Calcium in PDB 7mbu: Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain)
Calcium Binding Sites:
The binding sites of Calcium atom in the Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain)
(pdb code 7mbu). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the
Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain), PDB code: 7mbu:
Jump to Calcium binding site number:
1;
2;
3;
4;
Calcium binding site 1 out
of 4 in 7mbu
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Calcium Binding Sites List in 7mbu
Calcium binding site 1 out
of 4 in the Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain)
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Ca1502
b:101.3
occ:1.00
|
OD2
|
A:ASP797
|
2.5
|
99.5
|
1.0
|
OE1
|
A:GLU768
|
2.6
|
101.9
|
1.0
|
OD1
|
A:ASN794
|
2.7
|
100.7
|
1.0
|
OE2
|
A:GLU768
|
2.8
|
101.9
|
1.0
|
OE1
|
A:GLN771
|
3.0
|
100.8
|
1.0
|
CD
|
A:GLU768
|
3.1
|
101.9
|
1.0
|
NH1
|
A:ARG834
|
3.5
|
89.1
|
1.0
|
CG
|
A:ASP797
|
3.7
|
99.5
|
1.0
|
CD
|
A:GLN771
|
3.9
|
100.8
|
1.0
|
CG
|
A:ASN794
|
3.9
|
100.7
|
1.0
|
NE2
|
A:GLN771
|
4.0
|
100.8
|
1.0
|
CB
|
A:ASP797
|
4.3
|
99.5
|
1.0
|
CG
|
A:GLU768
|
4.6
|
101.9
|
1.0
|
CA
|
A:ASN794
|
4.6
|
100.7
|
1.0
|
OD1
|
A:ASP797
|
4.7
|
99.5
|
1.0
|
CZ
|
A:ARG834
|
4.7
|
89.1
|
1.0
|
ND2
|
A:ASN794
|
4.8
|
100.7
|
1.0
|
CB
|
A:ASN794
|
4.9
|
100.7
|
1.0
|
O
|
A:TRP793
|
4.9
|
95.3
|
1.0
|
N
|
A:ASN794
|
5.0
|
100.7
|
1.0
|
|
Calcium binding site 2 out
of 4 in 7mbu
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Calcium Binding Sites List in 7mbu
Calcium binding site 2 out
of 4 in the Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain)
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 2 of Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Ca1502
b:101.3
occ:1.00
|
OD2
|
B:ASP797
|
2.5
|
99.5
|
1.0
|
OE1
|
B:GLU768
|
2.6
|
101.9
|
1.0
|
OD1
|
B:ASN794
|
2.7
|
100.7
|
1.0
|
OE2
|
B:GLU768
|
2.8
|
101.9
|
1.0
|
OE1
|
B:GLN771
|
3.0
|
100.8
|
1.0
|
CD
|
B:GLU768
|
3.1
|
101.9
|
1.0
|
NH1
|
B:ARG834
|
3.5
|
89.1
|
1.0
|
CG
|
B:ASP797
|
3.7
|
99.5
|
1.0
|
CD
|
B:GLN771
|
3.9
|
100.8
|
1.0
|
CG
|
B:ASN794
|
3.9
|
100.7
|
1.0
|
NE2
|
B:GLN771
|
4.0
|
100.8
|
1.0
|
CB
|
B:ASP797
|
4.3
|
99.5
|
1.0
|
CG
|
B:GLU768
|
4.6
|
101.9
|
1.0
|
CA
|
B:ASN794
|
4.6
|
100.7
|
1.0
|
OD1
|
B:ASP797
|
4.7
|
99.5
|
1.0
|
CZ
|
B:ARG834
|
4.7
|
89.1
|
1.0
|
ND2
|
B:ASN794
|
4.8
|
100.7
|
1.0
|
CB
|
B:ASN794
|
4.8
|
100.7
|
1.0
|
O
|
B:TRP793
|
4.9
|
95.3
|
1.0
|
N
|
B:ASN794
|
5.0
