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Calcium in PDB 6sgp: X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu

Enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu

All present enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu:
3.4.17.21;

Protein crystallography data

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu, PDB code: 6sgp was solved by C.Barinka, S.Shukla, L.Motlova, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.90 / 1.58
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 101.349, 130.394, 158.538, 90.00, 90.00, 90.00
R / Rfree (%) 18 / 20.1

Other elements in 6sgp:

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu also contains other interesting chemical elements:

Zinc (Zn) 2 atoms
Chlorine (Cl) 1 atom
Sodium (Na) 1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu (pdb code 6sgp). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu, PDB code: 6sgp:

Calcium binding site 1 out of 1 in 6sgp

Go back to Calcium Binding Sites List in 6sgp
Calcium binding site 1 out of 1 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca821

b:18.9
occ:1.00
 O A:TYR272 2.3 19.9 1.0
OE2 A:GLU436 2.3 19.7 1.0
O A:HOH965 2.4 18.8 1.0
O A:THR269 2.4 19.0 1.0
OE2 A:GLU433 2.4 19.1 1.0
OE1 A:GLU433 2.5 19.6 1.0
OG1 A:THR269 2.5 18.8 1.0
CD A:GLU433 2.8 18.8 1.0
C A:THR269 3.3 19.0 1.0
CB A:THR269 3.3 19.9 1.0
C A:TYR272 3.4 18.8 1.0
CD A:GLU436 3.5 19.2 1.0
OE1 A:GLU436 3.9 18.2 1.0
CA A:THR269 3.9 19.9 1.0
N A:TYR272 4.0 18.6 1.0
CB A:ASP266 4.2 19.1 1.0
CA A:PRO273 4.2 20.2 1.0
N A:PRO270 4.2 19.4 1.0
N A:ALA274 4.3 18.9 1.0
N A:PRO273 4.3 19.5 1.0
CG A:GLU433 4.3 18.4 1.0
CA A:TYR272 4.4 19.2 1.0
C A:PRO273 4.4 20.9 1.0
N A:ASP266 4.5 18.0 1.0
CA A:PRO270 4.5 18.4 1.0
N A:GLY271 4.5 19.2 1.0
O A:ASP266 4.5 19.9 1.0
O A:ALA264 4.6 21.5 1.0
N A:THR269 4.6 19.7 1.0
CG2 A:THR269 4.7 20.8 1.0
CG A:GLU436 4.7 18.5 1.0
C A:PRO270 4.7 19.4 1.0
OD2 A:ASP266 4.8 21.6 1.0
CA A:ASP266 4.8 20.0 1.0
CB A:ALA274 4.9 21.3 1.0
CB A:GLU436 4.9 19.2 1.0
CA A:GLU433 5.0 17.9 1.0
C A:GLY271 5.0 19.3 1.0

Reference:

C.Barinka, S.Shukla, L.Motlova. X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu To Be Published.
Page generated: Tue Jul 16 14:47:19 2024

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