Calcium in PDB 7k66: Structure of Blood Coagulation Factor VIII in Complex with An Anti-C1 Domain Pathogenic Antibody Inhibitor

The structure of Structure of Blood Coagulation Factor VIII in Complex with An Anti-C1 Domain Pathogenic Antibody Inhibitor, PDB code: 7k66 was solved by K.C.Childers, J.Gish, L.Jarvis, S.Peters, C.Garrels, I.W.Smith, H.T.Spencer, P.C.Spiegel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.49 / 3.92
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	116.721, 116.721, 371.057, 90.00, 90.00, 90.00
R / Rfree (%)	22.6 / 32.2

The structure of Structure of Blood Coagulation Factor VIII in Complex with An Anti-C1 Domain Pathogenic Antibody Inhibitor also contains other interesting chemical elements:

Copper	(Cu)	1 atom
Zinc	(Zn)	1 atom

The binding sites of Calcium atom in the Structure of Blood Coagulation Factor VIII in Complex with An Anti-C1 Domain Pathogenic Antibody Inhibitor (pdb code 7k66). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Structure of Blood Coagulation Factor VIII in Complex with An Anti-C1 Domain Pathogenic Antibody Inhibitor, PDB code: 7k66:

Calcium binding site 1 out of 1 in the Structure of Blood Coagulation Factor VIII in Complex with An Anti-C1 Domain Pathogenic Antibody Inhibitor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Blood Coagulation Factor VIII in Complex with An Anti-C1 Domain Pathogenic Antibody Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2403 b:0.2 occ:1.00 O A:LYS108 2.4 0.2 1.0 O A:GLU123 2.4 0.2 1.0 OD1 A:ASP127 2.5 0.0 1.0 OD2 A:ASP126 2.6 0.2 1.0 OD2 A:ASP127 3.1 0.0 1.0 CG A:ASP127 3.1 0.6 1.0 CG A:ASP126 3.4 0.2 1.0 OD1 A:ASP126 3.4 0.4 1.0 C A:GLU123 3.5 0.3 1.0 C A:LYS108 3.6 0.7 1.0 CD A:LYS108 3.6 0.7 1.0 CA A:LYS124 3.9 0.7 1.0 CB A:GLU111 4.0 0.7 1.0 NZ A:LYS108 4.0 0.2 1.0 N A:LYS124 4.1 0.1 1.0 N A:GLU111 4.3 0.4 1.0 CA A:LYS108 4.4 0.2 1.0 CE A:LYS108 4.4 0.8 1.0 O A:ALA113 4.4 0.3 1.0 OE1 A:GLU111 4.5 0.2 1.0 N A:SER109 4.6 0.0 1.0 CB A:ASP127 4.6 0.6 1.0 C A:LYS124 4.6 0.7 1.0 CA A:GLU123 4.7 0.6 1.0 N A:ASP127 4.7 0.2 1.0 CA A:GLU111 4.7 0.7 1.0 N A:SER110 4.8 0.9 1.0 CB A:ASP126 4.8 0.0 1.0 CA A:SER109 4.8 0.9 1.0 CG A:LYS108 4.8 0.1 1.0 CB A:LYS108 4.8 0.2 1.0 N A:GLY112 4.9 0.6 1.0 O A:LYS124 4.9 0.5 1.0 CG A:LYS124 4.9 0.1 1.0 CB A:GLU123 4.9 0.7 1.0 CB A:LYS124 5.0 0.2 1.0 C A:SER109 5.0 0.5 1.0

J.Gish, L.Jarvis, K.C.Childers, S.Peters, C.Garrels, I.W.Smith, H.T.Spencer, P.Lollar, C.B.Doering, P.C.Spiegel. Structure of Blood Coagulation Factor VIII in Complex with An Anti-C1 Domain Pathogenic Antibody Inhibitor To Be Published.