Calcium in PDB 7wdb: Human TRPC5 Channel in Complex with Riluzole

The structure of Human TRPC5 Channel in Complex with Riluzole also contains other interesting chemical elements:

Fluorine	(F)	12 atoms
Zinc	(Zn)	4 atoms

The binding sites of Calcium atom in the Human TRPC5 Channel in Complex with Riluzole (pdb code 7wdb). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Human TRPC5 Channel in Complex with Riluzole, PDB code: 7wdb:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca904 b:83.4 occ:1.00 OD1 A:ASN436 2.6 85.6 1.0 OD2 A:ASP439 2.7 87.1 1.0 OE1 A:GLU418 3.0 92.5 1.0 OE1 A:GLU421 3.4 102.9 1.0 NH2 A:ARG492 3.7 71.5 1.0 CD A:GLU418 3.8 92.0 1.0 OE2 A:GLU418 3.8 92.6 1.0 CG A:ASN436 3.8 87.3 1.0 CG A:ASP439 3.9 80.8 1.0 N1 A:657905 4.0 90.9 1.0 CD A:GLU421 4.3 110.6 1.0 OE2 A:GLU421 4.3 112.8 1.0 OD2 A:ASP433 4.4 102.5 1.0 CB A:ASP439 4.6 73.1 1.0 CA A:ASN436 4.6 76.1 1.0 ND2 A:ASN436 4.6 94.7 1.0 C3 A:657905 4.7 85.3 1.0 C2 A:657905 4.7 82.1 1.0 N A:ASN436 4.8 78.2 1.0 CB A:ASN436 4.8 80.4 1.0 OD1 A:ASP439 4.8 80.6 1.0 CZ A:ARG492 5.0 66.4 1.0

Calcium binding site 2 out of 4 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca904 b:83.4 occ:1.00 OD1 B:ASN436 2.6 85.6 1.0 OD2 B:ASP439 2.7 87.1 1.0 OE1 B:GLU418 3.0 92.5 1.0 OE1 B:GLU421 3.4 102.9 1.0 NH2 B:ARG492 3.7 71.5 1.0 CD B:GLU418 3.8 92.0 1.0 OE2 B:GLU418 3.8 92.6 1.0 CG B:ASN436 3.8 87.3 1.0 CG B:ASP439 3.9 80.8 1.0 N1 B:657905 4.0 90.9 1.0 CD B:GLU421 4.3 110.6 1.0 OE2 B:GLU421 4.3 112.8 1.0 OD2 B:ASP433 4.4 102.5 1.0 CB B:ASP439 4.6 73.1 1.0 CA B:ASN436 4.6 76.1 1.0 ND2 B:ASN436 4.6 94.7 1.0 C3 B:657905 4.7 85.3 1.0 C2 B:657905 4.7 82.1 1.0 N B:ASN436 4.8 78.2 1.0 CB B:ASN436 4.8 80.4 1.0 OD1 B:ASP439 4.8 80.6 1.0 CZ B:ARG492 5.0 66.4 1.0

Calcium binding site 3 out of 4 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca904 b:83.4 occ:1.00 OD1 C:ASN436 2.6 85.6 1.0 OD2 C:ASP439 2.7 87.1 1.0 OE1 C:GLU418 3.0 92.5 1.0 OE1 C:GLU421 3.4 102.9 1.0 NH2 C:ARG492 3.7 71.5 1.0 CD C:GLU418 3.8 92.0 1.0 OE2 C:GLU418 3.8 92.6 1.0 CG C:ASN436 3.8 87.3 1.0 CG C:ASP439 3.9 80.8 1.0 N1 C:657905 4.0 90.9 1.0 CD C:GLU421 4.3 110.6 1.0 OE2 C:GLU421 4.3 112.8 1.0 OD2 C:ASP433 4.4 102.5 1.0 CB C:ASP439 4.6 73.1 1.0 CA C:ASN436 4.6 76.1 1.0 ND2 C:ASN436 4.6 94.7 1.0 C3 C:657905 4.7 85.3 1.0 C2 C:657905 4.7 82.1 1.0 N C:ASN436 4.8 78.2 1.0 CB C:ASN436 4.8 80.4 1.0 OD1 C:ASP439 4.8 80.6 1.0 CZ C:ARG492 5.0 66.4 1.0

Calcium binding site 4 out of 4 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca904 b:83.4 occ:1.00 OD1 D:ASN436 2.6 85.6 1.0 OD2 D:ASP439 2.7 87.1 1.0 OE1 D:GLU418 3.0 92.5 1.0 OE1 D:GLU421 3.4 102.9 1.0 NH2 D:ARG492 3.7 71.5 1.0 CD D:GLU418 3.8 92.0 1.0 OE2 D:GLU418 3.8 92.6 1.0 CG D:ASN436 3.8 87.3 1.0 CG D:ASP439 3.9 80.8 1.0 N1 D:657905 4.0 90.9 1.0 CD D:GLU421 4.3 110.6 1.0 OE2 D:GLU421 4.3 112.8 1.0 OD2 D:ASP433 4.4 102.5 1.0 CB D:ASP439 4.6 73.1 1.0 CA D:ASN436 4.6 76.1 1.0 ND2 D:ASN436 4.6 94.7 1.0 C3 D:657905 4.7 85.3 1.0 C2 D:657905 4.7 82.1 1.0 N D:ASN436 4.8 78.2 1.0 CB D:ASN436 4.8 80.4 1.0 OD1 D:ASP439 4.8 80.6 1.0 CZ D:ARG492 5.0 66.4 1.0

Y.Yang, M.Wei, L.Chen. Structural Identification of Riluzole-Binding Site on Human TRPC5. Cell Discov V. 8 67 2022.
ISSN: ESSN 2056-5968
PubMed: 35821012
DOI: 10.1038/S41421-022-00410-5