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Calcium in PDB 6h7z: X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-65-1

Enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-65-1

All present enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-65-1:
3.4.17.21;

Protein crystallography data

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-65-1, PDB code: 6h7z was solved by L.Motlova, Z.Novakova, C.Barinka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.00
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 101.222, 130.389, 158.469, 90.00, 90.00, 90.00
R / Rfree (%) 17 / 20.6

Other elements in 6h7z:

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-65-1 also contains other interesting chemical elements:

Fluorine (F) 1 atom
Zinc (Zn) 2 atoms
Chlorine (Cl) 1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-65-1 (pdb code 6h7z). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-65-1, PDB code: 6h7z:

Calcium binding site 1 out of 1 in 6h7z

Go back to Calcium Binding Sites List in 6h7z
Calcium binding site 1 out of 1 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-65-1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-65-1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca803

b:11.8
occ:1.00
 O A:TYR272 2.3 12.3 1.0
OE2 A:GLU436 2.4 13.1 1.0
OG1 A:THR269 2.4 12.7 1.0
O A:HOH994 2.4 11.6 1.0
O A:THR269 2.4 12.8 1.0
OE2 A:GLU433 2.4 11.7 1.0
OE1 A:GLU433 2.4 11.4 1.0
CD A:GLU433 2.8 11.1 1.0
CB A:THR269 3.3 12.9 1.0
C A:THR269 3.3 12.8 1.0
CD A:GLU436 3.5 12.4 1.0
C A:TYR272 3.5 12.3 1.0
OE1 A:GLU436 3.9 12.3 1.0
CA A:THR269 3.9 12.9 1.0
N A:TYR272 4.0 12.0 1.0
CB A:ASP266 4.2 13.1 1.0
N A:PRO270 4.2 12.7 1.0
N A:ALA274 4.3 12.9 1.0
CG A:GLU433 4.3 11.1 1.0
CA A:PRO273 4.3 12.8 1.0
N A:PRO273 4.4 12.7 1.0
CA A:TYR272 4.4 12.0 1.0
N A:GLY271 4.5 11.9 1.0
CA A:PRO270 4.5 12.2 1.0
N A:ASP266 4.5 12.1 1.0
C A:PRO273 4.5 12.9 1.0
O A:ALA264 4.6 10.2 1.0
O A:ASP266 4.6 13.1 1.0
CG2 A:THR269 4.6 13.1 1.0
N A:THR269 4.6 13.0 1.0
OD2 A:ASP266 4.7 13.6 1.0
CG A:GLU436 4.7 12.2 1.0
C A:PRO270 4.8 12.1 1.0
CA A:ASP266 4.8 12.5 1.0
CB A:ALA274 4.9 13.7 1.0
CG A:ASP266 4.9 13.3 1.0
CB A:GLU436 5.0 12.3 1.0
C A:GLY271 5.0 11.9 1.0

Reference:

R.Nakajima, Z.Novakova, W.Tueckmantel, L.Motlova, C.Barinka, A.P.Kozikowski. 2-Aminoadipic Acid-C(O)-Glutamate Based Prostate-Specific Membrane Antigen Ligands For Potential Use As Theranostics. Acs Med Chem Lett V. 9 1099 2018.
ISSN: ISSN 1948-5875
PubMed: 30429952
DOI: 10.1021/ACSMEDCHEMLETT.8B00318
Page generated: Tue Jul 16 08:18:37 2024

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