Calcium in PDB 7dd5: Structure of Calcium-Sensing Receptor in Complex with Nps-2143

The structure of Structure of Calcium-Sensing Receptor in Complex with Nps-2143 also contains other interesting chemical elements:

Chlorine

(Cl)

4 atoms

The binding sites of Calcium atom in the Structure of Calcium-Sensing Receptor in Complex with Nps-2143 (pdb code 7dd5). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 6 binding sites of Calcium where determined in the Structure of Calcium-Sensing Receptor in Complex with Nps-2143, PDB code: 7dd5:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6;

Calcium binding site 1 out of 6 in the Structure of Calcium-Sensing Receptor in Complex with Nps-2143


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Calcium-Sensing Receptor in Complex with Nps-2143 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1102 b:183.0 occ:1.00 O A:HOH1201 3.1 142.6 1.0 OD1 A:ASP234 3.4 147.0 1.0 O B:GLY556 4.1 164.1 1.0 O A:GLU232 4.2 148.8 1.0 CG A:ASP234 4.2 147.0 1.0 OD2 A:ASP234 4.3 147.0 1.0 O A:GLU231 4.7 152.9 1.0 C B:GLY556 4.8 164.1 1.0

Calcium binding site 2 out of 6 in the Structure of Calcium-Sensing Receptor in Complex with Nps-2143


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Calcium-Sensing Receptor in Complex with Nps-2143 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1103 b:186.7 occ:1.00 OG A:SER302 2.5 140.6 1.0 CB A:SER302 3.2 140.6 1.0 CA A:SER302 3.5 140.6 1.0 CH2 A:TRP1108 4.0 133.4 1.0 N A:SER303 4.1 143.8 1.0 NH1 A:ARG66 4.1 130.3 1.0 C A:SER302 4.3 140.6 1.0 CZ A:PHE42 4.6 140.2 1.0 CE1 A:PHE42 4.7 140.2 1.0 N A:SER302 4.7 140.6 1.0 OG A:SER303 4.7 143.8 1.0 CD A:ARG66 4.8 130.3 1.0 CZ3 A:TRP1108 4.8 133.4 1.0 CZ2 A:TRP1108 4.8 133.4 1.0 N A:LEU304 4.9 144.0 1.0

Calcium binding site 3 out of 6 in the Structure of Calcium-Sensing Receptor in Complex with Nps-2143


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structure of Calcium-Sensing Receptor in Complex with Nps-2143 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1104 b:182.8 occ:1.00 OG1 A:THR100 2.4 146.6 1.0 O A:ALA144 2.5 136.4 1.0 CG2 A:THR145 2.8 135.1 1.0 CB A:THR100 3.1 146.6 1.0 CG2 A:THR100 3.4 146.6 1.0 C A:ALA144 3.6 136.4 1.0 CG1 A:VAL149 3.7 123.8 1.0 CB A:THR145 4.1 135.1 1.0 CB A:VAL149 4.2 123.8 1.0 CG2 A:VAL149 4.3 123.8 1.0 CA A:ALA144 4.4 136.4 1.0 CA A:THR100 4.5 146.6 1.0 CA A:ASN102 4.5 140.9 1.0 N A:THR145 4.5 135.1 1.0 N A:PRO39 4.5 132.7 1.0 CB A:PRO39 4.6 132.7 1.0 N A:ASN102 4.6 140.9 1.0 C A:PHE38 4.6 132.0 1.0 CD A:PRO39 4.7 132.7 1.0 CA A:THR145 4.7 135.1 1.0 N A:GLY146 4.7 127.9 1.0 CA A:PRO39 4.8 132.7 1.0 CB A:ALA144 4.9 136.4 1.0 C A:THR145 4.9 135.1 1.0 O A:PHE38 4.9 132.0 1.0 C A:THR100 4.9 146.6 1.0 N A:PHE38 5.0 132.0 1.0

Calcium binding site 4 out of 6 in the Structure of Calcium-Sensing Receptor in Complex with Nps-2143


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structure of Calcium-Sensing Receptor in Complex with Nps-2143 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1110 b:179.3 occ:1.00 OD1 B:ASP234 2.9 154.7 1.0 O A:GLY556 3.3 169.6 1.0 O B:HOH1201 3.5 162.1 1.0 CG B:ASP234 3.9 154.7 1.0 OD2 B:ASP234 4.1 154.7 1.0 C A:GLY556 4.1 169.6 1.0 O B:GLU231 4.3 156.9 1.0 CA A:GLY556 4.5 169.6 1.0 O B:GLU232 4.6 154.4 1.0

Calcium binding site 5 out of 6 in the Structure of Calcium-Sensing Receptor in Complex with Nps-2143


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Structure of Calcium-Sensing Receptor in Complex with Nps-2143 within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1102 b:206.8 occ:1.00 OG B:SER302 2.7 137.2 1.0 CB B:SER302 3.8 137.2 1.0 CH2 B:TRP1107 3.9 133.5 1.0 CE1 B:PHE42 4.0 144.9 1.0 CZ B:PHE42 4.2 144.9 1.0 CA B:SER302 4.2 137.2 1.0 NH1 B:ARG66 4.2 135.2 1.0 N B:SER303 4.5 133.3 1.0 CZ3 B:TRP1107 4.6 133.5 1.0 CZ2 B:TRP1107 4.9 133.5 1.0 C B:SER302 4.9 137.2 1.0 CD B:ARG66 5.0 135.2 1.0

Calcium binding site 6 out of 6 in the Structure of Calcium-Sensing Receptor in Complex with Nps-2143


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Structure of Calcium-Sensing Receptor in Complex with Nps-2143 within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1103 b:180.2 occ:1.00 OG1 B:THR145 2.7 143.6 1.0 OG1 B:THR100 2.8 141.1 1.0 O B:ALA144 2.8 135.4 1.0 CB B:THR100 3.7 141.1 1.0 CG1 B:VAL149 3.8 127.6 1.0 CG2 B:THR100 3.9 141.1 1.0 C B:ALA144 4.0 135.4 1.0 CB B:THR145 4.0 143.6 1.0 CB B:VAL149 4.2 127.6 1.0 CG2 B:VAL149 4.3 127.6 1.0 N B:GLY146 4.3 135.3 1.0 C B:THR145 4.4 143.6 1.0 CA B:ASN102 4.4 138.9 1.0 CD B:PRO39 4.4 133.7 1.0 CB B:PRO39 4.5 133.7 1.0 CA B:THR145 4.6 143.6 1.0 N B:PRO39 4.6 133.7 1.0 OD1 B:ASN102 4.6 138.9 1.0 N B:ASN102 4.7 138.9 1.0 N B:THR145 4.7 143.6 1.0 CG B:PRO39 4.7 133.7 1.0 O B:THR145 4.8 143.6 1.0 O B:LEU37 4.9 129.7 1.0 CA B:PRO39 4.9 133.7 1.0 CG2 B:THR145 5.0 143.6 1.0 CA B:GLY146 5.0 135.3 1.0

T.L.Wen, Z.Y.Wang, X.Z.Chen, Y.Ren, X.H.Lu, Y.F.Xing, J.Lu, S.H.Chang, X.Zhang, Y.Q.Shen, X.Yang. Structural Basis For Activation and Allosteric Modulation of Full-Length Calcium-Sensing Receptor. Sci Adv 2021.
ISSN: ESSN 2375-2548
PubMed: 34088669
DOI: 10.1126/SCIADV.ABG1483