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Calcium in PDB 6twa: Human CD73 (Ecto 5'-Nucleotidase) in Complex with PSB12646 (An Aopcp Derivative, Compound 20 in Publication) in the Closed StateEnzymatic activity of Human CD73 (Ecto 5'-Nucleotidase) in Complex with PSB12646 (An Aopcp Derivative, Compound 20 in Publication) in the Closed State
All present enzymatic activity of Human CD73 (Ecto 5'-Nucleotidase) in Complex with PSB12646 (An Aopcp Derivative, Compound 20 in Publication) in the Closed State:
3.1.3.5; Protein crystallography data
The structure of Human CD73 (Ecto 5'-Nucleotidase) in Complex with PSB12646 (An Aopcp Derivative, Compound 20 in Publication) in the Closed State, PDB code: 6twa
was solved by
J.Pippel,
N.Strater,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6twa:
The structure of Human CD73 (Ecto 5'-Nucleotidase) in Complex with PSB12646 (An Aopcp Derivative, Compound 20 in Publication) in the Closed State also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the Human CD73 (Ecto 5'-Nucleotidase) in Complex with PSB12646 (An Aopcp Derivative, Compound 20 in Publication) in the Closed State
(pdb code 6twa). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Human CD73 (Ecto 5'-Nucleotidase) in Complex with PSB12646 (An Aopcp Derivative, Compound 20 in Publication) in the Closed State, PDB code: 6twa: Calcium binding site 1 out of 1 in 6twaGo back to Calcium Binding Sites List in 6twa
Calcium binding site 1 out
of 1 in the Human CD73 (Ecto 5'-Nucleotidase) in Complex with PSB12646 (An Aopcp Derivative, Compound 20 in Publication) in the Closed State
Mono view Stereo pair view
Reference:
S.Bhattarai,
J.Pippel,
E.R.Scaletti,
R.Idris,
M.Freundlieb,
G.Rolshoven,
C.Renn,
S.Y.Lee,
A.Abdelrahman,
H.Zimmermann,
A.El-Tayeb,
C.E.Muller,
N.Strater.
2-Substituted Alpha , Beta Methylene-Adp Derivatives: Potent Competitive Ecto-5'-Nucleotidase (CD73) Inhibitors with Variable Binding Modes. J.Med.Chem. 2020.
Page generated: Sat Dec 12 07:46:00 2020
ISSN: ISSN 0022-2623 PubMed: 32045236 DOI: 10.1021/ACS.JMEDCHEM.9B01611 |
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