Calcium in PDB 6hkz: X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-49-1

Enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-49-1

All present enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-49-1:
3.4.17.21;

Protein crystallography data

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-49-1, PDB code: 6hkz was solved by L.Motlova, Z.Novakova, C.Barinka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.59 / 2.09
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 102.956, 132.259, 161.589, 90.00, 90.00, 90.00
R / Rfree (%) 17 / 20.3

Other elements in 6hkz:

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-49-1 also contains other interesting chemical elements:

Fluorine (F) 1 atom
Zinc (Zn) 2 atoms
Chlorine (Cl) 1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-49-1 (pdb code 6hkz). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-49-1, PDB code: 6hkz:

Calcium binding site 1 out of 1 in 6hkz

Go back to Calcium Binding Sites List in 6hkz
Calcium binding site 1 out of 1 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-49-1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Inhibitor Rna 2-49-1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca803

b:44.6
occ:1.00
O A:THR269 2.4 47.6 1.0
O A:TYR272 2.4 44.8 1.0
OE2 A:GLU436 2.4 48.0 1.0
O A:HOH1004 2.4 42.8 1.0
OE2 A:GLU433 2.5 44.1 1.0
OE1 A:GLU433 2.5 42.9 1.0
OG1 A:THR269 2.5 41.8 1.0
CD A:GLU433 2.8 45.9 1.0
C A:THR269 3.3 48.2 1.0
CB A:THR269 3.4 47.6 1.0
C A:TYR272 3.5 44.5 1.0
CD A:GLU436 3.5 45.9 1.0
CA A:THR269 4.0 47.1 1.0
N A:TYR272 4.0 45.4 1.0
OE1 A:GLU436 4.1 42.9 1.0
CB A:ASP266 4.2 49.4 1.0
CA A:PRO273 4.2 44.0 1.0
N A:ALA274 4.3 46.6 1.0
CG A:GLU433 4.3 45.7 1.0
N A:PRO270 4.3 48.4 1.0
N A:PRO273 4.4 42.6 1.0
CA A:TYR272 4.4 44.5 1.0
C A:PRO273 4.4 46.8 1.0
N A:ASP266 4.6 47.6 1.0
N A:GLY271 4.6 46.2 1.0
CA A:PRO270 4.6 45.5 1.0
O A:ALA264 4.7 45.8 1.0
O A:ASP266 4.7 44.3 1.0
CG2 A:THR269 4.7 47.5 1.0
N A:THR269 4.7 47.3 1.0
OD2 A:ASP266 4.7 47.2 1.0
CG A:GLU436 4.7 45.1 1.0
C A:PRO270 4.8 49.4 1.0
CB A:ALA274 4.9 46.5 1.0
CA A:ASP266 4.9 45.5 1.0
C A:GLY271 5.0 46.2 1.0

Reference:

R.Nakajima, Z.Novakova, W.Tueckmantel, L.Motlova, C.Barinka, A.P.Kozikowski. 2-Aminoadipic Acid-C(O)-Glutamate Based Prostate-Specific Membrane Antigen Ligands For Potential Use As Theranostics. Acs Med Chem Lett V. 9 1099 2018.
ISSN: ISSN 1948-5875
PubMed: 30429952
DOI: 10.1021/ACSMEDCHEMLETT.8B00318
Page generated: Sat Dec 12 06:09:53 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy