Calcium in PDB 7uac: Human Pro-Meprin Alpha (Zymogen State)

All present enzymatic activity of Human Pro-Meprin Alpha (Zymogen State):
3.4.24.18;

The structure of Human Pro-Meprin Alpha (Zymogen State) also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Calcium atom in the Human Pro-Meprin Alpha (Zymogen State) (pdb code 7uac). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Human Pro-Meprin Alpha (Zymogen State), PDB code: 7uac:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Human Pro-Meprin Alpha (Zymogen State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Pro-Meprin Alpha (Zymogen State) within 5.0Å range: probe atom residue distance (Å) B Occ H:Ca701 b:79.3 occ:1.00 OD1 H:ASP288 2.3 81.2 1.0 OD1 H:ASP285 2.3 84.6 1.0 OD2 H:ASP285 2.4 84.6 1.0 O H:THR287 2.5 82.4 1.0 O H:GLY282 2.7 82.9 1.0 CG H:ASP285 2.7 84.6 1.0 C H:THR287 3.5 82.4 1.0 CG H:ASP288 3.6 81.2 1.0 C H:GLY282 3.8 82.9 1.0 CA H:ASP288 4.2 81.2 1.0 CB H:ASP285 4.2 84.6 1.0 N H:ASP288 4.2 81.2 1.0 OD2 H:ASP288 4.4 81.2 1.0 CB H:ASP288 4.4 81.2 1.0 N H:GLY282 4.5 82.9 1.0 CA H:THR287 4.5 82.4 1.0 CB H:GLN281 4.6 78.8 1.0 N H:THR287 4.6 82.4 1.0 N H:THR283 4.6 86.2 1.0 CA H:THR283 4.7 86.2 1.0 C H:GLN281 4.7 78.8 1.0 OE1 H:GLN281 4.7 78.8 1.0 CA H:GLY282 4.7 82.9 1.0 N H:LEU329 4.8 78.4 1.0 O H:LEU329 4.8 78.4 1.0 C H:ASP285 5.0 84.6 1.0

Calcium binding site 2 out of 2 in the Human Pro-Meprin Alpha (Zymogen State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human Pro-Meprin Alpha (Zymogen State) within 5.0Å range: probe atom residue distance (Å) B Occ H:Ca703 b:83.0 occ:1.00 O H:TYR313 2.4 80.7 1.0 OE1 H:GLU272 2.4 84.2 1.0 OD1 H:ASP422 2.4 81.8 1.0 O H:THR270 2.4 82.2 1.0 OD1 H:ASP301 2.5 84.3 1.0 OD2 H:ASP301 2.5 84.3 1.0 OG1 H:THR303 2.5 82.9 1.0 OD2 H:ASP422 2.6 81.8 1.0 CG H:ASP301 2.8 84.3 1.0 CG H:ASP422 2.8 81.8 1.0 C H:TYR313 3.4 80.7 1.0 CB H:THR303 3.4 82.9 1.0 C H:THR270 3.6 82.2 1.0 CD H:GLU272 3.6 84.2 1.0 N H:TYR313 3.7 80.7 1.0 CA H:TYR313 4.1 80.7 1.0 N H:THR303 4.1 82.9 1.0 CB H:ASP422 4.2 81.8 1.0 CB H:ASP301 4.2 84.3 1.0 CG H:GLU272 4.3 84.2 1.0 CA H:THR270 4.3 82.2 1.0 N H:PHE314 4.3 79.1 1.0 CA H:THR303 4.4 82.9 1.0 CG2 H:THR303 4.5 82.9 1.0 CB H:THR270 4.5 82.2 1.0 OE2 H:GLU272 4.5 84.2 1.0 N H:PHE271 4.6 81.5 1.0 C H:GLY312 4.6 83.4 1.0 CB H:PHE271 4.6 81.5 1.0 CA H:PHE314 4.7 79.1 1.0 CB H:TYR313 4.8 80.7 1.0 OD1 H:ASP423 4.8 84.0 1.0 CA H:GLY312 4.9 83.4 1.0 CA H:PHE271 4.9 81.5 1.0 C H:PHE271 4.9 81.5 1.0 N H:GLU272 5.0 84.2 1.0

C.Bayly-Jones, C.J.Lupton, C.Fritz, H.Venugopal, D.Ramsbeck, M.Wermann, C.Jager, A.De Marco, S.Schilling, D.Schlenzig, J.C.Whisstock. Helical Ultrastructure of the Metalloprotease Meprin Alpha in Complex with A Small Molecule Inhibitor. Nat Commun V. 13 6178 2022.
ISSN: ESSN 2041-1723
PubMed: 36261433
DOI: 10.1038/S41467-022-33893-7