Calcium in PDB 6xar: Structure of Cbl Tyrosine Kinase Binding Domain (Tkbd) with C-Terminal Tail of Src-Like Kinase Protein 2 (SLAP2)

All present enzymatic activity of Structure of Cbl Tyrosine Kinase Binding Domain (Tkbd) with C-Terminal Tail of Src-Like Kinase Protein 2 (SLAP2):
2.3.2.27;

The structure of Structure of Cbl Tyrosine Kinase Binding Domain (Tkbd) with C-Terminal Tail of Src-Like Kinase Protein 2 (SLAP2), PDB code: 6xar was solved by L.E.Wybenga-Groot, C.J.Mcglade, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.32 / 2.50
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	62.73, 86.96, 65.26, 90, 112.31, 90
R / Rfree (%)	24.9 / 29.3

The binding sites of Calcium atom in the Structure of Cbl Tyrosine Kinase Binding Domain (Tkbd) with C-Terminal Tail of Src-Like Kinase Protein 2 (SLAP2) (pdb code 6xar). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Structure of Cbl Tyrosine Kinase Binding Domain (Tkbd) with C-Terminal Tail of Src-Like Kinase Protein 2 (SLAP2), PDB code: 6xar:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Structure of Cbl Tyrosine Kinase Binding Domain (Tkbd) with C-Terminal Tail of Src-Like Kinase Protein 2 (SLAP2)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Cbl Tyrosine Kinase Binding Domain (Tkbd) with C-Terminal Tail of Src-Like Kinase Protein 2 (SLAP2) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca401 b:48.6 occ:1.00 OG1 A:THR231 2.4 33.5 1.0 O A:TYR235 2.4 32.9 1.0 OD1 A:ASP229 2.5 31.3 1.0 OE2 A:GLU240 2.5 28.7 1.0 OE1 A:GLU240 2.5 28.1 1.0 OD1 A:ASN233 2.5 38.4 1.0 CD A:GLU240 2.8 27.2 1.0 C A:TYR235 3.4 38.7 1.0 CG A:ASN233 3.6 31.7 1.0 CG A:ASP229 3.7 32.2 1.0 CB A:THR231 3.7 35.0 1.0 N A:THR231 4.0 30.7 1.0 ND2 A:ASN233 4.1 33.6 1.0 N A:ILE236 4.2 33.3 1.0 CG2 A:THR231 4.2 33.3 1.0 CA A:TYR235 4.2 39.1 1.0 N A:TYR235 4.3 39.3 1.0 CA A:THR231 4.3 32.8 1.0 CA A:ASP229 4.3 29.8 1.0 CA A:ILE236 4.3 29.4 1.0 CG A:GLU240 4.3 25.6 1.0 N A:CYS232 4.4 30.8 1.0 CB A:TYR235 4.4 37.3 1.0 N A:LEU230 4.5 27.7 1.0 C A:ASP229 4.5 27.0 1.0 N A:ASN233 4.5 32.8 1.0 OE2 A:GLU164 4.5 39.0 1.0 CB A:ASP229 4.6 30.6 1.0 OD2 A:ASP229 4.6 33.5 1.0 C A:THR231 4.6 31.2 1.0 N A:SER237 4.7 29.3 1.0 CD1 A:ILE236 4.8 27.8 1.0 CB A:ASN233 4.8 31.2 1.0 C A:ILE236 5.0 28.8 1.0

Calcium binding site 2 out of 2 in the Structure of Cbl Tyrosine Kinase Binding Domain (Tkbd) with C-Terminal Tail of Src-Like Kinase Protein 2 (SLAP2)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Cbl Tyrosine Kinase Binding Domain (Tkbd) with C-Terminal Tail of Src-Like Kinase Protein 2 (SLAP2) within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca401 b:50.6 occ:1.00 OD1 B:ASN233 2.5 49.1 1.0 O B:TYR235 2.5 53.8 1.0 OG1 B:THR231 2.5 46.1 1.0 OE1 B:GLU240 2.5 56.1 1.0 OE2 B:GLU240 2.6 42.2 1.0 OD1 B:ASP229 2.7 43.6 1.0 CD B:GLU240 2.9 47.3 1.0 C B:TYR235 3.4 49.2 1.0 CG B:ASN233 3.4 45.8 1.0 ND2 B:ASN233 3.8 41.7 1.0 CB B:THR231 3.8 39.4 1.0 CG B:ASP229 3.9 42.8 1.0 CA B:TYR235 4.2 48.6 1.0 N B:THR231 4.2 33.9 1.0 N B:TYR235 4.2 46.6 1.0 CB B:TYR235 4.3 54.0 1.0 CG2 B:THR231 4.3 33.6 1.0 N B:ILE236 4.3 48.3 1.0 CG B:GLU240 4.4 41.5 1.0 OE2 B:GLU164 4.4 54.0 1.0 CA B:THR231 4.5 41.2 1.0 CA B:ILE236 4.5 55.4 1.0 CA B:ASP229 4.6 33.9 1.0 N B:ASN233 4.6 44.1 1.0 N B:CYS232 4.6 39.7 1.0 N B:LEU230 4.7 34.8 1.0 OD2 B:ASP229 4.7 42.0 1.0 CB B:ASN233 4.7 46.1 1.0 N B:SER237 4.8 51.2 1.0 CB B:ASP229 4.8 36.9 1.0 C B:ASP229 4.8 33.6 1.0 C B:THR231 4.8 35.7 1.0

L.E.Wybenga-Groot, A.J.Tench, C.D.Simpson, J.St.Germain, B.Raught, M.F.Moran, C.J.Mcglade. Structural Basis For Phosphorylation Independent Activation of C-Cbl By Src-Like Adaptor Protein 2 J.Mol.Biol. 2021.
ISSN: ESSN 1089-8638
DOI: 10.1016/J.JMB.2021.166880