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Calcium in PDB 7x1o: Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95

Enzymatic activity of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95

All present enzymatic activity of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95:
6.1.1.15; 6.1.1.17;

Protein crystallography data

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95, PDB code: 7x1o was solved by Y.Manickam, P.Babbar, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 33.52 / 2.04
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 72.03, 93.73, 87.09, 90, 109.62, 90
R / Rfree (%) 19.4 / 23.7

Other elements in 7x1o:

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95 also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms
Zinc (Zn) 5 atoms
Bromine (Br) 4 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95 (pdb code 7x1o). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95, PDB code: 7x1o:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in 7x1o

Go back to Calcium Binding Sites List in 7x1o
Calcium binding site 1 out of 4 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1906

b:108.5
occ:1.00
 O B:HOH2073 2.6 79.1 1.0
O A:HOH2059 3.6 80.2 1.0
OE2 A:GLU1036 4.7 54.6 1.0
OE1 A:GLU1036 4.7 63.9 1.0

Calcium binding site 2 out of 4 in 7x1o

Go back to Calcium Binding Sites List in 7x1o
Calcium binding site 2 out of 4 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca1905

b:115.2
occ:1.00
 OE2 B:GLU1264 2.3 100.2 1.0
CD B:GLU1264 3.3 100.2 1.0
OE1 B:GLU1264 3.5 108.2 1.0
CG B:GLU1264 4.6 91.3 1.0

Calcium binding site 3 out of 4 in 7x1o

Go back to Calcium Binding Sites List in 7x1o
Calcium binding site 3 out of 4 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca1906

b:104.1
occ:1.00
 O B:HOH2076 3.3 74.5 1.0
OE1 B:GLU1100 4.1 80.8 1.0
OE2 B:GLU1100 4.5 72.7 1.0
CD B:GLU1100 4.7 73.2 1.0
OE1 B:GLU1154 4.7 70.4 1.0
OE2 B:GLU1154 4.8 74.5 1.0
CE1 B:PHE1097 4.9 60.0 1.0

Calcium binding site 4 out of 4 in 7x1o

Go back to Calcium Binding Sites List in 7x1o
Calcium binding site 4 out of 4 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with Double Inhibitors Hf and L95 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca1907

b:93.0
occ:0.89
 OE1 B:GLU1114 2.6 88.3 1.0
OE1 B:GLN1084 3.8 75.7 1.0
CD B:GLU1114 3.8 81.4 1.0
O B:ALA1113 4.5 56.5 1.0
OE2 B:GLU1114 4.6 86.3 1.0
CD B:PRO1115 4.7 61.9 1.0
CG B:GLU1114 4.8 74.8 1.0
CD B:GLN1084 4.9 74.4 1.0
CA B:GLU1114 4.9 61.4 1.0

Reference:

Y.Manickam, P.Babbar, A.Sharma. Crystal Structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) with Double Inhibitors (Hf and L95) To Be Published.
Page generated: Fri Jul 19 05:54:55 2024

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