|
100.7
|
1.0
|
|
Calcium binding site 3 out
of 4 in 7mbu
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Calcium Binding Sites List in 7mbu
Calcium binding site 3 out
of 4 in the Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain)
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 3 of Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Ca1502
b:101.3
occ:1.00
|
OD2
|
C:ASP797
|
2.5
|
99.5
|
1.0
|
OE1
|
C:GLU768
|
2.6
|
101.9
|
1.0
|
OD1
|
C:ASN794
|
2.7
|
100.7
|
1.0
|
OE2
|
C:GLU768
|
2.8
|
101.9
|
1.0
|
OE1
|
C:GLN771
|
3.0
|
100.8
|
1.0
|
CD
|
C:GLU768
|
3.1
|
101.9
|
1.0
|
NH1
|
C:ARG834
|
3.5
|
89.1
|
1.0
|
CG
|
C:ASP797
|
3.7
|
99.5
|
1.0
|
CD
|
C:GLN771
|
3.9
|
100.8
|
1.0
|
CG
|
C:ASN794
|
3.9
|
100.7
|
1.0
|
NE2
|
C:GLN771
|
4.0
|
100.8
|
1.0
|
CB
|
C:ASP797
|
4.3
|
99.5
|
1.0
|
CG
|
C:GLU768
|
4.6
|
101.9
|
1.0
|
CA
|
C:ASN794
|
4.6
|
100.7
|
1.0
|
OD1
|
C:ASP797
|
4.7
|
99.5
|
1.0
|
CZ
|
C:ARG834
|
4.7
|
89.1
|
1.0
|
ND2
|
C:ASN794
|
4.8
|
100.7
|
1.0
|
CB
|
C:ASN794
|
4.8
|
100.7
|
1.0
|
O
|
C:TRP793
|
4.9
|
95.3
|
1.0
|
N
|
C:ASN794
|
5.0
|
100.7
|
1.0
|
|
Calcium binding site 4 out
of 4 in 7mbu
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Calcium Binding Sites List in 7mbu
Calcium binding site 4 out
of 4 in the Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain)
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 4 of Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Ca1502
b:101.3
occ:1.00
|
OD2
|
D:ASP797
|
2.5
|
99.5
|
1.0
|
OE1
|
D:GLU768
|
2.6
|
101.9
|
1.0
|
OD1
|
D:ASN794
|
2.7
|
100.7
|
1.0
|
OE2
|
D:GLU768
|
2.8
|
101.9
|
1.0
|
OE1
|
D:GLN771
|
3.0
|
100.8
|
1.0
|
CD
|
D:GLU768
|
3.1
|
101.9
|
1.0
|
NH1
|
D:ARG834
|
3.5
|
89.1
|
1.0
|
CG
|
D:ASP797
|
3.7
|
99.5
|
1.0
|
CD
|
D:GLN771
|
3.9
|
100.8
|
1.0
|
CG
|
D:ASN794
|
3.9
|
100.7
|
1.0
|
NE2
|
D:GLN771
|
4.0
|
100.8
|
1.0
|
CB
|
D:ASP797
|
4.3
|
99.5
|
1.0
|
CG
|
D:GLU768
|
4.6
|
101.9
|
1.0
|
CA
|
D:ASN794
|
4.6
|
100.7
|
1.0
|
OD1
|
D:ASP797
|
4.7
|
99.5
|
1.0
|
CZ
|
D:ARG834
|
4.7
|
89.1
|
1.0
|
ND2
|
D:ASN794
|
4.8
|
100.7
|
1.0
|
CB
|
D:ASN794
|
4.8
|
100.7
|
1.0
|
O
|
D:TRP793
|
4.9
|
95.3
|
1.0
|
N
|
D:ASN794
|
5.0
|
100.7
|
1.0
|
|
Reference:
Z.Ruan,
E.Haley,
I.J.Orozco,
M.Sabat,
R.Myers,
R.Roth,
J.Du,
W.Lu.
Structures of the TRPM5 Channel Elucidate Mechanisms of Activation and Inhibition. Nat.Struct.Mol.Biol. 2021.
ISSN: ESSN 1545-9985
PubMed: 34168372
DOI: 10.1038/S41594-021-00607-4
Page generated: Fri Jul 19 01:59:02 2024
|