Atomistry » Calcium » PDB 7et8-7f9d » 7f99
Atomistry »
  Calcium »
    PDB 7et8-7f9d »
      7f99 »

Calcium in PDB 7f99: Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96

Enzymatic activity of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96

All present enzymatic activity of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96:
6.1.1.15; 6.1.1.17;

Protein crystallography data

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96, PDB code: 7f99 was solved by Y.Manickam, N.Malhotra, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 78.25 / 1.98
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 70.471, 91.518, 83.335, 90, 110.11, 90
R / Rfree (%) 18.1 / 22.8

Other elements in 7f99:

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms
Zinc (Zn) 2 atoms
Fluorine (F) 2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 (pdb code 7f99). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96, PDB code: 7f99:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in 7f99

Go back to Calcium Binding Sites List in 7f99
Calcium binding site 1 out of 4 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1903

b:81.1
occ:1.00
 O A:HOH2218 2.5 40.4 1.0
O A:HOH2163 2.8 53.9 1.0
OE1 A:GLN1378 2.8 57.8 1.0
OG A:SER1376 2.9 74.1 1.0
O A:SER1376 3.2 52.0 1.0
CD A:GLN1378 3.8 60.1 1.0
CB A:SER1376 4.2 66.2 1.0
C A:SER1376 4.3 55.2 1.0
CB A:GLN1378 4.6 56.2 1.0
CG A:GLN1378 4.7 54.2 1.0
NE2 A:GLN1378 4.7 56.3 1.0
CA A:SER1376 4.8 59.0 1.0

Calcium binding site 2 out of 4 in 7f99

Go back to Calcium Binding Sites List in 7f99
Calcium binding site 2 out of 4 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1904

b:51.6
occ:0.77
 O A:HOH2145 2.3 61.7 1.0
OE2 A:GLU1100 2.4 61.4 1.0
O A:ASP1096 2.5 36.6 1.0
O A:HOH2031 2.6 64.1 1.0
CD A:GLU1100 3.2 56.7 1.0
OE1 A:GLU1100 3.2 56.9 1.0
OD2 A:ASP1096 3.4 63.7 1.0
O A:HOH2119 3.5 61.2 1.0
C A:ASP1096 3.7 36.5 1.0
CG A:ASP1096 4.2 56.1 1.0
O A:HOH2015 4.3 44.3 1.0
O A:HOH2112 4.4 49.8 1.0
CA A:PHE1097 4.4 31.1 1.0
CA A:ASP1096 4.5 37.2 1.0
N A:PHE1097 4.5 31.2 1.0
CG A:GLU1100 4.7 42.5 1.0
OD1 A:ASP1096 4.8 67.1 1.0
CB A:ASP1096 4.8 41.9 1.0
OE1 A:GLU1154 4.9 47.8 1.0

Calcium binding site 3 out of 4 in 7f99

Go back to Calcium Binding Sites List in 7f99
Calcium binding site 3 out of 4 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1905

b:60.8
occ:1.00
 OE1 A:GLU1264 2.4 55.0 1.0
O A:HOH2217 2.8 57.5 1.0
CD A:GLU1264 3.5 56.6 1.0
O A:HOH2193 3.6 62.9 1.0
OE2 A:GLU1264 4.3 53.9 1.0
O A:LYS1265 4.3 47.8 1.0
CG A:GLU1264 4.5 54.1 1.0
O A:HOH2180 4.6 50.6 1.0

Calcium binding site 4 out of 4 in 7f99

Go back to Calcium Binding Sites List in 7f99
Calcium binding site 4 out of 4 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca1903

b:77.5
occ:0.99
 O B:HOH2135 2.5 38.8 0.3
O B:HOH2043 2.6 47.0 0.6
O B:ASP1096 2.7 39.5 1.0
OE2 B:GLU1100 2.7 77.8 1.0
OE1 B:GLU1100 3.4 77.5 1.0
CD B:GLU1100 3.5 73.0 1.0
C B:ASP1096 3.9 41.7 1.0
O B:HOH2135 3.9 34.2 0.7
OD2 B:ASP1096 4.1 69.9 1.0
CG B:ASP1096 4.3 65.5 1.0
OD1 B:ASP1096 4.5 77.5 1.0
CA B:ASP1096 4.6 40.2 1.0
CA B:PHE1097 4.8 40.5 1.0
N B:PHE1097 4.8 39.6 1.0
O B:HOH2050 4.9 42.2 1.0
CG B:GLU1100 4.9 49.5 1.0

Reference:

N.Malhotra, Y.Manickam, A.Sharma. Hsprs with Atp Binding Pocket Inhibitor To Be Published.
Page generated: Fri Jul 19 00:38:51 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy