Motlova, C.Barinka, A.P.Kozikowski. 2-Aminoadipic Acid-C(O)-Glutamate Based Prostate-Specific Membrane Antigen Ligands For Potential Use As Theranostics. Acs Med Chem Lett V. 9 1099 2018.
ISSN: ISSN 1948-5875
PubMed: 30429952
DOI: 10.1021/ACSMEDCHEMLETT.8B00318
Page generated: Tue Jul 16 08:18:11 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy