Calcium in PDB 7pgn: Hhp-C in Complex with Glycosaminoglycan Mimic Sos

The structure of Hhp-C in Complex with Glycosaminoglycan Mimic Sos, PDB code: 7pgn was solved by S.C.Griffiths, R.A.Schwab, K.El Omari, B.Bishop, E.J.Iverson, T.Malinuskas, R.Dubey, M.Qian, D.F.Covey, R.J.C.Gilbert, R.Rohatgi, C.Siebold, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	58.09 / 2.40
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	100.56, 100.56, 311.88, 90, 90, 120
R / Rfree (%)	19 / 22.7

The binding sites of Calcium atom in the Hhp-C in Complex with Glycosaminoglycan Mimic Sos (pdb code 7pgn). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Hhp-C in Complex with Glycosaminoglycan Mimic Sos, PDB code: 7pgn:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Hhp-C in Complex with Glycosaminoglycan Mimic Sos


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Hhp-C in Complex with Glycosaminoglycan Mimic Sos within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca701 b:131.0 occ:1.00 O A:PRO432 4.0 80.9 1.0 CA A:GLY354 4.3 75.4 1.0 OE1 A:GLU281 4.4 92.0 1.0 N A:GLY354 4.5 87.5 1.0 O A:GLY354 4.6 80.6 1.0 C A:GLY354 4.8 80.7 1.0 CD A:GLU281 5.0 96.4 1.0

Calcium binding site 2 out of 2 in the Hhp-C in Complex with Glycosaminoglycan Mimic Sos


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Hhp-C in Complex with Glycosaminoglycan Mimic Sos within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca701 b:142.2 occ:1.00 OE2 B:GLU281 2.7 87.2 1.0 CD B:GLU281 3.7 85.1 1.0 OD2 B:ASP431 3.7 92.0 1.0 OD1 B:ASP431 3.9 89.5 1.0 CG B:ASP431 4.2 92.8 1.0 OE1 B:GLU281 4.4 80.4 1.0 CG B:GLU281 4.5 70.5 1.0

S.C.Griffiths, R.A.Schwab, K.El Omari, B.Bishop, E.J.Iverson, T.Malinuskas, R.Dubey, M.Qian, D.F.Covey, R.J.C.Gilbert, R.Rohatgi, C.Siebold. Hedgehog-Interacting Protein Is A Multimodal Antagonist of Hedgehog Signalling To Be Published.
DOI: 10.1038/S41467-021-27475-2