Calcium in PDB 7dxb: Structure of TRPC3 at 2.7 Angstrom in High Calcium State

The structure of Structure of TRPC3 at 2.7 Angstrom in High Calcium State also contains other interesting chemical elements:

Zinc

(Zn)

4 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Calcium atom in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State (pdb code 7dxb). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 12 binding sites of Calcium where determined in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State, PDB code: 7dxb:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Calcium binding site 1 out of 12 in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of TRPC3 at 2.7 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca905 b:6.9 occ:1.00 OD1 A:ASP798 2.4 24.1 1.0 OE1 A:GLU73 2.5 18.1 1.0 O A:GLU73 2.6 8.5 1.0 CD A:GLU73 3.6 15.1 1.0 CG A:ASP798 3.6 16.1 1.0 C A:GLU73 3.8 4.4 1.0 OE2 A:GLU73 4.3 14.6 1.0 NZ B:LYS796 4.3 10.7 1.0 CA A:ASP798 4.3 3.1 1.0 OD2 A:ASP798 4.4 13.5 1.0 CB A:GLU73 4.5 3.7 1.0 CA A:HIS74 4.5 2.4 1.0 CB A:ASP798 4.5 5.0 1.0 N A:HIS74 4.6 2.7 1.0 CG A:GLU73 4.6 7.1 1.0 OG A:SER801 4.6 8.9 1.0 N A:LEU75 4.7 4.3 1.0 ND1 A:HIS74 4.8 0.7 1.0 CA A:GLU73 4.8 2.1 1.0 N A:ASP798 5.0 3.6 1.0

Calcium binding site 2 out of 12 in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of TRPC3 at 2.7 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca906 b:42.2 occ:1.00 OE2 A:GLU791 2.3 21.6 1.0 O A:GLU786 2.9 24.1 1.0 OE1 B:GLU789 2.9 22.2 1.0 ND2 A:ASN788 3.2 28.0 1.0 CD A:GLU791 3.5 20.2 1.0 CG A:ASN788 3.5 21.6 1.0 OD1 A:ASN788 3.6 26.4 1.0 CD B:GLU789 3.8 20.7 1.0 C A:GLU786 4.0 16.7 1.0 OE1 A:GLU791 4.0 23.7 1.0 N A:ASN788 4.0 12.6 1.0 CB A:ASP785 4.1 21.4 1.0 CB B:GLU789 4.3 8.9 1.0 CG B:GLU789 4.3 10.6 1.0 CA A:VAL787 4.4 9.9 1.0 CB A:ASN788 4.4 9.9 1.0 C A:VAL787 4.5 10.6 1.0 NZ A:LYS782 4.6 37.9 1.0 OE2 B:GLU789 4.6 22.1 1.0 N A:VAL787 4.6 11.3 1.0 CG A:GLU791 4.6 12.7 1.0 C A:ASP785 4.7 20.1 1.0 CA A:ASN788 4.8 9.7 1.0 N A:GLU786 4.8 21.8 1.0 O A:ASP785 4.9 21.6 1.0

Calcium binding site 3 out of 12 in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structure of TRPC3 at 2.7 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca907 b:133.2 occ:1.00 OD1 A:ASN458 2.4 100.0 1.0 OE1 A:GLU440 2.5 98.8 1.0 OE2 A:GLU443 2.6 111.7 1.0 OE2 A:GLU440 3.1 91.0 1.0 CD A:GLU440 3.1 87.4 1.0 CG A:ASN458 3.5 99.9 1.0 CD A:GLU443 3.6 111.5 1.0 OE1 A:GLU443 3.8 115.2 1.0 OD2 A:ASP461 4.0 92.2 1.0 ND2 A:ASN458 4.4 109.9 1.0 CA A:ASN458 4.4 89.6 1.0 CB A:ASN458 4.5 98.2 1.0 CG A:GLU440 4.6 76.3 1.0 CE2 A:TYR452 4.7 104.2 1.0 CG A:ASP461 4.9 82.4 1.0 CG A:GLU443 4.9 100.9 1.0 CB A:ASP461 4.9 68.4 1.0 N A:ASN458 4.9 92.8 1.0

