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Atomistry » Calcium » PDB 6p8w-6ptk » 6pgp » |
Calcium in PDB 6pgp: Crystal Structure of Human Kras G12C Covalently Bound to A Quinazolinone InhibitorProtein crystallography data
The structure of Crystal Structure of Human Kras G12C Covalently Bound to A Quinazolinone Inhibitor, PDB code: 6pgp
was solved by
C.Mohr,
D.A.Whittington,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6pgp:
The structure of Crystal Structure of Human Kras G12C Covalently Bound to A Quinazolinone Inhibitor also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the Crystal Structure of Human Kras G12C Covalently Bound to A Quinazolinone Inhibitor
(pdb code 6pgp). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Crystal Structure of Human Kras G12C Covalently Bound to A Quinazolinone Inhibitor, PDB code: 6pgp: Jump to Calcium binding site number: 1; 2; 3; 4; Calcium binding site 1 out of 4 in 6pgpGo back to Calcium Binding Sites List in 6pgp
Calcium binding site 1 out
of 4 in the Crystal Structure of Human Kras G12C Covalently Bound to A Quinazolinone Inhibitor
Mono view Stereo pair view
Calcium binding site 2 out of 4 in 6pgpGo back to Calcium Binding Sites List in 6pgp
Calcium binding site 2 out
of 4 in the Crystal Structure of Human Kras G12C Covalently Bound to A Quinazolinone Inhibitor
Mono view Stereo pair view
Calcium binding site 3 out of 4 in 6pgpGo back to Calcium Binding Sites List in 6pgp
Calcium binding site 3 out
of 4 in the Crystal Structure of Human Kras G12C Covalently Bound to A Quinazolinone Inhibitor
Mono view Stereo pair view
Calcium binding site 4 out of 4 in 6pgpGo back to Calcium Binding Sites List in 6pgp
Calcium binding site 4 out
of 4 in the Crystal Structure of Human Kras G12C Covalently Bound to A Quinazolinone Inhibitor
Mono view Stereo pair view
Reference:
B.A.Lanman,
J.R.Allen,
J.G.Allen,
A.K.Amegadzie,
K.S.Ashton,
S.K.Booker,
J.J.Chen,
N.Chen,
M.J.Frohn,
G.Goodman,
D.J.Kopecky,
L.Liu,
P.Lopez,
J.D.Low,
V.Ma,
A.E.Minatti,
T.T.Nguyen,
N.Nishimura,
A.J.Pickrell,
A.B.Reed,
Y.Shin,
A.Siegmund,
N.A.Tamayo,
C.M.Tegley,
M.C.Walton,
H.L.Wang,
R.P.Wurz,
M.Xue,
K.C.Yang,
P.Achanta,
M.D.Bartberger,
J.Canon,
L.S.Hollis,
J.D.Mccarter,
C.Mohr,
K.Rex,
A.Y.Saiki,
T.San Miguel,
L.Volak,
K.H.Wang,
D.A.Whittington,
S.G.Zech,
J.R.Lipford,
V.J.Cee.
Discovery of A Covalent Inhibitor of KRASG12C (Amg 510) For the Treatment of Solid Tumors. J.Med.Chem. 2019.
Page generated: Tue Jul 16 12:51:57 2024
ISSN: ISSN 0022-2623 PubMed: 31820981 DOI: 10.1021/ACS.JMEDCHEM.9B01180 |
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