Calcium in PDB 6sz5: Human Calmodulin Bound to A Peptide of Human Nadph Oxidase 5

The structure of Human Calmodulin Bound to A Peptide of Human Nadph Oxidase 5, PDB code: 6sz5 was solved by E.Millana, A.Mattevi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.21 / 2.23
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	24.759, 60.840, 102.444, 90.00, 90.00, 90.00
R / Rfree (%)	21.9 / 29.4

The binding sites of Calcium atom in the Human Calmodulin Bound to A Peptide of Human Nadph Oxidase 5 (pdb code 6sz5). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Human Calmodulin Bound to A Peptide of Human Nadph Oxidase 5, PDB code: 6sz5:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Human Calmodulin Bound to A Peptide of Human Nadph Oxidase 5


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Calmodulin Bound to A Peptide of Human Nadph Oxidase 5 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca501 b:32.1 occ:1.00 OD1 A:ASP134 2.2 35.4 1.0 OD1 A:ASP130 2.3 38.4 1.0 O A:GLN136 2.3 31.2 1.0 OD1 A:ASP132 2.4 33.8 1.0 OE2 A:GLU141 2.5 29.6 1.0 OE1 A:GLU141 2.5 33.5 1.0 CD A:GLU141 2.8 32.5 1.0 CG A:ASP134 3.2 35.9 1.0 CG A:ASP132 3.3 39.0 1.0 CG A:ASP130 3.3 37.9 1.0 C A:GLN136 3.5 29.1 1.0 OD2 A:ASP132 3.7 44.5 1.0 OD2 A:ASP134 3.7 39.9 1.0 N A:ASP134 4.1 32.8 1.0 CB A:ASP130 4.1 35.6 1.0 CA A:ASP130 4.1 35.5 1.0 N A:GLN136 4.1 30.4 1.0 OD2 A:ASP130 4.2 35.0 1.0 CB A:ASP134 4.3 36.0 1.0 CG A:GLU141 4.3 32.2 1.0 N A:ASN138 4.3 28.4 1.0 N A:ASP132 4.4 35.0 1.0 CA A:GLN136 4.4 30.9 1.0 N A:VAL137 4.5 27.1 1.0 CA A:VAL137 4.5 28.9 1.0 N A:ILE131 4.5 35.8 1.0 N A:GLY133 4.6 37.6 1.0 N A:GLY135 4.6 34.0 1.0 C A:ASP130 4.6 37.2 1.0 CB A:ASP132 4.6 38.4 1.0 CA A:ASP134 4.6 35.4 1.0 ND2 A:ASN138 4.7 27.4 1.0 CG A:ASN138 4.8 30.8 1.0 C A:VAL137 4.9 28.1 1.0 CA A:ASP132 4.9 36.1 1.0 C A:ASP134 4.9 35.6 1.0 C A:ASP132 4.9 36.0 1.0 CB A:GLN136 5.0 32.7 1.0 CB A:ASN138 5.0 28.4 1.0

Calcium binding site 2 out of 4 in the Human Calmodulin Bound to A Peptide of Human Nadph Oxidase 5


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human Calmodulin Bound to A Peptide of Human Nadph Oxidase 5 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca502 b:35.0 occ:1.00 OD1 A:ASP96 2.2 34.4 1.0 O A:TYR100 2.3 33.3 1.0 OD1 A:ASP94 2.3 31.9 1.0 OD1 A:ASN98 2.3 32.7 1.0 OE2 A:GLU105 2.4 35.8 1.0 OE1 A:GLU105 2.6 33.4 1.0 CD A:GLU105 2.8 33.2 1.0 CG A:ASP96 3.3 35.6 1.0 CG A:ASN98 3.4 30.5 1.0 CG A:ASP94 3.4 29.8 1.0 C A:TYR100 3.4 27.8 1.0 OD2 A:ASP96 3.8 34.5 1.0 ND2 A:ASN98 4.1 27.7 1.0 N A:ASN98 4.2 30.9 1.0 CA A:ASP94 4.2 34.4 1.0 OD2 A:ASP94 4.2 32.7 1.0 N A:TYR100 4.2 29.2 1.0 CB A:ASP94 4.3 32.0 1.0 N A:ASP96 4.3 38.9 1.0 CG A:GLU105 4.3 30.3 1.0 N A:ILE101 4.3 26.9 1.0 CA A:TYR100 4.4 31.0 1.0 C A:ASP94 4.4 35.9 1.0 N A:GLY97 4.4 33.5 1.0 CA A:ILE101 4.4 26.9 1.0 N A:SER102 4.5 29.4 1.0 CB A:ASN98 4.5 30.8 1.0 CB A:ASP96 4.5 33.4 1.0 N A:LYS95 4.6 38.7 1.0 N A:GLY99 4.8 27.4 1.0 CA A:ASP96 4.8 34.5 1.0 CA A:ASN98 4.8 30.2 1.0 O A:ASP94 4.8 35.7 1.0 C A:ASP96 4.9 34.7 1.0 CB A:TYR100 4.9 31.5 1.0 C A:ILE101 4.9 29.1 1.0

