Calcium in PDB 7b16: TRPC4 in Complex with Inhibitor Gfb-9289

The structure of TRPC4 in Complex with Inhibitor Gfb-9289 also contains other interesting chemical elements:

Chlorine

(Cl)

4 atoms

The binding sites of Calcium atom in the TRPC4 in Complex with Inhibitor Gfb-9289 (pdb code 7b16). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the TRPC4 in Complex with Inhibitor Gfb-9289, PDB code: 7b16:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-9289


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of TRPC4 in Complex with Inhibitor Gfb-9289 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1002 b:44.8 occ:1.00 OD1 A:ASN435 2.5 51.5 1.0 OE1 A:GLU417 2.5 61.2 1.0 OD2 A:ASP438 2.6 39.2 1.0 CD A:GLU417 3.3 61.2 1.0 OE2 A:GLU417 3.4 61.2 1.0 OE1 A:GLN420 3.5 68.8 1.0 CG A:ASN435 3.6 51.5 1.0 CG A:ASP438 3.7 39.2 1.0 NH2 A:ARG491 3.8 26.7 1.0 CB A:ASP438 4.2 39.2 1.0 CA A:ASN435 4.2 51.5 1.0 CB A:ASN435 4.4 51.5 1.0 CD A:GLN420 4.6 68.8 1.0 ND2 A:ASN435 4.6 51.5 1.0 C03 A:SKQ1001 4.7 32.1 1.0 OD1 A:ASP438 4.7 39.2 1.0 CG A:GLU417 4.7 61.2 1.0 N A:ASN435 4.8 51.5 1.0 O01 A:SKQ1001 4.8 32.1 1.0 CZ A:ARG491 4.9 26.7 1.0 O A:TRP434 5.0 39.4 1.0 OH A:TYR429 5.0 73.7 1.0 CE1 A:TYR429 5.0 73.7 1.0

Calcium binding site 2 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-9289


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of TRPC4 in Complex with Inhibitor Gfb-9289 within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1003 b:45.4 occ:1.00 OD1 B:ASN435 2.5 51.9 1.0 OE1 B:GLU417 2.5 61.2 1.0 OD2 B:ASP438 2.6 39.5 1.0 CD B:GLU417 3.3 61.2 1.0 OE2 B:GLU417 3.4 61.2 1.0 CG B:ASN435 3.6 51.9 1.0 OE1 B:GLN420 3.7 68.8 1.0 CG B:ASP438 3.7 39.5 1.0 NH2 B:ARG491 3.8 26.9 1.0 CB B:ASP438 4.2 39.5 1.0 CA B:ASN435 4.2 51.9 1.0 CD B:GLN420 4.4 68.8 1.0 CB B:ASN435 4.4 51.9 1.0 NE2 B:GLN420 4.4 68.8 1.0 ND2 B:ASN435 4.6 51.9 1.0 C03 B:SKQ1002 4.7 32.5 1.0 OD1 B:ASP438 4.7 39.5 1.0 CG B:GLU417 4.7 61.2 1.0 N B:ASN435 4.8 51.9 1.0 O01 B:SKQ1002 4.8 32.5 1.0 CZ B:ARG491 4.9 26.9 1.0 O B:TRP434 5.0 39.4 1.0 OH B:TYR429 5.0 73.9 1.0 CE1 B:TYR429 5.0 73.9 1.0

Calcium binding site 3 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-9289


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of TRPC4 in Complex with Inhibitor Gfb-9289 within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1003 b:45.3 occ:1.00 OD1 C:ASN435 2.5 52.0 1.0 OE1 C:GLU417 2.5 61.2 1.0 OD2 C:ASP438 2.6 39.6 1.0 CD C:GLU417 3.3 61.2 1.0 OE2 C:GLU417 3.4 61.2 1.0 OE1 C:GLN420 3.4 68.6 1.0 CG C:ASN435 3.6 52.0 1.0 CG C:ASP438 3.7 39.6 1.0 NH2 C:ARG491 3.8 26.9 1.0 CB C:ASP438 4.2 39.6 1.0 CA C:ASN435 4.2 52.0 1.0 CB C:ASN435 4.4 52.0 1.0 CD C:GLN420 4.6 68.6 1.0 ND2 C:ASN435 4.6 52.0 1.0 C03 C:SKQ1002 4.7 32.7 1.0 OD1 C:ASP438 4.7 39.6 1.0 CG C:GLU417 4.7 61.2 1.0 N C:ASN435 4.8 52.0 1.0 O01 C:SKQ1002 4.8 32.7 1.0 CZ C:ARG491 4.9 26.9 1.0 O C:TRP434 5.0 39.6 1.0 OH C:TYR429 5.0 74.1 1.0 CE1 C:TYR429 5.0 74.1 1.0

Calcium binding site 4 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-9289


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of TRPC4 in Complex with Inhibitor Gfb-9289 within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1003 b:45.2 occ:1.00 OD1 D:ASN435 2.5 51.8 1.0 OE1 D:GLU417 2.5 60.7 1.0 OD2 D:ASP438 2.6 39.3 1.0 CD D:GLU417 3.3 60.7 1.0 OE2 D:GLU417 3.4 60.7 1.0 OE1 D:GLN420 3.4 68.2 1.0 CG D:ASN435 3.6 51.8 1.0 CG D:ASP438 3.7 39.3 1.0 NH2 D:ARG491 3.8 26.7 1.0 CB D:ASP438 4.2 39.3 1.0 CA D:ASN435 4.2 51.8 1.0 CB D:ASN435 4.4 51.8 1.0 CD D:GLN420 4.6 68.2 1.0 ND2 D:ASN435 4.6 51.8 1.0 C03 D:SKQ1002 4.7 32.2 1.0 OD1 D:ASP438 4.7 39.3 1.0 CG D:GLU417 4.7 60.7 1.0 N D:ASN435 4.8 51.8 1.0 O01 D:SKQ1002 4.8 32.2 1.0 CZ D:ARG491 4.9 26.7 1.0 O D:TRP434 5.0 39.5 1.0 OH D:TYR429 5.0 73.9 1.0 CE1 D:TYR429 5.0 73.9 1.0

D.Vinayagam, D.Quentin, J.Yu-Strzelczyk, O.Sitsel, F.Merino, M.Stabrin, O.Hofnagel, M.Yu, M.W.Ledeboer, G.Nagel, G.Malojcic, S.Raunser. Structural Basis of TRPC4 Regulation By Calmodulin and Pharmacological Agents. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 33236980
DOI: 10.7554/ELIFE.60603