Calcium in PDB 7mxx: Crystal Structure of Human Exonuclease 1 EXO1 (R92A) in Complex with 5' Flap Dna (UF4)

The structure of Crystal Structure of Human Exonuclease 1 EXO1 (R92A) in Complex with 5' Flap Dna (UF4), PDB code: 7mxx was solved by Y.Shi, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	32.45 / 2.85
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	70.885, 70.885, 182.462, 90, 90, 90
R / Rfree (%)	25.8 / 29.8

The structure of Crystal Structure of Human Exonuclease 1 EXO1 (R92A) in Complex with 5' Flap Dna (UF4) also contains other interesting chemical elements:

Manganese

(Mn)

4 atoms

The binding sites of Calcium atom in the Crystal Structure of Human Exonuclease 1 EXO1 (R92A) in Complex with 5' Flap Dna (UF4) (pdb code 7mxx). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Crystal Structure of Human Exonuclease 1 EXO1 (R92A) in Complex with 5' Flap Dna (UF4), PDB code: 7mxx:

Calcium binding site 1 out of 1 in the Crystal Structure of Human Exonuclease 1 EXO1 (R92A) in Complex with 5' Flap Dna (UF4)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Human Exonuclease 1 EXO1 (R92A) in Complex with 5' Flap Dna (UF4) within 5.0Å range: probe atom residue distance (Å) B Occ Z:Ca405 b:102.3 occ:1.00 OD1 Z:ASP208 2.8 79.8 1.0 O Z:ALA245 2.9 100.8 1.0 O Z:ARG243 3.2 95.7 1.0 OD1 Z:ASN246 3.5 114.2 1.0 CG Z:ASP208 3.5 79.9 1.0 OD2 Z:ASP208 3.6 79.5 1.0 C Z:ARG243 4.0 94.3 1.0 C Z:ALA245 4.0 99.1 1.0 O Z:LEU242 4.1 85.0 1.0 NZ Z:LYS214 4.2 70.5 1.0 N Z:ALA245 4.4 100.5 1.0 CA Z:ARG243 4.5 94.3 1.0 CG Z:ASN246 4.7 115.4 1.0 N Z:LEU244 4.9 96.9 1.0 CA Z:ALA245 4.9 98.2 1.0 CB Z:ASP208 4.9 80.7 1.0 N Z:ASN246 5.0 107.5 1.0 C Z:LEU244 5.0 94.6 1.0

Y.Shi, H.W.Hellinga, L.S.Beese. Structures of Reaction Intermediates Reveal Transient MG2+-Binding Events That Dynamically Coordinate Human Exonuclease I Activities To Be Published.