Calcium in PDB 6xsw: Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment

The structure of Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment, PDB code: 6xsw was solved by J.Bard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	112.66 / 2.98
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	133.652, 158.951, 159.687, 90, 90, 90
R / Rfree (%)	23.3 / 25.6

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 13;

Binding sites:

The binding sites of Calcium atom in the Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment (pdb code 6xsw). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 13 binding sites of Calcium where determined in the Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment, PDB code: 6xsw:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Calcium binding site 1 out of 13 in the Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1701 b:47.3 occ:1.00 OD1 C:ASP1399 2.1 45.6 1.0 O C:LYS1396 2.2 51.9 1.0 OD2 C:ASP1403 2.3 52.6 1.0 O C:ARG1401 2.4 41.8 1.0 OD2 C:ASP1414 2.5 54.4 1.0 OD2 C:ASP1417 2.6 52.0 1.0 OD1 C:ASP1414 2.7 53.3 1.0 CG C:ASP1414 2.9 52.5 1.0 CG C:ASP1399 3.1 48.1 1.0 C C:LYS1396 3.4 51.3 1.0 CG C:ASP1403 3.5 48.1 1.0 C C:ARG1401 3.6 42.1 1.0 CG C:ASP1417 3.6 46.9 1.0 OD2 C:ASP1399 3.6 57.3 1.0 CB C:ASP1417 4.0 41.6 1.0 N C:ASP1399 4.0 40.3 1.0 CB C:LYS1396 4.1 50.5 1.0 CA C:LYS1396 4.1 48.7 1.0 CB C:ASP1399 4.2 41.0 1.0 N C:ARG1401 4.2 37.4 1.0 N C:ASP1403 4.2 43.0 1.0 CB C:ASP1403 4.3 43.8 1.0 O C:ASP1414 4.3 50.3 1.0 CB C:ASP1414 4.3 48.4 1.0 CA C:ARG1401 4.4 36.9 1.0 N C:ARG1397 4.4 45.8 1.0 OD1 C:ASP1403 4.4 47.9 1.0 N C:GLY1398 4.5 42.3 1.0 CA C:ASP1399 4.6 39.6 1.0 CB C:ARG1401 4.6 33.9 1.0 N C:CYS1402 4.6 40.8 1.0 OD1 C:ASP1417 4.7 45.9 1.0 CA C:ARG1397 4.7 44.9 1.0 CA C:CYS1402 4.7 41.6 1.0 C C:ARG1397 4.8 46.9 1.0 C C:CYS1402 4.9 45.8 1.0 N C:GLN1400 4.9 38.7 1.0 C C:ASP1399 4.9 43.1 1.0 CA C:ASP1403 4.9 42.9 1.0

Calcium binding site 2 out of 13 in the Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1702 b:50.6 occ:1.00 O C:ARG1484 2.1 57.9 1.0 OD2 C:ASP1500 2.2 74.5 1.0 OD1 C:ASP1482 2.3 52.5 1.0 OD2 C:ASP1497 2.3 68.8 1.0 OD2 C:ASP1486 2.5 69.4 1.0 O C:HIS1479 2.6 48.4 1.0 CG C:ASP1497 3.0 64.6 1.0 OD1 C:ASP1497 3.0 66.1 1.0 CG C:ASP1500 3.2 67.6 1.0 CG C:ASP1482 3.3 53.6 1.0 C C:ARG1484 3.4 58.5 1.0 CB C:ASP1500 3.6 56.7 1.0 CG C:ASP1486 3.6 63.7 1.0 C C:HIS1479 3.8 48.8 1.0 OD2 C:ASP1482 3.8 59.5 1.0 N C:ASP1486 3.9 53.8 1.0 O C:ASP1497 4.0 57.5 1.0 CB C:ASP1486 4.1 54.4 1.0 OD1 C:ASP1500 4.2 67.9 1.0 N C:ASP1482 4.3 47.2 1.0 N C:CYS1485 4.3 55.9 1.0 N C:ARG1484 4.3 54.3 1.0 CA C:CYS1485 4.3 56.0 1.0 CA C:ARG1484 4.3 54.1 1.0 CB C:ASP1497 4.4 55.2 1.0 C C:CYS1485 4.4 58.0 1.0 CB C:HIS1479 4.5 44.2 1.0 CB C:ASP1482 4.5 48.6 1.0 N C:ALA1481 4.6 46.1 1.0 CA C:ASP1486 4.7 52.9 1.0 CA C:HIS1479 4.7 43.8 1.0 OD1 C:ASP1486 4.7 64.6 1.0 N C:PHE1480 4.8 46.2 1.0 CA C:ASP1482 4.8 47.3 1.0 N C:GLY1483 4.9 51.4 1.0 CB C:ARG1484 4.9 53.7 1.0 C C:ASP1497 4.9 57.6 1.0 CA C:PHE1480 5.0 45.9 1.0 C C:PHE1480 5.0 49.0 1.0