Calcium binding site 3 out of 4 in the Human Calmodulin Bound to A Peptide of Human Nadph Oxidase 5


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Human Calmodulin Bound to A Peptide of Human Nadph Oxidase 5 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca503 b:47.0 occ:1.00 OD2 A:ASP59 2.3 63.7 1.0 OD1 A:ASP57 2.4 42.6 1.0 O A:THR63 2.4 40.0 1.0 OE1 A:GLU68 2.5 37.8 1.0 OD1 A:ASN61 2.6 40.9 1.0 OE2 A:GLU68 2.7 46.6 1.0 CD A:GLU68 2.9 41.2 1.0 CG A:ASP59 3.1 59.7 1.0 CB A:ASP59 3.2 53.7 1.0 CG A:ASN61 3.3 45.8 1.0 ND2 A:ASN61 3.4 42.8 1.0 C A:THR63 3.5 38.5 1.0 CG A:ASP57 3.5 43.4 1.0 OG1 A:THR63 4.1 51.1 1.0 N A:ASP59 4.2 55.9 1.0 OD2 A:ASP57 4.3 45.9 1.0 OD1 A:ASP59 4.3 69.7 1.0 N A:ILE64 4.3 36.9 1.0 N A:THR63 4.3 41.2 1.0 CA A:ASP59 4.3 53.9 1.0 CA A:ILE64 4.4 39.3 1.0 CA A:THR63 4.4 43.2 1.0 N A:ASP65 4.4 33.8 1.0 CG A:GLU68 4.5 40.4 1.0 CB A:ASN61 4.5 47.0 1.0 CA A:ASP57 4.6 46.5 1.0 CB A:ASP57 4.6 47.5 1.0 N A:ASN61 4.6 56.7 1.0 OD1 A:ASP65 4.7 40.9 1.0 C A:ILE64 4.8 36.4 1.0 CG A:ASP65 4.9 41.2 1.0 CB A:THR63 4.9 48.0 1.0 N A:GLY60 4.9 50.6 1.0 N A:ALA58 4.9 52.6 1.0 O A:HOH628 4.9 40.8 1.0 C A:ASP57 5.0 50.2 1.0 CA A:ASN61 5.0 49.9 1.0

Calcium binding site 4 out of 4 in the Human Calmodulin Bound to A Peptide of Human Nadph Oxidase 5


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Human Calmodulin Bound to A Peptide of Human Nadph Oxidase 5 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca504 b:29.8 occ:1.00 O A:THR27 2.3 35.4 1.0 OD1 A:ASP25 2.3 38.6 1.0 OD1 A:ASP21 2.4 39.3 1.0 OD1 A:ASP23 2.5 31.6 1.0 OE1 A:GLU32 2.6 29.8 1.0 OE2 A:GLU32 2.8 28.1 1.0 CD A:GLU32 3.1 29.9 1.0 CG A:ASP25 3.3 42.6 1.0 CG A:ASP21 3.4 35.5 1.0 C A:THR27 3.5 34.8 1.0 CG A:ASP23 3.6 31.0 1.0 OG1 A:THR27 4.0 33.6 1.0 N A:THR27 4.1 36.6 1.0 OD2 A:ASP23 4.1 29.9 1.0 CA A:ASP21 4.1 38.5 1.0 OD2 A:ASP25 4.1 42.2 1.0 CB A:ASP25 4.2 39.7 1.0 CB A:ASP21 4.2 38.7 1.0 N A:ASP25 4.2 38.6 1.0 OD2 A:ASP21 4.3 39.7 1.0 CA A:THR27 4.3 33.7 1.0 N A:ILE28 4.4 32.5 1.0 C A:ASP21 4.4 39.6 1.0 CG A:GLU32 4.6 28.3 1.0 CA A:ILE28 4.6 32.9 1.0 N A:ASP23 4.6 36.2 1.0 CA A:ASP25 4.7 37.6 1.0 N A:GLY26 4.7 37.7 1.0 N A:LYS22 4.7 41.3 1.0 N A:GLY24 4.7 36.2 1.0 CB A:ASP23 4.8 33.9 1.0 CB A:THR27 4.8 34.3 1.0 O A:ASP21 4.9 41.0 1.0 CG2 A:THR29 4.9 28.1 1.0 C A:ASP25 5.0 39.7 1.0

E.Millana-Fananas, S.Todesca, A.Siccorello, L.Masino, P.Pompach, F.Magnani, A.Pastore, A.Mattevi. On the Mechanism of Calcium-Dependent Activation of Nadph Oxidase 5 (NOX5). Febs J. 2019.
ISSN: ISSN 1742-464X
PubMed: 31785178
DOI: 10.1111/FEBS.15160