Calcium in PDB 7ayf: 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound TCF521- 110

Enzymatic activity of 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound TCF521- 110

All present enzymatic activity of 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound TCF521- 110:
5.2.1.8;

Protein crystallography data

The structure of 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound TCF521- 110, PDB code: 7ayf was solved by M.Wolter, L.V.Dijck, C.Ottmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 33.16 / 1.75
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 82.312, 112.002, 62.673, 90, 90, 90
R / Rfree (%) 17.4 / 21.7

Other elements in 7ayf:

The structure of 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound TCF521- 110 also contains other interesting chemical elements:

Bromine (Br) 1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound TCF521- 110 (pdb code 7ayf). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound TCF521- 110, PDB code: 7ayf:

Calcium binding site 1 out of 1 in 7ayf

Go back to Calcium Binding Sites List in 7ayf
Calcium binding site 1 out of 1 in the 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound TCF521- 110


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound TCF521- 110 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca302

b:15.5
occ:0.88
 O A:GLU110 2.3 11.2 1.0
O A:HOH527 2.3 25.4 1.0
OE1 A:GLU35 2.4 13.7 1.0
O A:HOH637 2.4 21.0 1.0
OE2 A:GLU35 2.7 21.0 1.0
CD A:GLU35 2.9 23.2 1.0
C A:GLU110 3.5 10.5 1.0
N A:GLY112 4.0 12.7 1.0
O A:HOH648 4.1 33.9 1.0
CG A:GLU35 4.3 10.5 1.0
CA A:GLU110 4.4 5.8 1.0
N A:ALA111 4.4 9.0 1.0
CA A:ALA111 4.5 7.9 1.0
CB A:GLU110 4.6 10.1 1.0
O A:HOH496 4.6 20.7 1.0
OE1 A:GLU110 4.6 25.9 1.0
O A:HOH635 4.6 23.8 1.0
C A:ALA111 4.7 8.5 1.0
CA A:GLY112 4.7 14.6 1.0
O A:HOH494 4.8 26.3 1.0
O A:HOH587 5.0 18.3 1.0

Reference:

P.J.Cossar, M.Wolter, L.Van Dijck, D.Valenti, L.M.Levy, C.Ottmann, L.Brunsveld. Reversible Covalent Imine-Tethering For Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc. 2021.
ISSN: ESSN 1520-5126
PubMed: 34047554
DOI: 10.1021/JACS.1C03035
Page generated: Sat Jul 10 11:14:06 2021

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