Calcium in PDB 6pus: Human TRPM2 Bound to Adpr and Calcium
Calcium Binding Sites:
The binding sites of Calcium atom in the Human TRPM2 Bound to Adpr and Calcium
(pdb code 6pus). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the
Human TRPM2 Bound to Adpr and Calcium, PDB code: 6pus:
Jump to Calcium binding site number:
1;
2;
3;
4;
Calcium binding site 1 out
of 4 in 6pus
Go back to
Calcium Binding Sites List in 6pus
Calcium binding site 1 out
of 4 in the Human TRPM2 Bound to Adpr and Calcium
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of Human TRPM2 Bound to Adpr and Calcium within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Ca1603
b:0.4
occ:1.00
|
OE2
|
A:GLU843
|
2.6
|
0.7
|
1.0
|
OE1
|
A:GLN846
|
2.6
|
0.8
|
1.0
|
NE2
|
A:GLN846
|
2.7
|
0.8
|
1.0
|
OD1
|
A:ASN869
|
2.8
|
0.2
|
1.0
|
CD
|
A:GLN846
|
3.0
|
0.8
|
1.0
|
OE1
|
A:GLU843
|
3.0
|
0.7
|
1.0
|
CD
|
A:GLU843
|
3.2
|
0.7
|
1.0
|
OE2
|
A:GLU1073
|
3.3
|
0.1
|
1.0
|
OD2
|
A:ASP872
|
3.9
|
30.0
|
1.0
|
CG
|
A:ASN869
|
4.0
|
0.2
|
1.0
|
NH2
|
A:ARG909
|
4.2
|
0.1
|
1.0
|
CG
|
A:GLN846
|
4.5
|
0.8
|
1.0
|
CD
|
A:GLU1073
|
4.5
|
0.1
|
1.0
|
OH
|
A:TYR863
|
4.6
|
0.6
|
1.0
|
CG
|
A:GLU843
|
4.7
|
0.7
|
1.0
|
ND2
|
A:ASN869
|
4.8
|
0.2
|
1.0
|
CA
|
A:ASN869
|
4.9
|
0.2
|
1.0
|
CG
|
A:ASP872
|
5.0
|
30.0
|
1.0
|
|
Calcium binding site 2 out
of 4 in 6pus
Go back to
Calcium Binding Sites List in 6pus
Calcium binding site 2 out
of 4 in the Human TRPM2 Bound to Adpr and Calcium
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 2 of Human TRPM2 Bound to Adpr and Calcium within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Ca1603
b:0.4
occ:1.00
|
OE2
|
C:GLU843
|
2.6
|
0.7
|
1.0
|
OE1
|
C:GLN846
|
2.6
|
0.8
|
1.0
|
NE2
|
C:GLN846
|
2.7
|
0.8
|
1.0
|
OD1
|
C:ASN869
|
2.8
|
0.2
|
1.0
|
CD
|
C:GLN846
|
3.0
|
0.8
|
1.0
|
OE1
|
C:GLU843
|
3.0
|
0.7
|
1.0
|
CD
|
C:GLU843
|
3.2
|
0.7
|
1.0
|
OE2
|
C:GLU1073
|
3.3
|
0.1
|
1.0
|
OD2
|
C:ASP872
|
3.9
|
30.0
|
1.0
|
CG
|
C:ASN869
|
4.0
|
0.2
|
1.0
|
NH2
|
C:ARG909
|
4.2
|
0.1
|
1.0
|
CG
|
C:GLN846
|
4.5
|
0.8
|
1.0
|
CD
|
C:GLU1073
|
4.5
|
0.1
|
1.0
|
OH
|
C:TYR863
|
4.6
|
0.6
|
1.0
|
CG
|
C:GLU843
|
4.7
|
0.7
|
1.0
|
ND2
|
C:ASN869
|
4.8
|
0.2
|
1.0
|
CA
|
C:ASN869
|
4.9
|
0.2
|
1.0
|
CG
|
C:ASP872
|
5.0
