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Atomistry » Calcium » PDB 7qga-7rcc » 7qgm | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Calcium » PDB 7qga-7rcc » 7qgm » |
Calcium in PDB 7qgm: Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open StateEnzymatic activity of Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open State
All present enzymatic activity of Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open State:
3.1.3.5; Protein crystallography data
The structure of Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open State, PDB code: 7qgm
was solved by
N.S.Strater,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7qgm:
The structure of Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open State also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open State
(pdb code 7qgm). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open State, PDB code: 7qgm: Calcium binding site 1 out of 1 in 7qgmGo back to![]() ![]()
Calcium binding site 1 out
of 1 in the Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open State
![]() Mono view ![]() Stereo pair view
Reference:
M.Scortichini,
R.M.Idris,
S.Moschutz,
A.Keim,
V.Salmaso,
C.Dobelmann,
P.Oliva,
K.Losenkova,
H.Irjala,
S.Vaittinen,
J.Sandholm,
G.G.Yegutkin,
N.Strater,
A.Junker,
C.E.Muller,
K.A.Jacobson.
Structure-Activity Relationship of 3-Methylcytidine-5'-Alpha , Beta-Methylenediphosphates As CD73 Inhibitors. J.Med.Chem. V. 65 2409 2022.
Page generated: Fri Jul 19 03:28:36 2024
ISSN: ISSN 0022-2623 PubMed: 35080883 DOI: 10.1021/ACS.JMEDCHEM.1C01852 |
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