Calcium binding site 4 out of 12 in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structure of TRPC3 at 2.7 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1106 b:6.9 occ:1.00 OD1 B:ASP798 2.4 24.1 1.0 OE1 B:GLU73 2.5 18.1 1.0 O B:GLU73 2.6 8.5 1.0 CD B:GLU73 3.6 15.1 1.0 CG B:ASP798 3.6 16.1 1.0 C B:GLU73 3.8 4.4 1.0 OE2 B:GLU73 4.3 14.6 1.0 NZ C:LYS796 4.3 10.7 1.0 CA B:ASP798 4.3 3.1 1.0 OD2 B:ASP798 4.4 13.5 1.0 CB B:GLU73 4.5 3.7 1.0 CA B:HIS74 4.5 2.4 1.0 CB B:ASP798 4.5 5.0 1.0 N B:HIS74 4.6 2.7 1.0 CG B:GLU73 4.6 7.1 1.0 OG B:SER801 4.6 8.9 1.0 N B:LEU75 4.7 4.3 1.0 ND1 B:HIS74 4.8 0.7 1.0 CA B:GLU73 4.8 2.1 1.0 N B:ASP798 5.0 3.6 1.0

Calcium binding site 5 out of 12 in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Structure of TRPC3 at 2.7 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1107 b:42.2 occ:1.00 OE2 B:GLU791 2.3 21.6 1.0 O B:GLU786 2.9 24.1 1.0 OE1 C:GLU789 2.9 22.2 1.0 ND2 B:ASN788 3.2 28.0 1.0 CD B:GLU791 3.5 20.2 1.0 CG B:ASN788 3.5 21.6 1.0 OD1 B:ASN788 3.6 26.4 1.0 CD C:GLU789 3.8 20.7 1.0 C B:GLU786 4.0 16.7 1.0 OE1 B:GLU791 4.0 23.7 1.0 N B:ASN788 4.0 12.6 1.0 CB B:ASP785 4.1 21.4 1.0 CB C:GLU789 4.3 8.9 1.0 CG C:GLU789 4.3 10.6 1.0 CA B:VAL787 4.4 9.9 1.0 CB B:ASN788 4.4 9.9 1.0 C B:VAL787 4.5 10.6 1.0 NZ B:LYS782 4.6 37.9 1.0 N B:VAL787 4.6 11.3 1.0 OE2 C:GLU789 4.6 22.1 1.0 CG B:GLU791 4.6 12.7 1.0 C B:ASP785 4.7 20.1 1.0 CA B:ASN788 4.8 9.7 1.0 N B:GLU786 4.8 21.8 1.0 O B:ASP785 4.9 21.6 1.0

Calcium binding site 6 out of 12 in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Structure of TRPC3 at 2.7 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1108 b:133.2 occ:1.00 OD1 B:ASN458 2.4 100.0 1.0 OE1 B:GLU440 2.5 98.8 1.0 OE2 B:GLU443 2.6 111.7 1.0 OE2 B:GLU440 3.1 91.0 1.0 CD B:GLU440 3.1 87.4 1.0 CG B:ASN458 3.5 99.9 1.0 CD B:GLU443 3.6 111.5 1.0 OE1 B:GLU443 3.8 115.2 1.0 OD2 B:ASP461 4.0 92.2 1.0 ND2 B:ASN458 4.4 109.9 1.0 CA B:ASN458 4.4 89.6 1.0 CB B:ASN458 4.5 98.2 1.0 CG B:GLU440 4.6 76.3 1.0 CE2 B:TYR452 4.7 104.2 1.0 CG B:ASP461 4.9 82.4 1.0 CG B:GLU443 4.9 100.9 1.0 CB B:ASP461 4.9 68.4 1.0 N B:ASN458 4.9 92.8 1.0

Calcium binding site 7 out of 12 in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Structure of TRPC3 at 2.7 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1106 b:6.9 occ:1.00 OD1 C:ASP798 2.4 24.1 1.0 OE1 C:GLU73 2.5 18.1 1.0 O C:GLU73 2.6 8.5 1.0 CD C:GLU73 3.6 15.1 1.0 CG C:ASP798 3.6 16.1 1.0 C C:GLU73 3.8 4.4 1.0 OE2 C:GLU73 4.3 14.6 1.0 NZ D:LYS796 4.3 10.7 1.0 CA C:ASP798 4.3 3.1 1.0 OD2 C:ASP798 4.4 13.5 1.0 CB C:GLU73 4.5 3.7 1.0 CA C:HIS74 4.5 2.4 1.0 CB C:ASP798 4.5 5.0 1.0 N C:HIS74 4.6 2.7 1.0 CG C:GLU73 4.6 7.1 1.0 OG C:SER801 4.6 8.9 1.0 N C:LEU75 4.7 4.3 1.0 ND1 C:HIS74 4.8 0.7 1.0 CA C:GLU73 4.8 2.1 1.0 N C:ASP798 5.0 3.6 1.0

