Calcium in PDB 7wre: Mouse TRPM8 in Lipid Nanodiscs in the Presence of Calcium and Icilin

The binding sites of Calcium atom in the Mouse TRPM8 in Lipid Nanodiscs in the Presence of Calcium and Icilin (pdb code 7wre). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Mouse TRPM8 in Lipid Nanodiscs in the Presence of Calcium and Icilin, PDB code: 7wre:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Mouse TRPM8 in Lipid Nanodiscs in the Presence of Calcium and Icilin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Mouse TRPM8 in Lipid Nanodiscs in the Presence of Calcium and Icilin within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1201 b:83.4 occ:1.00 OE2 A:GLU782 2.5 81.3 1.0 OD1 A:ASN799 2.5 76.8 1.0 OD2 A:ASP802 3.0 63.0 1.0 OE1 A:GLN785 3.0 97.4 1.0 OE1 A:GLU782 3.1 81.3 1.0 CD A:GLU782 3.2 81.3 1.0 NH1 A:ARG842 3.6 39.8 1.0 CD A:GLN785 3.7 97.4 1.0 NE2 A:GLN785 3.7 97.4 1.0 CG A:ASN799 3.7 76.8 1.0 CG A:ASP802 4.0 63.0 1.0 NH2 A:ARG842 4.4 39.8 1.0 CZ A:ARG842 4.5 39.8 1.0 ND2 A:ASN799 4.6 76.8 1.0 CE1 A:TYR793 4.6 96.6 1.0 OH A:TYR793 4.7 96.6 1.0 CG A:GLU782 4.7 81.3 1.0 CB A:ASN799 4.7 76.8 1.0 CA A:ASN799 4.7 76.8 1.0 CB A:ASP802 4.8 63.0 1.0 OD1 A:ASP802 4.8 63.0 1.0

Calcium binding site 2 out of 4 in the Mouse TRPM8 in Lipid Nanodiscs in the Presence of Calcium and Icilin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Mouse TRPM8 in Lipid Nanodiscs in the Presence of Calcium and Icilin within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1201 b:82.4 occ:1.00 OD1 B:ASN799 2.5 76.3 1.0 OE2 B:GLU782 2.5 80.9 1.0 OD2 B:ASP802 3.0 62.8 1.0 OE1 B:GLN785 3.0 96.4 1.0 OE1 B:GLU782 3.1 80.9 1.0 CD B:GLU782 3.2 80.9 1.0 NH1 B:ARG842 3.6 39.9 1.0 CD B:GLN785 3.7 96.4 1.0 NE2 B:GLN785 3.7 96.4 1.0 CG B:ASN799 3.7 76.3 1.0 CG B:ASP802 4.0 62.8 1.0 NH2 B:ARG842 4.4 39.9 1.0 CZ B:ARG842 4.5 39.9 1.0 ND2 B:ASN799 4.6 76.3 1.0 CE1 B:TYR793 4.6 95.6 1.0 OH B:TYR793 4.7 95.6 1.0 CG B:GLU782 4.7 80.9 1.0 CB B:ASN799 4.7 76.3 1.0 CA B:ASN799 4.7 76.3 1.0 CB B:ASP802 4.8 62.8 1.0 OD1 B:ASP802 4.8 62.8 1.0

Calcium binding site 3 out of 4 in the Mouse TRPM8 in Lipid Nanodiscs in the Presence of Calcium and Icilin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Mouse TRPM8 in Lipid Nanodiscs in the Presence of Calcium and Icilin within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1201 b:80.8 occ:1.00 OE2 C:GLU782 2.5 81.1 1.0 OD1 C:ASN799 2.5 76.3 1.0 OD2 C:ASP802 3.0 63.1 1.0 OE1 C:GLN785 3.0 96.9 1.0 OE1 C:GLU782 3.1 81.1 1.0 CD C:GLU782 3.2 81.1 1.0 NH1 C:ARG842 3.6 40.1 1.0 CD C:GLN785 3.7 96.9 1.0 NE2 C:GLN785 3.7 96.9 1.0 CG C:ASN799 3.7 76.3 1.0 CG C:ASP802 4.0 63.1 1.0 NH2 C:ARG842 4.4 40.1 1.0 CZ C:ARG842 4.5 40.1 1.0 ND2 C:ASN799 4.6 76.3 1.0 CE1 C:TYR793 4.6 95.7 1.0 OH C:TYR793 4.7 95.7 1.0 CG C:GLU782 4.7 81.1 1.0 CB C:ASN799 4.7 76.3 1.0 CA C:ASN799 4.7 76.3 1.0 CB C:ASP802 4.8 63.1 1.0 OD1 C:ASP802 4.8 63.1 1.0

Calcium binding site 4 out of 4 in the Mouse TRPM8 in Lipid Nanodiscs in the Presence of Calcium and Icilin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Mouse TRPM8 in Lipid Nanodiscs in the Presence of Calcium and Icilin within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1201 b:81.0 occ:1.00 OE2 D:GLU782 2.5 80.8 1.0 OD1 D:ASN799 2.5 75.7 1.0 OD2 D:ASP802 3.0 62.1 1.0 OE1 D:GLN785 3.0 97.1 1.0 OE1 D:GLU782 3.1 80.8 1.0 CD D:GLU782 3.2 80.8 1.0 NH1 D:ARG842 3.6 39.7 1.0 CD D:GLN785 3.7 97.1 1.0 NE2 D:GLN785 3.7 97.1 1.0 CG D:ASN799 3.7 75.7 1.0 CG D:ASP802 4.0 62.1 1.0 NH2 D:ARG842 4.4 39.7 1.0 CZ D:ARG842 4.5 39.7 1.0 ND2 D:ASN799 4.6 75.7 1.0 CE1 D:TYR793 4.6 95.7 1.0 OH D:TYR793 4.7 95.7 1.0 CG D:GLU782 4.7 80.8 1.0 CB D:ASN799 4.7 75.7 1.0 CA D:ASN799 4.7 75.7 1.0 CB D:ASP802 4.8 62.1 1.0 OD1 D:ASP802 4.8 62.1 1.0

C.Zhao, Y.Xie, L.Xu, F.Ye, X.Xu, W.Yang, F.Yang, J.Guo. Structures of A Mammalian TRPM8 in Closed State. Nat Commun V. 13 3113 2022.
ISSN: ESSN 2041-1723
PubMed: 35662242
DOI: 10.1038/S41467-022-30919-Y