Calcium in PDB 7b0s: TRPC4 in Complex with Inhibitor Gfb-8438

The structure of TRPC4 in Complex with Inhibitor Gfb-8438 also contains other interesting chemical elements:

Fluorine	(F)	12 atoms
Chlorine	(Cl)	4 atoms

The binding sites of Calcium atom in the TRPC4 in Complex with Inhibitor Gfb-8438 (pdb code 7b0s). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the TRPC4 in Complex with Inhibitor Gfb-8438, PDB code: 7b0s:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1002 b:72.6 occ:1.00 OE1 A:GLN420 2.9 97.7 1.0 OD2 A:ASP438 3.1 73.4 1.0 OD1 A:ASN435 3.6 76.8 1.0 CD A:GLN420 3.7 97.7 1.0 OE1 A:GLU417 3.7 91.8 1.0 NE2 A:GLN420 3.7 97.7 1.0 CG A:ASN435 3.8 76.8 1.0 ND2 A:ASN435 4.2 76.8 1.0 O1 A:S9Q1001 4.2 70.1 1.0 CG A:ASP438 4.3 73.4 1.0 CB A:ASN435 4.3 76.8 1.0 CA A:ASN435 4.6 76.8 1.0 CD A:GLU417 4.6 91.8 1.0 OE2 A:GLU417 4.7 91.8 1.0 CB A:ASP438 4.8 73.4 1.0 NH2 A:ARG491 4.8 51.4 1.0

Calcium binding site 2 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1002 b:72.8 occ:1.00 OD2 B:ASP438 3.1 73.5 1.0 OE1 B:GLN420 3.6 98.1 1.0 OD1 B:ASN435 3.6 76.4 1.0 NE2 B:GLN420 3.7 98.1 1.0 OE1 B:GLU417 3.7 92.1 1.0 CG B:ASN435 3.8 76.4 1.0 CD B:GLN420 3.8 98.1 1.0 ND2 B:ASN435 4.2 76.4 1.0 O1 B:S9Q1001 4.2 70.5 1.0 CG B:ASP438 4.3 73.5 1.0 CB B:ASN435 4.3 76.4 1.0 CA B:ASN435 4.6 76.4 1.0 CD B:GLU417 4.6 92.1 1.0 OE2 B:GLU417 4.7 92.1 1.0 CB B:ASP438 4.8 73.5 1.0 NH2 B:ARG491 4.8 51.4 1.0 CG B:GLN420 4.9 98.1 1.0

Calcium binding site 3 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1002 b:74.1 occ:1.00 OE1 C:GLN420 2.9 97.2 1.0 OD2 C:ASP438 3.1 73.2 1.0 OD1 C:ASN435 3.6 76.8 1.0 OE1 C:GLU417 3.7 91.5 1.0 CD C:GLN420 3.8 97.2 1.0 CG C:ASN435 3.8 76.8 1.0 NE2 C:GLN420 4.0 97.2 1.0 ND2 C:ASN435 4.2 76.8 1.0 O1 C:S9Q1001 4.2 70.4 1.0 CG C:ASP438 4.3 73.2 1.0 CB C:ASN435 4.3 76.8 1.0 CA C:ASN435 4.6 76.8 1.0 CD C:GLU417 4.6 91.5 1.0 OE2 C:GLU417 4.7 91.5 1.0 CB C:ASP438 4.8 73.2 1.0 NH2 C:ARG491 4.8 51.5 1.0

Calcium binding site 4 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1002 b:73.4 occ:1.00 OE1 D:GLN420 2.9 97.5 1.0 OD2 D:ASP438 3.1 73.3 1.0 OD1 D:ASN435 3.6 76.5 1.0 CD D:GLN420 3.7 97.5 1.0 OE1 D:GLU417 3.7 91.8 1.0 NE2 D:GLN420 3.8 97.5 1.0 CG D:ASN435 3.8 76.5 1.0 ND2 D:ASN435 4.2 76.5 1.0 O1 D:S9Q1001 4.2 70.2 1.0 CG D:ASP438 4.3 73.3 1.0 CB D:ASN435 4.3 76.5 1.0 CA D:ASN435 4.6 76.5 1.0 CD D:GLU417 4.6 91.8 1.0 OE2 D:GLU417 4.7 91.8 1.0 CB D:ASP438 4.8 73.3 1.0 NH2 D:ARG491 4.8 51.2 1.0

D.Vinayagam, D.Quentin, J.Yu-Strzelczyk, O.Sitsel, F.Merino, M.Stabrin, O.Hofnagel, M.Yu, M.W.Ledeboer, G.Nagel, G.Malojcic, S.Raunser. Structural Basis of TRPC4 Regulation By Calmodulin and Pharmacological Agents. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 33236980
DOI: 10.7554/ELIFE.60603