Calcium in PDB 7uhf: Human L-Type Voltage-Gated Calcium Channel CAV1.3 in the Presence of Cinnarizine at 3.1 Angstrom Resolution

The binding sites of Calcium atom in the Human L-Type Voltage-Gated Calcium Channel CAV1.3 in the Presence of Cinnarizine at 3.1 Angstrom Resolution (pdb code 7uhf). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Human L-Type Voltage-Gated Calcium Channel CAV1.3 in the Presence of Cinnarizine at 3.1 Angstrom Resolution, PDB code: 7uhf:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Human L-Type Voltage-Gated Calcium Channel CAV1.3 in the Presence of Cinnarizine at 3.1 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human L-Type Voltage-Gated Calcium Channel CAV1.3 in the Presence of Cinnarizine at 3.1 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2203 b:22.9 occ:1.00 OE2 A:GLU1101 2.5 18.2 1.0 OE2 A:GLU364 2.5 16.2 1.0 OE1 A:GLU1101 2.5 18.2 1.0 OE1 A:GLU705 2.6 15.9 1.0 CD A:GLU1101 2.9 18.2 1.0 CD A:GLU364 3.4 16.2 1.0 OE1 A:GLU364 3.6 16.2 1.0 CD A:GLU705 3.7 15.9 1.0 O A:GLU1406 3.8 17.5 1.0 O A:GLY1405 3.9 15.5 1.0 OE2 A:GLU705 4.1 15.9 1.0 CG A:GLU1101 4.4 18.2 1.0 O A:MET363 4.5 18.5 1.0 C A:GLU1406 4.6 17.5 1.0 CA A:GLU1406 4.7 17.5 1.0 CA A:GLU705 4.7 15.9 1.0 O A:PHE1100 4.8 17.1 1.0 CG A:GLU364 4.8 16.2 1.0 N A:ASP706 5.0 15.7 1.0 CG A:GLU705 5.0 15.9 1.0

Calcium binding site 2 out of 2 in the Human L-Type Voltage-Gated Calcium Channel CAV1.3 in the Presence of Cinnarizine at 3.1 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human L-Type Voltage-Gated Calcium Channel CAV1.3 in the Presence of Cinnarizine at 3.1 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1203 b:37.4 occ:1.00 OG D:SER263 2.5 15.0 1.0 OG1 D:THR331 2.5 23.9 1.0 OD2 A:ASP153 2.6 18.0 1.0 OG D:SER261 2.8 18.0 1.0 CG A:ASP153 3.5 18.0 1.0 CB D:SER263 3.5 15.0 1.0 OD1 A:ASP153 3.7 18.0 1.0 CB D:SER261 3.7 18.0 1.0 CB D:THR331 3.8 23.9 1.0 OD2 D:ASP259 4.2 20.8 1.0 N D:SER263 4.3 15.0 1.0 CG2 D:THR331 4.4 23.9 1.0 OD1 D:ASP363 4.4 16.7 1.0 CA D:SER263 4.5 15.0 1.0 O D:GLY364 4.6 16.0 1.0 OD2 D:ASP363 4.8 16.7 1.0 CB A:ASP153 4.9 18.0 1.0 CA D:THR331 4.9 23.9 1.0 N D:THR331 4.9 23.9 1.0

X.Yao, S.Gao, N.Yan. Structural Basis For Pore Blockade of Human Voltage-Gated Calcium Channel Ca V 1.3 By Motion Sickness Drug Cinnarizine. Cell Res. V. 32 946 2022.
ISSN: ISSN 1001-0602
PubMed: 35477996
DOI: 10.1038/S41422-022-00663-5