Calcium binding site 3 out of 13 in the Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1703 b:69.2 occ:1.00 OD2 C:ASP1455 2.1 62.1 1.0 OD2 C:ASP1444 2.5 84.6 1.0 O C:ARG1442 2.5 70.3 1.0 OD1 C:ASN1440 2.6 57.7 1.0 O C:LEU1437 2.7 61.6 1.0 OD2 C:ASP1458 2.8 79.0 1.0 CG C:ASP1455 3.1 59.0 1.0 CG C:ASN1440 3.2 68.3 1.0 OD1 C:ASP1455 3.3 60.2 1.0 ND2 C:ASN1440 3.4 59.8 1.0 CG C:ASP1444 3.6 76.5 1.0 CG C:ASP1458 3.7 73.5 1.0 C C:ARG1442 3.7 71.0 1.0 C C:LEU1437 3.9 62.3 1.0 CB C:ASP1458 3.9 61.1 1.0 CB C:ASP1444 4.2 66.3 1.0 O C:ASP1455 4.2 53.2 1.0 N C:ASP1444 4.2 65.1 1.0 O C:ASN1440 4.3 69.5 1.0 N C:ARG1442 4.4 67.9 1.0 C C:ASN1440 4.4 69.6 1.0 CB C:ASP1455 4.4 50.8 1.0 CB C:ASN1440 4.5 59.8 1.0 CA C:ARG1442 4.6 67.8 1.0 CB C:LEU1437 4.6 57.9 1.0 OD1 C:ASP1444 4.6 76.1 1.0 N C:CYS1443 4.7 67.1 1.0 C C:SER1441 4.7 71.6 1.0 N C:PHE1438 4.7 59.3 1.0 CA C:ASN1440 4.7 63.0 1.0 N C:SER1441 4.8 67.4 1.0 N C:ASN1440 4.8 62.9 1.0 CA C:LEU1437 4.8 58.0 1.0 CA C:CYS1443 4.8 66.5 1.0 OD1 C:ASP1458 4.8 74.9 1.0 CA C:PHE1438 4.8 59.3 1.0 C C:CYS1443 4.8 69.5 1.0 CA C:ASP1444 4.9 64.6 1.0 CG C:ARG1442 4.9 77.9 1.0 O C:PHE1438 4.9 63.4 1.0 C C:ASP1455 5.0 54.1 1.0 C C:PHE1438 5.0 63.9 1.0

