Calcium in PDB 6r7x: Cryoem Structure of Calcium-Bound Human TMEM16K / Anoctamin 10 in Detergent (2MM CA2+, Closed Form)

The binding sites of Calcium atom in the Cryoem Structure of Calcium-Bound Human TMEM16K / Anoctamin 10 in Detergent (2MM CA2+, Closed Form) (pdb code 6r7x). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 6 binding sites of Calcium where determined in the Cryoem Structure of Calcium-Bound Human TMEM16K / Anoctamin 10 in Detergent (2MM CA2+, Closed Form), PDB code: 6r7x:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6;

Calcium binding site 1 out of 6 in the Cryoem Structure of Calcium-Bound Human TMEM16K / Anoctamin 10 in Detergent (2MM CA2+, Closed Form)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryoem Structure of Calcium-Bound Human TMEM16K / Anoctamin 10 in Detergent (2MM CA2+, Closed Form) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca701 b:29.0 occ:1.00 OE2 A:GLU500 2.3 20.9 1.0 OE1 A:GLU529 2.5 28.8 1.0 OE1 A:GLN445 2.7 29.9 1.0 OE1 A:GLU448 2.8 31.6 1.0 OE2 A:GLU529 2.8 28.8 1.0 CD A:GLU500 2.9 20.9 1.0 OE1 A:GLU500 2.9 20.9 1.0 OD1 A:ASN444 2.9 28.3 1.0 CD A:GLU529 3.0 28.8 1.0 CG A:ASN444 3.1 28.3 1.0 CD A:GLN445 3.4 29.9 1.0 CG A:GLN445 3.5 29.9 1.0 CB A:ASN444 3.5 28.3 1.0 N A:GLN445 3.6 29.9 1.0 C A:ASN444 3.6 28.3 1.0 ND2 A:ASN444 3.8 28.3 1.0 CA A:GLN445 3.9 29.9 1.0 O A:ASN444 3.9 28.3 1.0 CD A:GLU448 4.0 31.6 1.0 CA A:ASN444 4.2 28.3 1.0 CB A:GLN445 4.3 29.9 1.0 CG A:GLU500 4.3 20.9 1.0 O A:GLN441 4.4 24.5 1.0 CG A:GLU529 4.5 28.8 1.0 NE2 A:GLN445 4.5 29.9 1.0 CA A:CA702 4.6 19.8 1.0 OE2 A:GLU448 4.7 31.6 1.0 CB A:GLU448 4.8 31.6 1.0 ND2 A:ASN525 4.8 27.2 1.0 CG A:GLU448 5.0 31.6 1.0

Calcium binding site 2 out of 6 in the Cryoem Structure of Calcium-Bound Human TMEM16K / Anoctamin 10 in Detergent (2MM CA2+, Closed Form)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryoem Structure of Calcium-Bound Human TMEM16K / Anoctamin 10 in Detergent (2MM CA2+, Closed Form) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca702 b:19.8 occ:1.00 OE2 A:GLU448 2.3 31.6 1.0 OE2 A:GLU529 2.5 28.8 1.0 OD2 A:ASP533 2.5 28.3 1.0 OD1 A:ASP533 2.7 28.3 1.0 OD1 A:ASP497 2.7 19.7 1.0 CG A:ASP533 3.0 28.3 1.0 OE1 A:GLU500 3.0 20.9 1.0 CD A:GLU448 3.2 31.6 1.0 OE1 A:GLU448 3.3 31.6 1.0 OH A:TYR211 3.4 16.1 1.0 CD A:GLU529 3.6 28.8 1.0 CG A:ASP497 3.7 19.7 1.0 NZ A:LYS536 3.7 27.3 1.0 CD A:GLU500 3.8 20.9 1.0 CA A:ASP497 4.0 19.7 1.0 CB A:ASP497 4.0 19.7 1.0 CG A:GLU529 4.1 28.8 1.0 OE2 A:GLU500 4.3 20.9 1.0 CB A:ASP533 4.5 28.3 1.0 CZ A:TYR211 4.5 16.1 1.0 O A:ASP497 4.5 19.7 1.0 CG A:GLU448 4.6 31.6 1.0 CA A:CA701 4.6 29.0 1.0 OE1 A:GLU529 4.6 28.8 1.0 CB A:GLU500 4.7 20.9 1.0 OD2 A:ASP497 4.8 19.7 1.0 CG A:GLU500 4.8 20.9 1.0 C A:ASP497 4.8 19.7 1.0 N A:ASP497 5.0 19.7 1.0 CE A:LYS536 5.0 27.3 1.0

