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Calcium in PDB 7ahv: Anti-Fixa Fab of MIM8 in Complex with Human Fixa

Enzymatic activity of Anti-Fixa Fab of MIM8 in Complex with Human Fixa

All present enzymatic activity of Anti-Fixa Fab of MIM8 in Complex with Human Fixa:
3.4.21.22;

Protein crystallography data

The structure of Anti-Fixa Fab of MIM8 in Complex with Human Fixa, PDB code: 7ahv was solved by E.Johansson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.52 / 3.11
Space group P 41 2 2
Cell size a, b, c (Å), α, β, γ (°) 97.03, 97.03, 254.51, 90, 90, 90
R / Rfree (%) 22.7 / 28.4

Calcium Binding Sites:

The binding sites of Calcium atom in the Anti-Fixa Fab of MIM8 in Complex with Human Fixa (pdb code 7ahv). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Anti-Fixa Fab of MIM8 in Complex with Human Fixa, PDB code: 7ahv:

Calcium binding site 1 out of 1 in 7ahv

Go back to Calcium Binding Sites List in 7ahv
Calcium binding site 1 out of 1 in the Anti-Fixa Fab of MIM8 in Complex with Human Fixa


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Anti-Fixa Fab of MIM8 in Complex with Human Fixa within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Ca509

b:73.7
occ:1.00
OE1 H:GLU77 2.2 49.9 1.0
O H:ASN72 2.4 48.5 1.0
OE1 H:GLU70 2.7 51.4 1.0
O H:GLU75 2.8 41.9 1.0
CD H:GLU77 3.0 46.3 1.0
C H:ASN72 3.3 41.6 1.0
OE2 H:GLU80 3.4 38.3 1.0
CG H:GLU77 3.4 43.4 1.0
N H:ASN72 3.7 41.1 1.0
CB H:GLU77 3.8 31.8 1.0
CD H:GLU70 3.9 46.6 1.0
N H:HIS71 3.9 35.4 1.0
N H:GLU77 4.0 34.8 1.0
OE2 H:GLU77 4.0 37.3 1.0
C H:GLU75 4.0 41.1 1.0
CA H:ASN72 4.0 36.4 1.0
N H:ILE73 4.2 38.2 1.0
CD H:GLU80 4.3 41.4 1.0
CA H:ILE73 4.4 34.9 1.0
CG H:GLU80 4.5 33.8 1.0
CA H:GLU77 4.5 31.5 1.0
CB H:ASN72 4.5 40.3 1.0
C H:HIS71 4.5 44.9 1.0
N H:GLU75 4.6 51.8 1.0
CG H:GLU70 4.6 40.9 1.0
C H:THR76 4.7 34.4 1.0
CA H:HIS71 4.7 38.6 1.0
CA H:GLU70 4.7 35.8 1.0
CA H:GLU75 4.8 45.4 1.0
OE2 H:GLU70 4.8 40.6 1.0
CA H:THR76 4.8 33.1 1.0
C H:GLU70 4.8 39.4 1.0
C H:ILE73 4.9 36.2 1.0
N H:THR76 4.9 42.3 1.0

Reference:

H.Ostergaard, J.Lund, P.J.Greisen, S.Kjellev, A.Henriksen, N.Lorenzen, E.Johansson, G.Roder, M.G.Rasch, L.B.Johnsen, T.Egebjerg, S.Lund, H.Rahbek-Nielsen, P.S.Gandhi, K.Lamberth, M.Loftager, L.M.Andersen, A.C.Bonde, F.Stavenuiter, D.E.Madsen, X.Li, T.L.Holm, C.D.Ley, P.Thygesen, H.Zhu, R.Zhou, K.Thorn, Z.Yang, M.B.Hermit, J.R.Bjelke, B.G.Hansen, I.Hilden. Fviiia-Mimetic Bispecific Antibody (MIM8) Ameliorates Bleeding Upon Severe Vascular Challenge in Hemophilia A Mice. Blood 2021.
ISSN: ESSN 1528-0020
PubMed: 34077951
DOI: 10.1182/BLOOD.2020010331
Page generated: Sat Jul 10 11:14:07 2021

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