Calcium binding site 4 out of 13 in the Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment within 5.0Å range: probe atom residue distance (Å) B Occ F:Ca1701 b:53.9 occ:1.00 OD2 F:ASP1403 2.1 66.1 1.0 OD1 F:ASP1399 2.3 67.7 1.0 O F:LYS1396 2.3 71.2 1.0 OD2 F:ASP1414 2.5 76.1 1.0 O F:ARG1401 2.5 55.6 1.0 OD2 F:ASP1417 2.7 64.8 1.0 OD1 F:ASP1414 2.8 72.8 1.0 CG F:ASP1414 2.9 71.8 1.0 CG F:ASP1399 3.3 66.8 1.0 CG F:ASP1403 3.3 63.6 1.0 C F:LYS1396 3.4 71.3 1.0 C F:ARG1401 3.7 55.2 1.0 OD2 F:ASP1399 3.7 70.7 1.0 CG F:ASP1417 3.8 59.5 1.0 CB F:ASP1403 4.0 56.1 1.0 CB F:LYS1396 4.0 70.4 1.0 N F:ASP1403 4.1 54.5 1.0 CA F:LYS1396 4.1 68.6 1.0 CB F:ASP1417 4.2 53.6 1.0 N F:ASP1399 4.3 56.3 1.0 OD1 F:ASP1403 4.3 64.5 1.0 O F:ASP1414 4.3 60.6 1.0 CB F:ASP1414 4.3 61.3 1.0 N F:ARG1401 4.4 50.1 1.0 N F:ARG1397 4.4 66.4 1.0 CB F:ASP1399 4.4 57.0 1.0 CA F:ARG1401 4.5 49.8 1.0 N F:GLY1398 4.5 60.8 1.0 CA F:ARG1397 4.6 65.3 1.0 N F:CYS1402 4.7 51.9 1.0 CB F:ARG1401 4.7 48.9 1.0 CA F:ASP1403 4.7 54.7 1.0 CA F:CYS1402 4.8 51.7 1.0 CA F:ASP1399 4.8 55.3 1.0 C F:CYS1402 4.8 56.7 1.0 OD1 F:ASP1417 4.9 58.8 1.0 C F:ARG1397 4.9 66.5 1.0

Calcium binding site 5 out of 13 in the Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment within 5.0Å range: probe atom residue distance (Å) B Occ F:Ca1702 b:61.3 occ:1.00 OD2 F:ASP1444 2.3 66.6 1.0 O F:ARG1442 2.3 58.5 1.0 O F:LEU1437 2.3 61.8 1.0 OD1 F:ASN1440 2.3 66.6 1.0 OD2 F:ASP1458 2.6 56.5 1.0 OD2 F:ASP1455 2.6 56.7 1.0 OD1 F:ASP1455 2.6 56.2 1.0 CG F:ASP1455 2.9 55.3 1.0 CG F:ASN1440 3.3 75.7 1.0 CG F:ASP1444 3.5 63.5 1.0 C F:ARG1442 3.5 59.1 1.0 CG F:ASP1458 3.6 55.6 1.0 C F:LEU1437 3.6 62.0 1.0 ND2 F:ASN1440 3.7 68.3 1.0 CB F:ASP1458 3.8 50.0 1.0 N F:ARG1442 4.0 56.2 1.0 CB F:ASP1444 4.1 57.6 1.0 N F:ASP1444 4.1 57.1 1.0 CA F:ARG1442 4.3 55.8 1.0 O F:ASP1455 4.3 51.9 1.0 CB F:ASP1455 4.4 48.3 1.0 N F:PHE1438 4.4 58.2 1.0 OD1 F:ASP1444 4.5 64.1 1.0 O F:PHE1438 4.5 61.3 1.0 CB F:LEU1437 4.5 58.0 1.0 CA F:PHE1438 4.5 57.8 1.0 CA F:LEU1437 4.5 58.1 1.0 N F:CYS1443 4.5 55.6 1.0 C F:PHE1438 4.6 62.0 1.0 N F:SER1441 4.7 57.0 1.0 CB F:ASN1440 4.7 57.9 1.0 OD1 F:ASP1458 4.7 56.8 1.0 CA F:CYS1443 4.7 55.7 1.0 C F:CYS1443 4.7 60.5 1.0 CA F:ASP1444 4.8 56.3 1.0 N F:ASN1440 4.8 58.2 1.0 CB F:ARG1442 4.9 56.0 1.0 C F:ASP1455 4.9 51.5 1.0

