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Atomistry » Calcium » PDB 7o22-7osk » 7oo7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Calcium » PDB 7o22-7osk » 7oo7 » |
Calcium in PDB 7oo7: KRASG12C Ligand ComplexEnzymatic activity of KRASG12C Ligand Complex
All present enzymatic activity of KRASG12C Ligand Complex:
3.6.5.2; Protein crystallography data
The structure of KRASG12C Ligand Complex, PDB code: 7oo7
was solved by
C.Phillips,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7oo7:
The structure of KRASG12C Ligand Complex also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the KRASG12C Ligand Complex
(pdb code 7oo7). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the KRASG12C Ligand Complex, PDB code: 7oo7: Calcium binding site 1 out of 1 in 7oo7Go back to Calcium Binding Sites List in 7oo7
Calcium binding site 1 out
of 1 in the KRASG12C Ligand Complex
Mono view Stereo pair view
Reference:
J.G.Kettle,
S.K.Bagal,
S.Bickerton,
M.S.Bodnarchuk,
S.Boyd,
J.Breed,
R.J.Carbajo,
D.J.Cassar,
A.Chakraborty,
S.Cosulich,
I.Cumming,
M.Davies,
N.L.Davies,
A.Eatherton,
L.Evans,
L.Feron,
S.Fillery,
E.S.Gleave,
F.W.Goldberg,
L.Hanson,
S.Harlfinger,
M.Howard,
R.Howells,
A.Jackson,
P.Kemmitt,
G.Lamont,
S.Lamont,
H.J.Lewis,
L.Liu,
M.J.Niedbala,
C.Phillips,
R.Polanski,
P.Raubo,
G.Robb,
D.M.Robinson,
S.Ross,
M.G.Sanders,
M.Tonge,
R.Whiteley,
S.Wilkinson,
J.Yang,
W.Zhang.
Discovery of AZD4625, A Covalent Allosteric Inhibitor of the Mutant Gtpase Kras G12C . J.Med.Chem. V. 65 6940 2022.
Page generated: Tue Apr 4 18:21:33 2023
ISSN: ISSN 0022-2623 PubMed: 35471939 DOI: 10.1021/ACS.JMEDCHEM.2C00369 |
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