Calcium in PDB 6mx0: Crystal Structure of Human Sting Apoprotein (G230A, H232R, R293Q)

Protein crystallography data

The structure of Crystal Structure of Human Sting Apoprotein (G230A, H232R, R293Q), PDB code: 6mx0 was solved by C.A.Lesburg, T.Siu, T.Ho, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.16 / 1.73
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 70.470, 77.460, 126.580, 90.00, 90.00, 90.00
R / Rfree (%) 20.8 / 22

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of Human Sting Apoprotein (G230A, H232R, R293Q) (pdb code 6mx0). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Crystal Structure of Human Sting Apoprotein (G230A, H232R, R293Q), PDB code: 6mx0:

Calcium binding site 1 out of 1 in 6mx0

Go back to Calcium Binding Sites List in 6mx0
Calcium binding site 1 out of 1 in the Crystal Structure of Human Sting Apoprotein (G230A, H232R, R293Q)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Human Sting Apoprotein (G230A, H232R, R293Q) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca401

b:25.1
occ:1.00
O B:HOH556 2.2 28.4 1.0
OD1 B:ASP320 2.3 37.1 1.0
O B:ALA318 2.4 26.8 1.0
CG B:ASP320 3.5 45.5 1.0
C B:ALA318 3.5 27.3 1.0
OD2 B:ASP320 4.1 63.6 1.0
CA B:ALA318 4.1 24.0 1.0
N B:ASP320 4.2 32.2 1.0
N B:ASP319 4.6 23.4 1.0
O B:PRO317 4.6 24.6 1.0
CB B:ASP320 4.6 36.2 1.0
O B:HOH574 4.6 34.4 1.0
O B:HOH589 4.7 59.2 0.5
CA B:ASP320 4.7 34.2 1.0
CA B:ASP319 4.8 23.6 1.0
C B:ASP319 4.9 29.7 1.0
CB B:ALA318 5.0 24.6 1.0

Reference:

T.Siu, M.D.Altman, G.A.Baltus, M.Childers, J.M.Ellis, H.Gunaydin, H.Hatch, T.Ho, J.Jewell, B.M.Lacey, C.A.Lesburg, B.S.Pan, B.Sauvagnat, G.K.Schroeder, S.Xu. Discovery of A Novel Cgamp Competitive Ligand of the Inactive Form of Sting. Acs Med Chem Lett V. 10 92 2019.
ISSN: ISSN 1948-5875
PubMed: 30655953
DOI: 10.1021/ACSMEDCHEMLETT.8B00466
Page generated: Sat Dec 12 07:15:27 2020

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