Calcium binding site 8 out of 12 in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 8 of Structure of TRPC3 at 2.7 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1107 b:42.2 occ:1.00 OE2 C:GLU791 2.3 21.6 1.0 O C:GLU786 2.9 24.1 1.0 OE1 D:GLU789 2.9 22.2 1.0 ND2 C:ASN788 3.2 28.0 1.0 CD C:GLU791 3.5 20.2 1.0 CG C:ASN788 3.5 21.6 1.0 OD1 C:ASN788 3.6 26.4 1.0 CD D:GLU789 3.8 20.7 1.0 C C:GLU786 4.0 16.7 1.0 OE1 C:GLU791 4.0 23.7 1.0 N C:ASN788 4.0 12.6 1.0 CB C:ASP785 4.1 21.4 1.0 CB D:GLU789 4.3 8.9 1.0 CG D:GLU789 4.3 10.6 1.0 CA C:VAL787 4.4 9.9 1.0 CB C:ASN788 4.4 9.9 1.0 C C:VAL787 4.6 10.6 1.0 NZ C:LYS782 4.6 37.9 1.0 OE2 D:GLU789 4.6 22.1 1.0 N C:VAL787 4.6 11.3 1.0 CG C:GLU791 4.6 12.7 1.0 C C:ASP785 4.7 20.1 1.0 CA C:ASN788 4.8 9.7 1.0 N C:GLU786 4.8 21.8 1.0 O C:ASP785 4.9 21.6 1.0

Calcium binding site 9 out of 12 in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 9 of Structure of TRPC3 at 2.7 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1108 b:133.2 occ:1.00 OD1 C:ASN458 2.4 100.0 1.0 OE1 C:GLU440 2.5 98.8 1.0 OE2 C:GLU443 2.6 111.7 1.0 OE2 C:GLU440 3.1 91.0 1.0 CD C:GLU440 3.1 87.4 1.0 CG C:ASN458 3.5 99.9 1.0 CD C:GLU443 3.6 111.5 1.0 OE1 C:GLU443 3.8 115.2 1.0 OD2 C:ASP461 4.0 92.2 1.0 ND2 C:ASN458 4.4 109.9 1.0 CA C:ASN458 4.4 89.6 1.0 CB C:ASN458 4.5 98.2 1.0 CG C:GLU440 4.6 76.3 1.0 CE2 C:TYR452 4.7 104.2 1.0 CG C:ASP461 4.9 82.4 1.0 CG C:GLU443 4.9 100.9 1.0 CB C:ASP461 4.9 68.4 1.0 N C:ASN458 4.9 92.8 1.0

Calcium binding site 10 out of 12 in the Structure of TRPC3 at 2.7 Angstrom in High Calcium State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 10 of Structure of TRPC3 at 2.7 Angstrom in High Calcium State within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1105 b:6.9 occ:1.00 OD1 D:ASP798 2.4 24.1 1.0 OE1 D:GLU73 2.5 18.1 1.0 O D:GLU73 2.6 8.5 1.0 CD D:GLU73 3.6 15.1 1.0 CG D:ASP798 3.6 16.1 1.0 C D:GLU73 3.8 4.4 1.0 OE2 D:GLU73 4.3 14.6 1.0 NZ A:LYS796 4.3 10.7 1.0 CA D:ASP798 4.3 3.1 1.0 OD2 D:ASP798 4.4 13.5 1.0 CB D:GLU73 4.5 3.7 1.0 CA D:HIS74 4.5 2.4 1.0 CB D:ASP798 4.5 5.0 1.0 N D:HIS74 4.6 2.7 1.0 CG D:GLU73 4.6 7.1 1.0 OG D:SER801 4.6 8.9 1.0 N D:LEU75 4.7 4.3 1.0 ND1 D:HIS74 4.8 0.7 1.0 CA D:GLU73 4.8 2.1 1.0 N D:ASP798 5.0 3.6 1.0

W.Guo, Q.Tang, M.Wei, Y.Kang, J.X.Wu, L.Chen. Structural Mechanism of Human TRPC3 and TRPC6 Channel Regulation By Their Intracellular Calcium-Binding Sites. Neuron V. 110 1023 2022.
ISSN: ISSN 0896-6273
PubMed: 35051376
DOI: 10.1016/J.NEURON.2021.12.023