Calcium binding site 6 out of 13 in the Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment within 5.0Å range: probe atom residue distance (Å) B Occ F:Ca1703 b:52.7 occ:1.00 OD1 F:ASP1482 2.3 59.8 1.0 O F:HIS1479 2.3 48.4 1.0 OD2 F:ASP1500 2.3 55.8 1.0 O F:ARG1484 2.4 46.6 1.0 OD2 F:ASP1497 2.4 58.6 1.0 OD2 F:ASP1486 2.5 56.9 1.0 OD1 F:ASP1497 2.9 51.3 1.0 CG F:ASP1497 3.0 52.0 1.0 CG F:ASP1482 3.3 60.1 1.0 CG F:ASP1500 3.3 52.0 1.0 C F:HIS1479 3.5 48.5 1.0 CG F:ASP1486 3.6 50.2 1.0 C F:ARG1484 3.6 48.3 1.0 OD2 F:ASP1482 3.7 67.7 1.0 CB F:ASP1500 3.8 44.5 1.0 O F:ASP1497 4.0 45.4 1.0 N F:ASP1486 4.0 42.2 1.0 CB F:ASP1486 4.1 43.1 1.0 CB F:HIS1479 4.2 45.0 1.0 N F:ASP1482 4.2 48.5 1.0 CA F:HIS1479 4.4 44.3 1.0 OD1 F:ASP1500 4.4 52.9 1.0 CB F:ASP1497 4.4 42.5 1.0 CB F:ASP1482 4.5 50.4 1.0 N F:ALA1481 4.5 46.1 1.0 N F:ARG1484 4.5 47.3 1.0 N F:CYS1485 4.5 45.1 1.0 N F:PHE1480 4.5 44.7 1.0 CA F:ARG1484 4.5 46.5 1.0 CA F:CYS1485 4.6 44.8 1.0 C F:CYS1485 4.6 47.1 1.0 OD1 F:ASP1486 4.7 49.4 1.0 CA F:ASP1486 4.7 41.6 1.0 CA F:PHE1480 4.7 44.4 1.0 C F:PHE1480 4.8 49.0 1.0 CA F:ASP1482 4.8 48.5 1.0 C F:ASP1497 4.9 45.5 1.0

Calcium binding site 7 out of 13 in the Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment within 5.0Å range: probe atom residue distance (Å) B Occ J:Ca1701 b:53.4 occ:1.00 OD2 J:ASP1414 2.2 85.6 1.0 O J:LYS1396 2.3 69.2 1.0 OD1 J:ASP1414 2.5 80.3 1.0 OD1 J:ASP1399 2.5 61.7 1.0 OD2 J:ASP1417 2.5 84.2 1.0 CG J:ASP1414 2.5 80.2 1.0 O J:ARG1401 2.5 62.8 1.0 OD1 J:ASP1403 2.6 76.8 1.0 C J:LYS1396 3.4 69.2 1.0 CG J:ASP1417 3.5 78.5 1.0 CG J:ASP1399 3.5 61.8 1.0 C J:ARG1401 3.7 63.4 1.0 CB J:ASP1417 3.8 69.1 1.0 CG J:ASP1403 3.8 76.5 1.0 CB J:ASP1414 3.9 72.2 1.0 O J:ASP1414 4.0 74.4 1.0 N J:ASP1399 4.1 55.9 1.0 OD2 J:ASP1399 4.1 66.9 1.0 N J:ASP1403 4.2 65.0 1.0 N J:GLY1398 4.2 60.5 1.0 CB J:LYS1396 4.3 68.3 1.0 CA J:LYS1396 4.3 66.0 1.0 N J:ARG1397 4.3 65.0 1.0 CB J:ASP1403 4.3 66.8 1.0 N J:ARG1401 4.4 55.9 1.0 CA J:ARG1397 4.5 64.2 1.0 CB J:ASP1399 4.6 56.2 1.0 CA J:ARG1401 4.6 56.1 1.0 C J:ARG1397 4.6 66.6 1.0 OD1 J:ASP1417 4.6 79.0 1.0 N J:CYS1402 4.7 62.9 1.0 CA J:CYS1402 4.7 64.0 1.0 CA J:ASP1399 4.8 54.9 1.0 OD2 J:ASP1403 4.8 82.0 1.0 C J:ASP1414 4.8 74.6 1.0 CA J:ASP1414 4.8 70.4 1.0 C J:CYS1402 4.9 68.3 1.0 N J:GLN1400 4.9 53.7 1.0 CA J:ASP1403 4.9 64.8 1.0 CB J:ARG1401 4.9 54.1 1.0 CA J:GLY1398 4.9 59.0 1.0

