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Calcium in PDB 6hza: X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Glutaryl-Arg-Arg-Lys]-Arg-4-Amba
Enzymatic activity of X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Glutaryl-Arg-Arg-Lys]-Arg-4-Amba
All present enzymatic activity of X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Glutaryl-Arg-Arg-Lys]-Arg-4-Amba:
3.4.21.75;
3.4.21.75;
Protein crystallography data
The structure of X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Glutaryl-Arg-Arg-Lys]-Arg-4-Amba, PDB code: 6hza
was solved by
S.O.Dahms,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 45.88 / 1.90 |
| Space group | P 65 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 131.371, 131.371, 155.195, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 16.6 / 18.6 |
Other elements in 6hza:
The structure of X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Glutaryl-Arg-Arg-Lys]-Arg-4-Amba also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
| Sodium | (Na) | 3 atoms |
Calcium Binding Sites:
The binding sites of Calcium atom in the X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Glutaryl-Arg-Arg-Lys]-Arg-4-Amba
(pdb code 6hza). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Glutaryl-Arg-Arg-Lys]-Arg-4-Amba, PDB code: 6hza:
Jump to Calcium binding site number: 1; 2; 3;
In total 3 binding sites of Calcium where determined in the X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Glutaryl-Arg-Arg-Lys]-Arg-4-Amba, PDB code: 6hza:
Jump to Calcium binding site number: 1; 2; 3;
Calcium binding site 1 out of 3 in 6hza
Go back to
Calcium Binding Sites List in 6hza
Calcium binding site 1 out
of 3 in the X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Glutaryl-Arg-Arg-Lys]-Arg-4-Amba
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Glutaryl-Arg-Arg-Lys]-Arg-4-Amba within 5.0Å range:
|
Calcium binding site 2 out of 3 in 6hza
Go back to
Calcium Binding Sites List in 6hza
Calcium binding site 2 out
of 3 in the X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Glutaryl-Arg-Arg-Lys]-Arg-4-Amba
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 2 of X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Glutaryl-Arg-Arg-Lys]-Arg-4-Amba within 5.0Å range:
|
Calcium binding site 3 out of 3 in 6hza
Go back to
Calcium Binding Sites List in 6hza
Calcium binding site 3 out
of 3 in the X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Glutaryl-Arg-Arg-Lys]-Arg-4-Amba
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 3 of X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Glutaryl-Arg-Arg-Lys]-Arg-4-Amba within 5.0Å range:
|
Reference:
T.Van Lam Van,
T.Ivanova,
K.Hardes,
M.R.Heindl,
R.E.Morty,
E.Bottcher-Friebertshauser,
I.Lindberg,
M.E.Than,
S.O.Dahms,
T.Steinmetzer.
Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem V. 14 673 2019.
ISSN: ESSN 1860-7187
PubMed: 30680958
DOI: 10.1002/CMDC.201800807
Page generated: Tue Jul 16 08:35:46 2024
ISSN: ESSN 1860-7187
PubMed: 30680958
DOI: 10.1002/CMDC.201800807
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