Calcium binding site 3 out of 6 in the Cryoem Structure of Calcium-Bound Human TMEM16K / Anoctamin 10 in Detergent (2MM CA2+, Closed Form)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Cryoem Structure of Calcium-Bound Human TMEM16K / Anoctamin 10 in Detergent (2MM CA2+, Closed Form) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca703 b:25.1 occ:1.00 O A:ALA610 2.4 25.7 1.0 O A:ILE613 2.5 27.5 1.0 OD1 A:ASP615 2.5 36.2 1.0 OE2 A:GLU259 2.6 24.9 1.0 CD A:GLU259 3.3 24.9 1.0 OE1 A:GLU259 3.5 24.9 1.0 C A:ALA610 3.6 25.7 1.0 CG A:ASP615 3.7 36.2 1.0 C A:ILE613 3.8 27.5 1.0 N A:ASP615 4.3 36.2 1.0 CA A:PHE611 4.3 28.7 1.0 OD2 A:ASP615 4.3 36.2 1.0 O A:PHE611 4.3 28.7 1.0 NZ A:LYS262 4.3 20.8 1.0 C A:PHE611 4.4 28.7 1.0 C A:PRO614 4.4 31.2 1.0 N A:PHE611 4.4 28.7 1.0 CA A:PRO614 4.4 31.2 1.0 N A:PRO614 4.6 31.2 1.0 CG A:GLU259 4.6 24.9 1.0 CA A:ALA610 4.6 25.7 1.0 N A:ILE613 4.7 27.5 1.0 CA A:ILE613 4.7 27.5 1.0 CA A:ASP615 4.8 36.2 1.0 CB A:ASP615 4.9 36.2 1.0 O A:PRO614 4.9 31.2 1.0

Calcium binding site 4 out of 6 in the Cryoem Structure of Calcium-Bound Human TMEM16K / Anoctamin 10 in Detergent (2MM CA2+, Closed Form)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Cryoem Structure of Calcium-Bound Human TMEM16K / Anoctamin 10 in Detergent (2MM CA2+, Closed Form) within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca902 b:28.6 occ:1.00 OE2 B:GLU500 2.3 21.0 1.0 OE1 B:GLU529 2.5 29.0 1.0 OE1 B:GLN445 2.7 29.8 1.0 OE1 B:GLU448 2.8 31.5 1.0 OE2 B:GLU529 2.8 29.0 1.0 CD B:GLU500 2.9 21.0 1.0 OE1 B:GLU500 2.9 21.0 1.0 OD1 B:ASN444 2.9 28.3 1.0 CD B:GLU529 3.0 29.0 1.0 CG B:ASN444 3.1 28.3 1.0 CD B:GLN445 3.4 29.8 1.0 CG B:GLN445 3.5 29.8 1.0 CB B:ASN444 3.5 28.3 1.0 N B:GLN445 3.6 29.8 1.0 C B:ASN444 3.6 28.3 1.0 ND2 B:ASN444 3.8 28.3 1.0 CA B:GLN445 3.9 29.8 1.0 O B:ASN444 3.9 28.3 1.0 CD B:GLU448 4.0 31.5 1.0 CA B:ASN444 4.2 28.3 1.0 CB B:GLN445 4.3 29.8 1.0 CG B:GLU500 4.3 21.0 1.0 O B:GLN441 4.4 24.4 1.0 CG B:GLU529 4.5 29.0 1.0 NE2 B:GLN445 4.5 29.8 1.0 CA B:CA903 4.6 19.9 1.0 OE2 B:GLU448 4.7 31.5 1.0 CB B:GLU448 4.8 31.5 1.0 ND2 B:ASN525 4.8 27.4 1.0 CG B:GLU448 5.0 31.5 1.0