Calcium binding site 8 out of 13 in the Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 8 of Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment within 5.0Å range: probe atom residue distance (Å) B Occ J:Ca1702 b:48.5 occ:1.00 OD2 J:ASP1497 2.1 54.5 1.0 O J:HIS1479 2.3 46.2 1.0 OD2 J:ASP1500 2.4 60.1 1.0 OD2 J:ASP1486 2.5 62.5 1.0 O J:ARG1484 2.5 42.2 1.0 OD1 J:ASP1497 2.6 49.1 1.0 OD1 J:ASP1482 2.6 57.5 1.0 CG J:ASP1497 2.6 50.1 1.0 CG J:ASP1500 3.4 55.7 1.0 C J:HIS1479 3.5 46.7 1.0 CG J:ASP1486 3.5 55.3 1.0 CG J:ASP1482 3.6 55.5 1.0 C J:ARG1484 3.8 43.8 1.0 CB J:ASP1500 3.8 47.6 1.0 O J:ASP1497 3.8 47.2 1.0 CB J:ASP1486 3.9 42.8 1.0 N J:ASP1486 3.9 40.9 1.0 OD2 J:ASP1482 4.0 62.1 1.0 CB J:ASP1497 4.1 45.5 1.0 CB J:HIS1479 4.2 45.0 1.0 CA J:HIS1479 4.4 44.4 1.0 N J:ASP1482 4.4 38.6 1.0 N J:PHE1480 4.4 41.8 1.0 N J:ALA1481 4.5 36.7 1.0 OD1 J:ASP1500 4.5 56.4 1.0 CA J:ASP1486 4.5 40.7 1.0 C J:CYS1485 4.6 45.1 1.0 CA J:CYS1485 4.6 42.6 1.0 CA J:PHE1480 4.6 40.2 1.0 N J:CYS1485 4.6 42.1 1.0 OD1 J:ASP1486 4.6 56.2 1.0 C J:ASP1497 4.6 47.3 1.0 CB J:ASP1482 4.7 40.6 1.0 N J:ARG1484 4.8 38.5 1.0 C J:PHE1480 4.8 41.6 1.0 CA J:ARG1484 4.8 38.6 1.0 CA J:ASP1497 4.8 44.0 1.0

Calcium binding site 9 out of 13 in the Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 9 of Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment within 5.0Å range: probe atom residue distance (Å) B Occ J:Ca1703 b:122.6 occ:1.00 O J:LEU1437 2.2 97.9 1.0 OD1 J:ASN1440 2.3 118.1 1.0 OD2 J:ASP1455 2.5 91.4 1.0 ND2 J:ASN1440 2.8 113.2 1.0 CG J:ASN1440 2.9 121.8 1.0 OD2 J:ASP1444 2.9 106.3 1.0 O J:ARG1442 3.0 100.4 1.0 OD2 J:ASP1458 3.0 96.0 1.0 OD1 J:ASP1455 3.1 85.2 1.0 CG J:ASP1455 3.2 85.1 1.0 C J:LEU1437 3.3 98.1 1.0 CG J:ASP1444 3.7 101.5 1.0 CB J:ASP1444 3.9 95.4 1.0 CA J:LEU1437 4.0 94.2 1.0 CG J:ASP1458 4.1 90.1 1.0 C J:ARG1442 4.1 100.6 1.0 CB J:LEU1437 4.1 94.2 1.0 N J:ASP1444 4.3 94.7 1.0 CB J:ASP1458 4.4 80.6 1.0 CB J:ASN1440 4.4 95.7 1.0 N J:PHE1438 4.4 94.3 1.0 C J:CYS1443 4.6 99.2 1.0 CB J:ASP1455 4.6 75.4 1.0 CG J:LEU1437 4.7 98.9 1.0 OD1 J:ASP1444 4.7 101.1 1.0 CA J:PHE1438 4.7 93.9 1.0 O J:ASP1455 4.7 78.2 1.0 N J:ARG1442 4.7 96.3 1.0 CA J:ASP1444 4.8 93.9 1.0 CA J:CYS1443 4.8 97.0 1.0 N J:CYS1443 4.8 97.3 1.0

