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Calcium in PDB 6ye2: Human Ecto-5'-Nucleotidase (CD73) in Complex with the Ampcp Derivative A1202 (Compound 4A in Publication) in the Closed Form (Crystal Form IV)Enzymatic activity of Human Ecto-5'-Nucleotidase (CD73) in Complex with the Ampcp Derivative A1202 (Compound 4A in Publication) in the Closed Form (Crystal Form IV)
All present enzymatic activity of Human Ecto-5'-Nucleotidase (CD73) in Complex with the Ampcp Derivative A1202 (Compound 4A in Publication) in the Closed Form (Crystal Form IV):
3.1.3.5; Protein crystallography data
The structure of Human Ecto-5'-Nucleotidase (CD73) in Complex with the Ampcp Derivative A1202 (Compound 4A in Publication) in the Closed Form (Crystal Form IV), PDB code: 6ye2
was solved by
E.Scaletti,
N.Strater,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6ye2:
The structure of Human Ecto-5'-Nucleotidase (CD73) in Complex with the Ampcp Derivative A1202 (Compound 4A in Publication) in the Closed Form (Crystal Form IV) also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the Human Ecto-5'-Nucleotidase (CD73) in Complex with the Ampcp Derivative A1202 (Compound 4A in Publication) in the Closed Form (Crystal Form IV)
(pdb code 6ye2). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Human Ecto-5'-Nucleotidase (CD73) in Complex with the Ampcp Derivative A1202 (Compound 4A in Publication) in the Closed Form (Crystal Form IV), PDB code: 6ye2: Jump to Calcium binding site number: 1; 2; Calcium binding site 1 out of 2 in 6ye2Go back to Calcium Binding Sites List in 6ye2
Calcium binding site 1 out
of 2 in the Human Ecto-5'-Nucleotidase (CD73) in Complex with the Ampcp Derivative A1202 (Compound 4A in Publication) in the Closed Form (Crystal Form IV)
Mono view Stereo pair view
Calcium binding site 2 out of 2 in 6ye2Go back to Calcium Binding Sites List in 6ye2
Calcium binding site 2 out
of 2 in the Human Ecto-5'-Nucleotidase (CD73) in Complex with the Ampcp Derivative A1202 (Compound 4A in Publication) in the Closed Form (Crystal Form IV)
Mono view Stereo pair view
Reference:
E.U.Sharif,
J.Kalisiak,
K.V.Lawson,
D.H.Miles,
E.Newcomb,
E.A.Lindsey,
B.R.Rosen,
L.P.P.Debien,
A.Chen,
X.Zhao,
S.W.Young,
N.P.Walker,
N.Strater,
E.R.Scaletti,
L.Jin,
G.Xu,
M.R.Leleti,
J.P.Powers.
Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors. J.Med.Chem. 2021.
Page generated: Sun Jan 24 09:36:09 2021
ISSN: ISSN 0022-2623 PubMed: 33399453 DOI: 10.1021/ACS.JMEDCHEM.0C01835 |
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