Calcium binding site 5 out of 6 in the Cryoem Structure of Calcium-Bound Human TMEM16K / Anoctamin 10 in Detergent (2MM CA2+, Closed Form)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Cryoem Structure of Calcium-Bound Human TMEM16K / Anoctamin 10 in Detergent (2MM CA2+, Closed Form) within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca903 b:19.9 occ:1.00 OE2 B:GLU448 2.3 31.5 1.0 OE2 B:GLU529 2.5 29.0 1.0 OD2 B:ASP533 2.5 28.4 1.0 OD1 B:ASP533 2.7 28.4 1.0 OD1 B:ASP497 2.7 20.0 1.0 CG B:ASP533 3.0 28.4 1.0 OE1 B:GLU500 3.0 21.0 1.0 CD B:GLU448 3.2 31.5 1.0 OE1 B:GLU448 3.3 31.5 1.0 OH B:TYR211 3.4 16.1 1.0 CD B:GLU529 3.6 29.0 1.0 CG B:ASP497 3.7 20.0 1.0 NZ B:LYS536 3.7 27.3 1.0 CD B:GLU500 3.8 21.0 1.0 CA B:ASP497 4.0 20.0 1.0 CB B:ASP497 4.0 20.0 1.0 CG B:GLU529 4.1 29.0 1.0 OE2 B:GLU500 4.3 21.0 1.0 CB B:ASP533 4.5 28.4 1.0 CZ B:TYR211 4.5 16.1 1.0 O B:ASP497 4.5 20.0 1.0 CG B:GLU448 4.6 31.5 1.0 CA B:CA902 4.6 28.6 1.0 OE1 B:GLU529 4.6 29.0 1.0 CB B:GLU500 4.7 21.0 1.0 OD2 B:ASP497 4.8 20.0 1.0 CG B:GLU500 4.8 21.0 1.0 C B:ASP497 4.8 20.0 1.0 N B:ASP497 5.0 20.0 1.0 CE B:LYS536 5.0 27.3 1.0

Calcium binding site 6 out of 6 in the Cryoem Structure of Calcium-Bound Human TMEM16K / Anoctamin 10 in Detergent (2MM CA2+, Closed Form)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Cryoem Structure of Calcium-Bound Human TMEM16K / Anoctamin 10 in Detergent (2MM CA2+, Closed Form) within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca904 b:24.7 occ:1.00 O B:ALA610 2.4 25.3 1.0 O B:ILE613 2.5 27.0 1.0 OD1 B:ASP615 2.5 35.5 1.0 OE2 B:GLU259 2.6 24.2 1.0 CD B:GLU259 3.3 24.2 1.0 OE1 B:GLU259 3.5 24.2 1.0 C B:ALA610 3.6 25.3 1.0 CG B:ASP615 3.7 35.5 1.0 C B:ILE613 3.8 27.0 1.0 N B:ASP615 4.3 35.5 1.0 CA B:PHE611 4.3 28.4 1.0 OD2 B:ASP615 4.3 35.5 1.0 NZ B:LYS262 4.3 20.4 1.0 O B:PHE611 4.3 28.4 1.0 C B:PHE611 4.4 28.4 1.0 C B:PRO614 4.4 30.7 1.0 N B:PHE611 4.4 28.4 1.0 CA B:PRO614 4.4 30.7 1.0 N B:PRO614 4.6 30.7 1.0 CG B:GLU259 4.6 24.2 1.0 CA B:ALA610 4.6 25.3 1.0 N B:ILE613 4.7 27.0 1.0 CA B:ILE613 4.7 27.0 1.0 CA B:ASP615 4.8 35.5 1.0 CB B:ASP615 4.9 35.5 1.0 O B:PRO614 4.9 30.7 1.0

S.R.Bushell, A.C.W.Pike, M.E.Falzone, N.J.G.Rorsman, C.M.Ta, R.A.Corey, T.D.Newport, J.C.Christianson, L.F.Scofano, C.A.Shintre, A.Tessitore, A.Chu, Q.Wang, L.Shrestha, S.M.M.Mukhopadhyay, J.D.Love, N.A.Burgess-Brown, R.Sitsapesan, P.J.Stansfeld, J.T.Huiskonen, P.Tammaro, A.Accardi, E.P.Carpenter. The Structural Basis of Lipid Scrambling and Inactivation in the Endoplasmic Reticulum Scramblase TMEM16K. Nat Commun V. 10 3956 2019.
ISSN: ESSN 2041-1723
PubMed: 31477691
DOI: 10.1038/S41467-019-11753-1