|
30.0
|
1.0
|
|
Calcium binding site 3 out
of 4 in 6pus
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Calcium Binding Sites List in 6pus
Calcium binding site 3 out
of 4 in the Human TRPM2 Bound to Adpr and Calcium
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 3 of Human TRPM2 Bound to Adpr and Calcium within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Ca1603
b:0.4
occ:1.00
|
OE2
|
D:GLU843
|
2.6
|
0.7
|
1.0
|
OE1
|
D:GLN846
|
2.6
|
0.8
|
1.0
|
NE2
|
D:GLN846
|
2.8
|
0.8
|
1.0
|
OD1
|
D:ASN869
|
2.8
|
0.2
|
1.0
|
CD
|
D:GLN846
|
3.0
|
0.8
|
1.0
|
OE1
|
D:GLU843
|
3.0
|
0.7
|
1.0
|
CD
|
D:GLU843
|
3.2
|
0.7
|
1.0
|
OE2
|
D:GLU1073
|
3.3
|
0.1
|
1.0
|
OD2
|
D:ASP872
|
3.9
|
30.0
|
1.0
|
CG
|
D:ASN869
|
4.0
|
0.2
|
1.0
|
NH2
|
D:ARG909
|
4.2
|
0.1
|
1.0
|
CG
|
D:GLN846
|
4.5
|
0.8
|
1.0
|
CD
|
D:GLU1073
|
4.5
|
0.1
|
1.0
|
OH
|
D:TYR863
|
4.6
|
0.6
|
1.0
|
CG
|
D:GLU843
|
4.7
|
0.7
|
1.0
|
ND2
|
D:ASN869
|
4.8
|
0.2
|
1.0
|
CA
|
D:ASN869
|
4.9
|
0.2
|
1.0
|
CG
|
D:ASP872
|
5.0
|
30.0
|
1.0
|
|
Calcium binding site 4 out
of 4 in 6pus
Go back to
Calcium Binding Sites List in 6pus
Calcium binding site 4 out
of 4 in the Human TRPM2 Bound to Adpr and Calcium
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 4 of Human TRPM2 Bound to Adpr and Calcium within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Ca1603
b:0.4
occ:1.00
|
OE2
|
B:GLU843
|
2.6
|
0.7
|
1.0
|
OE1
|
B:GLN846
|
2.6
|
0.8
|
1.0
|
NE2
|
B:GLN846
|
2.8
|
0.8
|
1.0
|
OD1
|
B:ASN869
|
2.8
|
0.2
|
1.0
|
CD
|
B:GLN846
|
3.0
|
0.8
|
1.0
|
OE1
|
B:GLU843
|
3.0
|
0.7
|
1.0
|
CD
|
B:GLU843
|
3.2
|
0.7
|
1.0
|
OE2
|
B:GLU1073
|
3.3
|
0.1
|
1.0
|
OD2
|
B:ASP872
|
3.9
|
30.0
|
1.0
|
CG
|
B:ASN869
|
4.0
|
0.2
|
1.0
|
NH2
|
B:ARG909
|
4.2
|
0.1
|
1.0
|
CG
|
B:GLN846
|
4.5
|
0.8
|
1.0
|
CD
|
B:GLU1073
|
4.5
|
0.1
|
1.0
|
OH
|
B:TYR863
|
4.6
|
0.6
|
1.0
|
CG
|
B:GLU843
|
4.7
|
0.7
|
1.0
|
ND2
|
B:ASN869
|
4.8
|
0.2
|
1.0
|
CA
|
B:ASN869
|
4.9
|
0.2
|
1.0
|
CG
|
B:ASP872
|
5.0
|
30.0
|
1.0
|
|
Reference:
Y.Huang,
B.Roth,
W.Lu,
J.Du.
Ligand Recognition and Gating Mechanism Through Three Ligand-Binding Sites of Human TRPM2 Channel. Elife V. 8 2019.
ISSN: ESSN 2050-084X
PubMed: 31513012
DOI: 10.7554/ELIFE.50175
Page generated: Tue Jul 16 13:05:45 2024
|