Calcium in PDB 6puu: Human TRPM2 Bound to 8-Br-Cadpr and Calcium

The structure of Human TRPM2 Bound to 8-Br-Cadpr and Calcium also contains other interesting chemical elements:

Bromine

(Br)

4 atoms

The binding sites of Calcium atom in the Human TRPM2 Bound to 8-Br-Cadpr and Calcium (pdb code 6puu). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Human TRPM2 Bound to 8-Br-Cadpr and Calcium, PDB code: 6puu:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Human TRPM2 Bound to 8-Br-Cadpr and Calcium


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human TRPM2 Bound to 8-Br-Cadpr and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1602 b:0.0 occ:1.00 OE2 A:GLU843 2.6 0.1 1.0 OE1 A:GLN846 2.6 0.8 1.0 NE2 A:GLN846 2.7 0.8 1.0 CD A:GLN846 3.0 0.8 1.0 OD1 A:ASN869 3.3 0.0 1.0 OE2 A:GLU1073 3.4 0.1 1.0 CD A:GLU843 3.4 0.1 1.0 OE1 A:GLU843 3.5 0.1 1.0 CD A:GLU1073 4.4 0.1 1.0 CG A:ASN869 4.5 0.0 1.0 CG A:GLN846 4.5 0.8 1.0 OD2 A:ASP872 4.5 30.0 1.0 CG A:GLU843 4.9 0.1 1.0 NH2 A:ARG909 4.9 0.6 1.0

Calcium binding site 2 out of 4 in the Human TRPM2 Bound to 8-Br-Cadpr and Calcium


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human TRPM2 Bound to 8-Br-Cadpr and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1602 b:0.0 occ:1.00 OE2 B:GLU843 2.6 0.1 1.0 OE1 B:GLN846 2.6 0.8 1.0 NE2 B:GLN846 2.7 0.8 1.0 CD B:GLN846 3.0 0.8 1.0 OD1 B:ASN869 3.3 0.0 1.0 OE2 B:GLU1073 3.4 0.1 1.0 CD B:GLU843 3.4 0.1 1.0 OE1 B:GLU843 3.5 0.1 1.0 CD B:GLU1073 4.4 0.1 1.0 CG B:ASN869 4.5 0.0 1.0 CG B:GLN846 4.5 0.8 1.0 OD2 B:ASP872 4.5 30.0 1.0 CG B:GLU843 4.9 0.1 1.0 NH2 B:ARG909 4.9 0.6 1.0

Calcium binding site 3 out of 4 in the Human TRPM2 Bound to 8-Br-Cadpr and Calcium


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Human TRPM2 Bound to 8-Br-Cadpr and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1602 b:0.0 occ:1.00 OE2 C:GLU843 2.6 0.1 1.0 OE1 C:GLN846 2.6 0.8 1.0 NE2 C:GLN846 2.7 0.8 1.0 CD C:GLN846 3.0 0.8 1.0 OD1 C:ASN869 3.3 0.0 1.0 OE2 C:GLU1073 3.4 0.1 1.0 CD C:GLU843 3.4 0.1 1.0 OE1 C:GLU843 3.5 0.1 1.0 CD C:GLU1073 4.4 0.1 1.0 CG C:ASN869 4.5 0.0 1.0 CG C:GLN846 4.5 0.8 1.0 OD2 C:ASP872 4.5 30.0 1.0 CG C:GLU843 4.9 0.1 1.0 NH2 C:ARG909 4.9 0.6 1.0

Calcium binding site 4 out of 4 in the Human TRPM2 Bound to 8-Br-Cadpr and Calcium


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Human TRPM2 Bound to 8-Br-Cadpr and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1602 b:0.0 occ:1.00 OE2 D:GLU843 2.6 0.1 1.0 OE1 D:GLN846 2.6 0.8 1.0 NE2 D:GLN846 2.7 0.8 1.0 CD D:GLN846 3.0 0.8 1.0 OD1 D:ASN869 3.3 0.0 1.0 OE2 D:GLU1073 3.4 0.1 1.0 CD D:GLU843 3.4 0.1 1.0 OE1 D:GLU843 3.5 0.1 1.0 CD D:GLU1073 4.4 0.1 1.0 CG D:ASN869 4.5 0.0 1.0 CG D:GLN846 4.5 0.8 1.0 OD2 D:ASP872 4.5 30.0 1.0 CG D:GLU843 4.9 0.1 1.0 NH2 D:ARG909 4.9 0.6 1.0

Y.Huang, B.Roth, W.Lu, J.Du. Ligand Recognition and Gating Mechanism Through Three Ligand-Binding Sites of Human TRPM2 Channel. Elife V. 8 2019.
ISSN: ESSN 2050-084X
PubMed: 31513012
DOI: 10.7554/ELIFE.50175