Calcium in PDB 7uae: Human Meprin Alpha (Active State)

All present enzymatic activity of Human Meprin Alpha (Active State):
3.4.24.18;

The structure of Human Meprin Alpha (Active State) also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Calcium atom in the Human Meprin Alpha (Active State) (pdb code 7uae). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Human Meprin Alpha (Active State), PDB code: 7uae:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Human Meprin Alpha (Active State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Meprin Alpha (Active State) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca701 b:68.8 occ:1.00 OD1 A:ASP288 2.3 70.3 1.0 OD1 A:ASP285 2.3 72.2 1.0 OD2 A:ASP285 2.4 72.2 1.0 O A:THR287 2.5 71.7 1.0 O A:GLY282 2.5 72.8 1.0 CG A:ASP285 2.7 72.2 1.0 C A:THR287 3.5 71.7 1.0 CG A:ASP288 3.5 70.3 1.0 C A:GLY282 3.6 72.8 1.0 CA A:ASP288 4.1 70.3 1.0 N A:ASP288 4.1 70.3 1.0 CB A:ASP285 4.2 72.2 1.0 N A:GLY282 4.4 72.8 1.0 CB A:ASP288 4.4 70.3 1.0 OD2 A:ASP288 4.4 70.3 1.0 N A:THR287 4.5 71.7 1.0 N A:THR283 4.5 75.5 1.0 CB A:GLN281 4.5 68.3 1.0 CA A:THR287 4.5 71.7 1.0 CA A:GLY282 4.5 72.8 1.0 CA A:THR283 4.6 75.5 1.0 OE1 A:GLN281 4.6 68.3 1.0 C A:GLN281 4.6 68.3 1.0 O A:LEU329 4.8 65.9 1.0 N A:LEU329 4.8 65.9 1.0 O A:GLN281 5.0 68.3 1.0

Calcium binding site 2 out of 2 in the Human Meprin Alpha (Active State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human Meprin Alpha (Active State) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca703 b:68.0 occ:1.00 OE2 A:GLU272 2.3 72.1 1.0 O A:TYR313 2.3 69.4 1.0 OG1 A:THR303 2.4 69.1 1.0 OD1 A:ASP422 2.4 69.4 1.0 OD2 A:ASP422 2.5 69.4 1.0 O A:THR270 2.5 70.5 1.0 OD1 A:ASP301 2.6 71.2 1.0 OD2 A:ASP301 2.6 71.2 1.0 CG A:ASP422 2.7 69.4 1.0 CG A:ASP301 2.9 71.2 1.0 CB A:THR303 3.3 69.1 1.0 C A:TYR313 3.3 69.4 1.0 CD A:GLU272 3.5 72.1 1.0 C A:THR270 3.6 70.5 1.0 N A:TYR313 3.8 69.4 1.0 N A:THR303 4.0 69.1 1.0 CA A:TYR313 4.1 69.4 1.0 CB A:ASP422 4.2 69.4 1.0 CG A:GLU272 4.2 72.1 1.0 CA A:THR303 4.2 69.1 1.0 N A:PHE314 4.3 68.8 1.0 CA A:THR270 4.4 70.5 1.0 CG2 A:THR303 4.4 69.1 1.0 OE1 A:GLU272 4.4 72.1 1.0 CB A:ASP301 4.4 71.2 1.0 CB A:THR270 4.6 70.5 1.0 CA A:PHE314 4.6 68.8 1.0 N A:PHE271 4.7 69.7 1.0 CB A:PHE271 4.7 69.7 1.0 CB A:TYR313 4.8 69.4 1.0 C A:GLY312 4.8 71.1 1.0 OD1 A:ASP423 4.9 71.2 1.0 N A:HIS302 4.9 69.4 1.0 C A:PHE271 4.9 69.7 1.0 CA A:PHE271 5.0 69.7 1.0

C.Bayly-Jones, C.J.Lupton, C.Fritz, H.Venugopal, D.Ramsbeck, M.Wermann, C.Jager, A.De Marco, S.Schilling, D.Schlenzig, J.C.Whisstock. Helical Ultrastructure of the Metalloprotease Meprin Alpha in Complex with A Small Molecule Inhibitor. Nat Commun V. 13 6178 2022.
ISSN: ESSN 2041-1723
PubMed: 36261433
DOI: 10.1038/S41467-022-33893-7