Calcium in PDB 7b05: TRPC4 in Complex with Inhibitor Gfb-8749

The structure of TRPC4 in Complex with Inhibitor Gfb-8749 also contains other interesting chemical elements:

Fluorine	(F)	8 atoms
Chlorine	(Cl)	4 atoms

The binding sites of Calcium atom in the TRPC4 in Complex with Inhibitor Gfb-8749 (pdb code 7b05). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the TRPC4 in Complex with Inhibitor Gfb-8749, PDB code: 7b05:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1002 b:92.7 occ:1.00 OD1 A:ASN435 2.5 92.4 1.0 OE1 A:GLN420 2.6 0.3 1.0 OE1 A:GLU417 2.7 0.5 1.0 OD1 A:ASP438 3.0 83.8 1.0 CG A:ASN435 3.7 92.4 1.0 CD A:GLN420 3.7 0.3 1.0 CD A:GLU417 3.7 0.5 1.0 OE2 A:GLU417 3.9 0.5 1.0 CG A:ASP438 4.2 83.8 1.0 NE2 A:GLN420 4.2 0.3 1.0 CA A:ASN435 4.4 92.4 1.0 CB A:ASN435 4.5 92.4 1.0 NH1 A:ARG491 4.6 62.4 1.0 ND2 A:ASN435 4.6 92.4 1.0 CB A:ASP438 4.8 83.8 1.0 CG A:GLN420 4.9 0.3 1.0 CE1 A:TYR429 4.9 0.4 1.0 N A:ASN435 4.9 92.4 1.0

Calcium binding site 2 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1002 b:90.6 occ:1.00 OD1 B:ASN435 2.5 92.5 1.0 OE1 B:GLN420 2.6 0.0 1.0 OE1 B:GLU417 2.7 1.0 1.0 OD1 B:ASP438 3.0 83.5 1.0 CG B:ASN435 3.7 92.5 1.0 CD B:GLN420 3.7 0.0 1.0 CD B:GLU417 3.7 1.0 1.0 OE2 B:GLU417 3.9 1.0 1.0 CG B:ASP438 4.2 83.5 1.0 NE2 B:GLN420 4.2 0.0 1.0 CA B:ASN435 4.4 92.5 1.0 CB B:ASN435 4.5 92.5 1.0 NH1 B:ARG491 4.6 62.2 1.0 ND2 B:ASN435 4.6 92.5 1.0 CB B:ASP438 4.8 83.5 1.0 CG B:GLN420 4.9 0.0 1.0 CE1 B:TYR429 4.9 1.0 1.0 N B:ASN435 4.9 92.5 1.0

Calcium binding site 3 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1002 b:91.8 occ:1.00 OD1 C:ASN435 2.5 92.4 1.0 OE1 C:GLN420 2.6 0.9 1.0 OE1 C:GLU417 2.7 0.3 1.0 OD1 C:ASP438 3.0 83.5 1.0 CG C:ASN435 3.7 92.4 1.0 CD C:GLN420 3.7 0.9 1.0 CD C:GLU417 3.7 0.3 1.0 OE2 C:GLU417 3.9 0.3 1.0 CG C:ASP438 4.2 83.5 1.0 NE2 C:GLN420 4.2 0.9 1.0 CA C:ASN435 4.4 92.4 1.0 CB C:ASN435 4.5 92.4 1.0 NH1 C:ARG491 4.6 61.7 1.0 ND2 C:ASN435 4.6 92.4 1.0 CB C:ASP438 4.8 83.5 1.0 CG C:GLN420 4.9 0.9 1.0 CE1 C:TYR429 4.9 0.3 1.0 N C:ASN435 4.9 92.4 1.0

Calcium binding site 4 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1002 b:92.7 occ:1.00 OD1 D:ASN435 2.5 92.7 1.0 OE1 D:GLN420 2.6 0.1 1.0 OE1 D:GLU417 2.7 0.4 1.0 OD1 D:ASP438 3.0 83.6 1.0 CG D:ASN435 3.7 92.7 1.0 CD D:GLN420 3.7 0.1 1.0 CD D:GLU417 3.7 0.4 1.0 OE2 D:GLU417 3.9 0.4 1.0 CG D:ASP438 4.2 83.6 1.0 NE2 D:GLN420 4.2 0.1 1.0 CA D:ASN435 4.4 92.7 1.0 CB D:ASN435 4.5 92.7 1.0 NH1 D:ARG491 4.6 61.9 1.0 ND2 D:ASN435 4.6 92.7 1.0 CB D:ASP438 4.8 83.6 1.0 CG D:GLN420 4.9 0.1 1.0 CE1 D:TYR429 4.9 0.0 1.0 N D:ASN435 4.9 92.7 1.0

D.Vinayagam, D.Quentin, J.Yu-Strzelczyk, O.Sitsel, F.Merino, M.Stabrin, O.Hofnagel, M.Yu, M.W.Ledeboer, G.Nagel, G.Malojcic, S.Raunser. Structural Basis of TRPC4 Regulation By Calmodulin and Pharmacological Agents. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 33236980
DOI: 10.7554/ELIFE.60603