Calcium in PDB 7koq: Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State

The structure of Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State also contains other interesting chemical elements:

Chlorine

(Cl)

5 atoms

The binding sites of Calcium atom in the Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State (pdb code 7koq). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 5 binding sites of Calcium where determined in the Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State, PDB code: 7koq:
Jump to Calcium binding site number: 1; 2; 3; 4; 5;

Calcium binding site 1 out of 5 in the Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca504 b:57.7 occ:1.00 HH21 A:ARG205 3.1 57.1 1.0 OE1 A:GLU44 3.5 58.7 1.0 NH2 A:ARG205 3.7 57.1 1.0 HH22 A:ARG205 3.7 57.1 1.0 OE2 A:GLU44 3.7 58.7 1.0 O A:VAL42 3.8 49.0 1.0 CD A:GLU44 3.9 58.7 1.0 HB A:VAL42 4.0 49.0 1.0 OE1 A:GLU172 4.1 57.4 1.0 HE1 A:TRP173 4.3 54.2 1.0 HH A:TYR210 4.3 63.8 1.0 HZ2 A:TRP173 4.3 54.2 1.0 OE2 A:GLU172 4.3 57.4 1.0 CD A:GLU172 4.4 57.4 1.0 C A:VAL42 4.7 49.0 1.0 H A:GLU44 4.7 58.7 1.0 HA A:ASP43 4.8 55.2 1.0 CB A:VAL42 4.9 49.0 1.0 HE A:ARG205 4.9 57.1 1.0 HG12 A:VAL42 4.9 49.0 1.0 H A:VAL42 4.9 49.0 1.0 CZ A:ARG205 5.0 57.1 1.0 NE1 A:TRP173 5.0 54.2 1.0

Calcium binding site 2 out of 5 in the Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca504 b:58.7 occ:1.00 HH21 B:ARG205 3.0 57.5 1.0 OE1 B:GLU44 3.3 58.1 1.0 OE2 B:GLU44 3.5 58.1 1.0 HH22 B:ARG205 3.6 57.5 1.0 NH2 B:ARG205 3.6 57.5 1.0 CD B:GLU44 3.7 58.1 1.0 O B:VAL42 3.8 49.0 1.0 HB B:VAL42 4.1 49.0 1.0 HH B:TYR210 4.2 64.2 1.0 HZ2 B:TRP173 4.3 55.0 1.0 H B:GLU44 4.4 58.1 1.0 OE1 B:GLU172 4.4 58.0 1.0 HE1 B:TRP173 4.5 55.0 1.0 OE2 B:GLU172 4.6 58.0 1.0 HA B:ASP43 4.7 54.6 1.0 C B:VAL42 4.7 49.0 1.0 CD B:GLU172 4.7 58.0 1.0 HG12 B:VAL42 4.9 49.0 1.0 CZ B:ARG205 4.9 57.5 1.0 HB2 B:GLU44 5.0 58.1 1.0 HE B:ARG205 5.0 57.5 1.0 CG B:GLU44 5.0 58.1 1.0 CB B:VAL42 5.0 49.0 1.0

Calcium binding site 3 out of 5 in the Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca504 b:59.8 occ:1.00 HH21 C:ARG205 3.0 57.5 1.0 OE1 C:GLU44 3.2 59.0 1.0 OE2 C:GLU44 3.5 59.0 1.0 HH22 C:ARG205 3.5 57.5 1.0 NH2 C:ARG205 3.6 57.5 1.0 CD C:GLU44 3.6 59.0 1.0 O C:VAL42 3.8 49.5 1.0 HB C:VAL42 4.1 49.5 1.0 HH C:TYR210 4.2 64.0 1.0 HZ2 C:TRP173 4.3 55.2 1.0 H C:GLU44 4.4 59.0 1.0 OE1 C:GLU172 4.4 58.1 1.0 HE1 C:TRP173 4.5 55.2 1.0 OE2 C:GLU172 4.6 58.1 1.0 HA C:ASP43 4.7 54.8 1.0 C C:VAL42 4.7 49.5 1.0 CD C:GLU172 4.8 58.1 1.0 HG12 C:VAL42 4.8 49.5 1.0 CZ C:ARG205 4.9 57.5 1.0 HE C:ARG205 4.9 57.5 1.0 CG C:GLU44 4.9 59.0 1.0 HB2 C:GLU44 4.9 59.0 1.0 CB C:VAL42 5.0 49.5 1.0 OH C:TYR210 5.0 64.0 1.0

Calcium binding site 4 out of 5 in the Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca504 b:63.1 occ:1.00 HH21 D:ARG205 3.0 56.6 1.0 OE1 D:GLU44 3.3 57.7 1.0 HH22 D:ARG205 3.5 56.6 1.0 OE2 D:GLU44 3.6 57.7 1.0 NH2 D:ARG205 3.6 56.6 1.0 CD D:GLU44 3.7 57.7 1.0 O D:VAL42 3.9 49.5 1.0 HB D:VAL42 4.1 49.5 1.0 HH D:TYR210 4.2 63.2 1.0 HZ2 D:TRP173 4.3 54.4 1.0 OE1 D:GLU172 4.3 57.6 1.0 HE1 D:TRP173 4.4 54.4 1.0 OE2 D:GLU172 4.5 57.6 1.0 H D:GLU44 4.5 57.7 1.0 CD D:GLU172 4.6 57.6 1.0 C D:VAL42 4.7 49.5 1.0 HA D:ASP43 4.8 54.3 1.0 CZ D:ARG205 4.8 56.6 1.0 HE D:ARG205 4.9 56.6 1.0 HG12 D:VAL42 4.9 49.5 1.0 OH D:TYR210 5.0 63.2 1.0 CB D:VAL42 5.0 49.5 1.0

Calcium binding site 5 out of 5 in the Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca504 b:58.3 occ:1.00 HH21 E:ARG205 3.0 56.7 1.0 OE1 E:GLU44 3.2 58.9 1.0 OE2 E:GLU44 3.5 58.9 1.0 HH22 E:ARG205 3.5 56.7 1.0 NH2 E:ARG205 3.6 56.7 1.0 CD E:GLU44 3.7 58.9 1.0 O E:VAL42 3.8 48.5 1.0 HB E:VAL42 4.1 48.5 1.0 HH E:TYR210 4.2 64.3 1.0 HZ2 E:TRP173 4.3 54.0 1.0 OE1 E:GLU172 4.4 57.2 1.0 HE1 E:TRP173 4.5 54.0 1.0 H E:GLU44 4.5 58.9 1.0 OE2 E:GLU172 4.6 57.2 1.0 CD E:GLU172 4.7 57.2 1.0 C E:VAL42 4.7 48.5 1.0 HA E:ASP43 4.7 54.7 1.0 CZ E:ARG205 4.8 56.7 1.0 HE E:ARG205 4.9 56.7 1.0 HG12 E:VAL42 4.9 48.5 1.0 OH E:TYR210 5.0 64.3 1.0 CG E:GLU44 5.0 58.9 1.0 HB2 E:GLU44 5.0 58.9 1.0

C.M.Noviello, R.E.Hibbs. Structure and Gating Mechanism of the Alpha-7 Nicotinic Acetylcholine Receptor Cell(Cambridge,Mass.) 2021.
ISSN: ISSN 0092-8674
DOI: 10.1016/J.CELL.2021.02.049