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Calcium in PDB 7reg: DFRA1 Complexed with Nadph and 4'-Chloro-3'-(4-(2,4-Diamino-6- Ethylpyrimidin-5-Yl)But-3-Yn-2-Yl)-[1,1'-Biphenyl]-4-Carboxamide (UCP1228)Enzymatic activity of DFRA1 Complexed with Nadph and 4'-Chloro-3'-(4-(2,4-Diamino-6- Ethylpyrimidin-5-Yl)But-3-Yn-2-Yl)-[1,1'-Biphenyl]-4-Carboxamide (UCP1228)
All present enzymatic activity of DFRA1 Complexed with Nadph and 4'-Chloro-3'-(4-(2,4-Diamino-6- Ethylpyrimidin-5-Yl)But-3-Yn-2-Yl)-[1,1'-Biphenyl]-4-Carboxamide (UCP1228):
1.5.1.3; Protein crystallography data
The structure of DFRA1 Complexed with Nadph and 4'-Chloro-3'-(4-(2,4-Diamino-6- Ethylpyrimidin-5-Yl)But-3-Yn-2-Yl)-[1,1'-Biphenyl]-4-Carboxamide (UCP1228), PDB code: 7reg
was solved by
M.N.Lombardo,
D.L.Wright,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7reg:
The structure of DFRA1 Complexed with Nadph and 4'-Chloro-3'-(4-(2,4-Diamino-6- Ethylpyrimidin-5-Yl)But-3-Yn-2-Yl)-[1,1'-Biphenyl]-4-Carboxamide (UCP1228) also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the DFRA1 Complexed with Nadph and 4'-Chloro-3'-(4-(2,4-Diamino-6- Ethylpyrimidin-5-Yl)But-3-Yn-2-Yl)-[1,1'-Biphenyl]-4-Carboxamide (UCP1228)
(pdb code 7reg). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the DFRA1 Complexed with Nadph and 4'-Chloro-3'-(4-(2,4-Diamino-6- Ethylpyrimidin-5-Yl)But-3-Yn-2-Yl)-[1,1'-Biphenyl]-4-Carboxamide (UCP1228), PDB code: 7reg: Calcium binding site 1 out of 1 in 7regGo back to Calcium Binding Sites List in 7reg
Calcium binding site 1 out
of 1 in the DFRA1 Complexed with Nadph and 4'-Chloro-3'-(4-(2,4-Diamino-6- Ethylpyrimidin-5-Yl)But-3-Yn-2-Yl)-[1,1'-Biphenyl]-4-Carboxamide (UCP1228)
Mono view Stereo pair view
Reference:
J.Krucinska,
M.N.Lombardo,
H.Erlandsen,
A.Estrada,
D.Si,
K.Viswanathan,
D.L.Wright.
Structure-Guided Functional Studies of Plasmid-Encoded Dihydrofolate Reductases Reveal A Common Mechanism of Trimethoprim Resistance in Gram-Negative Pathogens. Commun Biol V. 5 459 2022.
Page generated: Tue Apr 4 18:36:24 2023
ISSN: ESSN 2399-3642 PubMed: 35562546 DOI: 10.1038/S42003-022-03384-Y |
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