Calcium in PDB 6pus: Human TRPM2 Bound to Adpr and Calcium

The binding sites of Calcium atom in the Human TRPM2 Bound to Adpr and Calcium (pdb code 6pus). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Human TRPM2 Bound to Adpr and Calcium, PDB code: 6pus:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Human TRPM2 Bound to Adpr and Calcium


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human TRPM2 Bound to Adpr and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1603 b:0.4 occ:1.00 OE2 A:GLU843 2.6 0.7 1.0 OE1 A:GLN846 2.6 0.8 1.0 NE2 A:GLN846 2.7 0.8 1.0 OD1 A:ASN869 2.8 0.2 1.0 CD A:GLN846 3.0 0.8 1.0 OE1 A:GLU843 3.0 0.7 1.0 CD A:GLU843 3.2 0.7 1.0 OE2 A:GLU1073 3.3 0.1 1.0 OD2 A:ASP872 3.9 30.0 1.0 CG A:ASN869 4.0 0.2 1.0 NH2 A:ARG909 4.2 0.1 1.0 CG A:GLN846 4.5 0.8 1.0 CD A:GLU1073 4.5 0.1 1.0 OH A:TYR863 4.6 0.6 1.0 CG A:GLU843 4.7 0.7 1.0 ND2 A:ASN869 4.8 0.2 1.0 CA A:ASN869 4.9 0.2 1.0 CG A:ASP872 5.0 30.0 1.0

Calcium binding site 2 out of 4 in the Human TRPM2 Bound to Adpr and Calcium


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human TRPM2 Bound to Adpr and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1603 b:0.4 occ:1.00 OE2 C:GLU843 2.6 0.7 1.0 OE1 C:GLN846 2.6 0.8 1.0 NE2 C:GLN846 2.7 0.8 1.0 OD1 C:ASN869 2.8 0.2 1.0 CD C:GLN846 3.0 0.8 1.0 OE1 C:GLU843 3.0 0.7 1.0 CD C:GLU843 3.2 0.7 1.0 OE2 C:GLU1073 3.3 0.1 1.0 OD2 C:ASP872 3.9 30.0 1.0 CG C:ASN869 4.0 0.2 1.0 NH2 C:ARG909 4.2 0.1 1.0 CG C:GLN846 4.5 0.8 1.0 CD C:GLU1073 4.5 0.1 1.0 OH C:TYR863 4.6 0.6 1.0 CG C:GLU843 4.7 0.7 1.0 ND2 C:ASN869 4.8 0.2 1.0 CA C:ASN869 4.9 0.2 1.0 CG C:ASP872 5.0 30.0 1.0

Calcium binding site 3 out of 4 in the Human TRPM2 Bound to Adpr and Calcium


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Human TRPM2 Bound to Adpr and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1603 b:0.4 occ:1.00 OE2 D:GLU843 2.6 0.7 1.0 OE1 D:GLN846 2.6 0.8 1.0 NE2 D:GLN846 2.8 0.8 1.0 OD1 D:ASN869 2.8 0.2 1.0 CD D:GLN846 3.0 0.8 1.0 OE1 D:GLU843 3.0 0.7 1.0 CD D:GLU843 3.2 0.7 1.0 OE2 D:GLU1073 3.3 0.1 1.0 OD2 D:ASP872 3.9 30.0 1.0 CG D:ASN869 4.0 0.2 1.0 NH2 D:ARG909 4.2 0.1 1.0 CG D:GLN846 4.5 0.8 1.0 CD D:GLU1073 4.5 0.1 1.0 OH D:TYR863 4.6 0.6 1.0 CG D:GLU843 4.7 0.7 1.0 ND2 D:ASN869 4.8 0.2 1.0 CA D:ASN869 4.9 0.2 1.0 CG D:ASP872 5.0 30.0 1.0

Calcium binding site 4 out of 4 in the Human TRPM2 Bound to Adpr and Calcium


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Human TRPM2 Bound to Adpr and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1603 b:0.4 occ:1.00 OE2 B:GLU843 2.6 0.7 1.0 OE1 B:GLN846 2.6 0.8 1.0 NE2 B:GLN846 2.8 0.8 1.0 OD1 B:ASN869 2.8 0.2 1.0 CD B:GLN846 3.0 0.8 1.0 OE1 B:GLU843 3.0 0.7 1.0 CD B:GLU843 3.2 0.7 1.0 OE2 B:GLU1073 3.3 0.1 1.0 OD2 B:ASP872 3.9 30.0 1.0 CG B:ASN869 4.0 0.2 1.0 NH2 B:ARG909 4.2 0.1 1.0 CG B:GLN846 4.5 0.8 1.0 CD B:GLU1073 4.5 0.1 1.0 OH B:TYR863 4.6 0.6 1.0 CG B:GLU843 4.7 0.7 1.0 ND2 B:ASN869 4.8 0.2 1.0 CA B:ASN869 4.9 0.2 1.0 CG B:ASP872 5.0 30.0 1.0

Y.Huang, B.Roth, W.Lu, J.Du. Ligand Recognition and Gating Mechanism Through Three Ligand-Binding Sites of Human TRPM2 Channel. Elife V. 8 2019.
ISSN: ESSN 2050-084X
PubMed: 31513012
DOI: 10.7554/ELIFE.50175