Calcium in PDB 7rde: Human Triose Phosphate Isomerase Q181P

All present enzymatic activity of Human Triose Phosphate Isomerase Q181P:
4.2.3.3; 5.3.1.1;

The structure of Human Triose Phosphate Isomerase Q181P, PDB code: 7rde was solved by A.P.Vandemark, J.Kowalski, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.33 / 1.31
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	73.189, 77.822, 84.295, 90, 90, 90
R / Rfree (%)	13.7 / 16.2

The structure of Human Triose Phosphate Isomerase Q181P also contains other interesting chemical elements:

Bromine

(Br)

2 atoms

The binding sites of Calcium atom in the Human Triose Phosphate Isomerase Q181P (pdb code 7rde). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Human Triose Phosphate Isomerase Q181P, PDB code: 7rde:

Calcium binding site 1 out of 1 in the Human Triose Phosphate Isomerase Q181P


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Triose Phosphate Isomerase Q181P within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca301 b:20.8 occ:1.00 O B:VAL226 2.6 13.5 1.0 O B:ALA221 2.7 16.4 1.0 O B:GLN223 2.7 15.2 1.0 O B:HOH419 2.7 34.5 1.0 O B:HOH442 2.8 38.5 1.0 C B:VAL226 3.8 12.1 1.0 C B:ALA221 3.8 15.2 1.0 C B:GLN223 3.8 15.2 1.0 H B:VAL226 3.9 14.1 1.0 HA B:PRO224 3.9 18.7 1.0 HD3 B:LYS247 4.0 38.1 1.0 HA B:ASP227 4.1 13.3 1.0 HZ3 B:LYS247 4.2 42.6 1.0 HB B:VAL226 4.2 14.6 1.0 HE3 B:LYS247 4.2 40.9 1.0 HA B:SER222 4.3 19.4 1.0 N B:GLN223 4.3 14.9 1.0 C B:SER222 4.3 16.3 1.0 H B:GLN223 4.3 17.9 1.0 HA B:ALA221 4.3 18.0 1.0 O B:PRO224 4.4 16.3 1.0 N B:VAL226 4.4 11.8 1.0 C B:PRO224 4.5 14.3 1.0 CA B:PRO224 4.5 15.6 1.0 CA B:VAL226 4.6 11.8 1.0 HE1 B:PHE6 4.6 22.3 1.0 O B:HOH531 4.6 23.3 1.0 CA B:SER222 4.6 16.2 1.0 N B:PRO224 4.6 15.1 1.0 N B:SER222 4.6 16.0 1.0 O B:SER222 4.7 17.5 1.0 CA B:ALA221 4.7 15.0 1.0 CA B:GLN223 4.7 15.6 1.0 N B:ASP227 4.7 11.0 1.0 CD B:LYS247 4.8 31.7 1.0 O B:HOH602 4.8 39.8 1.0 CE B:LYS247 4.8 34.1 1.0 HD1 B:PHE6 4.8 20.5 1.0 CA B:ASP227 4.8 11.1 1.0 CB B:VAL226 4.8 12.1 1.0 OD1 B:ASP227 4.9 15.8 1.0 NZ B:LYS247 4.9 35.5 1.0 HG12 B:VAL226 4.9 15.4 1.0 HB1 B:ALA221 5.0 19.1 1.0

A.P.Vandemark, S.L.Hrizo, S.L.Eicher, J.Kowalski, T.D.Myers, M.R.Pfeifer, K.N.Riley, D.D.Koeberl, M.J.Palladino. Itavastatin and Resveratrol Increase Triosephosphate Isomerase Protein in A Newly Identified Variant of Tpi Deficiency. Dis Model Mech V. 15 2022.
ISSN: ISSN 1754-8411
PubMed: 35315486
DOI: 10.1242/DMM.049261