Calcium binding site 10 out of 13 in the Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 10 of Structure of the NOTCH3 Nrr in Complex with An Antibody Fab Fragment within 5.0Å range: probe atom residue distance (Å) B Occ X:Ca1701 b:39.5 occ:1.00 OD2 X:ASP1414 2.1 60.2 1.0 O X:LYS1396 2.3 38.1 1.0 OD1 X:ASP1399 2.3 42.9 1.0 O X:ARG1401 2.4 38.4 1.0 OD2 X:ASP1403 2.4 51.1 1.0 CG X:ASP1414 2.6 58.1 1.0 OD1 X:ASP1414 2.7 60.4 1.0 OD2 X:ASP1417 2.7 55.8 1.0 CG X:ASP1399 3.4 42.4 1.0 C X:LYS1396 3.4 38.6 1.0 CG X:ASP1403 3.6 48.0 1.0 C X:ARG1401 3.6 39.9 1.0 CG X:ASP1417 3.7 48.9 1.0 CB X:ASP1417 3.8 43.3 1.0 O X:ASP1414 3.9 50.5 1.0 OD2 X:ASP1399 4.0 48.1 1.0 CB X:ASP1414 4.0 49.8 1.0 N X:ASP1399 4.1 32.5 1.0 N X:ASP1403 4.1 42.9 1.0 CB X:LYS1396 4.2 35.4 1.0 CA X:LYS1396 4.2 34.9 1.0 CB X:ASP1403 4.3 43.6 1.0 N X:ARG1401 4.3 35.3 1.0 CB X:ASP1399 4.4 33.7 1.0 N X:ARG1397 4.4 34.9 1.0 N X:GLY1398 4.4 32.9 1.0 CA X:ARG1401 4.4 35.0 1.0 OD1 X:ASP1403 4.6 48.6 1.0 N X:CYS1402 4.6 38.7 1.0 CA X:ARG1397 4.6 34.7 1.0 CA X:ASP1399 4.6 32.4 1.0 CA X:CYS1402 4.6 39.6 1.0 CB X:ARG1401 4.7 32.1 1.0 C X:ASP1414 4.8 50.0 1.0 C X:ARG1397 4.8 37.4 1.0 C X:CYS1402 4.8 45.3 1.0 OD1 X:ASP1417 4.8 47.5 1.0 CA X:ASP1414 4.9 48.0 1.0 CA X:ASP1403 4.9 42.5 1.0 C X:ASP1399 4.9 37.4 1.0 N X:GLN1400 4.9 34.2 1.0

K.G.Geles, Y.Gao, A.Giannakou, J.Pignatelli, L.Sridharan, T.Yamin, J.Zhang, R.Karim, J.Bard, M.Charati, A.Maderna, J.Lucas, J.Golas, M.Guffroy, S.Pirie-Shepherd, M.Roy, J.Qian, T.Franks, W.Zhong, C.O'donnell, L.Tchistiakova, H.P.Gerber, P.Sapra. Therapeutic Targeting Oncogenic NOTCH3 Pathway with A Non-Signaling Inhibitory Antibody Drug Conjugate To Be Published.