Calcium in PDB 7mbu: Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain)

The binding sites of Calcium atom in the Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain) (pdb code 7mbu). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain), PDB code: 7mbu:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1502 b:101.3 occ:1.00 OD2 A:ASP797 2.5 99.5 1.0 OE1 A:GLU768 2.6 101.9 1.0 OD1 A:ASN794 2.7 100.7 1.0 OE2 A:GLU768 2.8 101.9 1.0 OE1 A:GLN771 3.0 100.8 1.0 CD A:GLU768 3.1 101.9 1.0 NH1 A:ARG834 3.5 89.1 1.0 CG A:ASP797 3.7 99.5 1.0 CD A:GLN771 3.9 100.8 1.0 CG A:ASN794 3.9 100.7 1.0 NE2 A:GLN771 4.0 100.8 1.0 CB A:ASP797 4.3 99.5 1.0 CG A:GLU768 4.6 101.9 1.0 CA A:ASN794 4.6 100.7 1.0 OD1 A:ASP797 4.7 99.5 1.0 CZ A:ARG834 4.7 89.1 1.0 ND2 A:ASN794 4.8 100.7 1.0 CB A:ASN794 4.9 100.7 1.0 O A:TRP793 4.9 95.3 1.0 N A:ASN794 5.0 100.7 1.0

Calcium binding site 2 out of 4 in the Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain) within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1502 b:101.3 occ:1.00 OD2 B:ASP797 2.5 99.5 1.0 OE1 B:GLU768 2.6 101.9 1.0 OD1 B:ASN794 2.7 100.7 1.0 OE2 B:GLU768 2.8 101.9 1.0 OE1 B:GLN771 3.0 100.8 1.0 CD B:GLU768 3.1 101.9 1.0 NH1 B:ARG834 3.5 89.1 1.0 CG B:ASP797 3.7 99.5 1.0 CD B:GLN771 3.9 100.8 1.0 CG B:ASN794 3.9 100.7 1.0 NE2 B:GLN771 4.0 100.8 1.0 CB B:ASP797 4.3 99.5 1.0 CG B:GLU768 4.6 101.9 1.0 CA B:ASN794 4.6 100.7 1.0 OD1 B:ASP797 4.7 99.5 1.0 CZ B:ARG834 4.7 89.1 1.0 ND2 B:ASN794 4.8 100.7 1.0 CB B:ASN794 4.8 100.7 1.0 O B:TRP793 4.9 95.3 1.0 N B:ASN794 5.0 100.7 1.0

Calcium binding site 3 out of 4 in the Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain) within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1502 b:101.3 occ:1.00 OD2 C:ASP797 2.5 99.5 1.0 OE1 C:GLU768 2.6 101.9 1.0 OD1 C:ASN794 2.7 100.7 1.0 OE2 C:GLU768 2.8 101.9 1.0 OE1 C:GLN771 3.0 100.8 1.0 CD C:GLU768 3.1 101.9 1.0 NH1 C:ARG834 3.5 89.1 1.0 CG C:ASP797 3.7 99.5 1.0 CD C:GLN771 3.9 100.8 1.0 CG C:ASN794 3.9 100.7 1.0 NE2 C:GLN771 4.0 100.8 1.0 CB C:ASP797 4.3 99.5 1.0 CG C:GLU768 4.6 101.9 1.0 CA C:ASN794 4.6 100.7 1.0 OD1 C:ASP797 4.7 99.5 1.0 CZ C:ARG834 4.7 89.1 1.0 ND2 C:ASN794 4.8 100.7 1.0 CB C:ASN794 4.8 100.7 1.0 O C:TRP793 4.9 95.3 1.0 N C:ASN794 5.0 100.7 1.0

Calcium binding site 4 out of 4 in the Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Cryo-Em Structure of Zebrafish TRPM5 E337A Mutant in the Presence of 5 Mm Calcium (High Calcium Occupancy in the Transmembrane Domain) within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1502 b:101.3 occ:1.00 OD2 D:ASP797 2.5 99.5 1.0 OE1 D:GLU768 2.6 101.9 1.0 OD1 D:ASN794 2.7 100.7 1.0 OE2 D:GLU768 2.8 101.9 1.0 OE1 D:GLN771 3.0 100.8 1.0 CD D:GLU768 3.1 101.9 1.0 NH1 D:ARG834 3.5 89.1 1.0 CG D:ASP797 3.7 99.5 1.0 CD D:GLN771 3.9 100.8 1.0 CG D:ASN794 3.9 100.7 1.0 NE2 D:GLN771 4.0 100.8 1.0 CB D:ASP797 4.3 99.5 1.0 CG D:GLU768 4.6 101.9 1.0 CA D:ASN794 4.6 100.7 1.0 OD1 D:ASP797 4.7 99.5 1.0 CZ D:ARG834 4.7 89.1 1.0 ND2 D:ASN794 4.8 100.7 1.0 CB D:ASN794 4.8 100.7 1.0 O D:TRP793 4.9 95.3 1.0 N D:ASN794 5.0 100.7 1.0

Z.Ruan, E.Haley, I.J.Orozco, M.Sabat, R.Myers, R.Roth, J.Du, W.Lu. Structures of the TRPM5 Channel Elucidate Mechanisms of Activation and Inhibition. Nat.Struct.Mol.Biol. 2021.
ISSN: ESSN 1545-9985
PubMed: 34168372
DOI: 10.1038/S41594-021-00607-4