Calcium in PDB 7xvr: Structure of Neuraminidase From Influenza B-Like Viruses Derived From Spiny Eel

All present enzymatic activity of Structure of Neuraminidase From Influenza B-Like Viruses Derived From Spiny Eel:
3.2.1.18;

The structure of Structure of Neuraminidase From Influenza B-Like Viruses Derived From Spiny Eel, PDB code: 7xvr was solved by Y.Chai, F.Gao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.56 / 2.40
Space group	I 4
Cell size a, b, c (Å), α, β, γ (°)	126.513, 126.513, 111.173, 90, 90, 90
R / Rfree (%)	15.5 / 19.7

The binding sites of Calcium atom in the Structure of Neuraminidase From Influenza B-Like Viruses Derived From Spiny Eel (pdb code 7xvr). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Structure of Neuraminidase From Influenza B-Like Viruses Derived From Spiny Eel, PDB code: 7xvr:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Structure of Neuraminidase From Influenza B-Like Viruses Derived From Spiny Eel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Neuraminidase From Influenza B-Like Viruses Derived From Spiny Eel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca500 b:35.8 occ:1.00 O A:GLY351 2.5 39.1 1.0 O A:SER302 2.6 32.6 1.0 O A:ASP298 2.6 33.5 1.0 OD2 A:ASP329 2.9 31.7 1.0 O A:GLY349 3.1 44.8 1.0 C A:SER302 3.5 33.1 1.0 O A:HOH614 3.6 28.5 1.0 C A:GLY351 3.6 36.9 1.0 CG A:ASP329 3.7 34.8 1.0 C A:ASP298 3.9 32.4 1.0 C A:GLY349 4.0 45.0 1.0 CA A:GLY352 4.0 32.0 1.0 CA A:ALA303 4.1 33.8 1.0 N A:ALA303 4.1 33.6 1.0 CB A:ASP329 4.2 26.5 1.0 N A:GLY352 4.3 35.9 1.0 CA A:GLY349 4.5 41.5 1.0 N A:SER302 4.5 34.5 1.0 CA A:ASN299 4.6 36.1 1.0 C A:GLY350 4.6 36.2 1.0 OD1 A:ASP329 4.6 30.1 1.0 CA A:SER302 4.6 34.7 1.0 O A:GLY350 4.7 38.0 1.0 N A:GLY351 4.7 36.6 1.0 N A:ASN299 4.7 30.6 1.0 CA A:GLY351 4.8 34.4 1.0 C A:ASN299 4.8 35.5 1.0 CA A:ASP298 4.8 30.5 1.0 CB A:ASP298 4.8 30.4 1.0 O A:PRO331 4.9 35.5 1.0 O A:ASN299 4.9 41.3 1.0 N A:GLY350 4.9 43.6 1.0 N A:ASP298 4.9 26.9 1.0 C A:ALA303 5.0 32.0 1.0

Calcium binding site 2 out of 2 in the Structure of Neuraminidase From Influenza B-Like Viruses Derived From Spiny Eel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Neuraminidase From Influenza B-Like Viruses Derived From Spiny Eel within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca500 b:36.2 occ:1.00 O B:ASP298 2.5 32.3 1.0 O B:SER302 2.5 33.9 1.0 O B:GLY351 2.6 40.0 1.0 OD2 B:ASP329 2.9 32.0 1.0 O B:GLY349 3.0 44.6 1.0 C B:SER302 3.4 34.4 1.0 O B:HOH615 3.6 28.4 1.0 CG B:ASP329 3.7 33.0 1.0 C B:ASP298 3.7 30.9 1.0 C B:GLY351 3.8 35.9 1.0 C B:GLY349 3.9 43.5 1.0 CA B:ALA303 3.9 33.2 1.0 N B:ALA303 4.0 35.0 1.0 CB B:ASP329 4.1 29.4 1.0 CA B:GLY352 4.1 33.7 1.0 CA B:GLY349 4.3 38.8 1.0 N B:GLY352 4.4 33.1 1.0 N B:SER302 4.4 37.5 1.0 CA B:SER302 4.5 35.2 1.0 CA B:ASN299 4.6 34.5 1.0 OD1 B:ASP329 4.6 27.8 1.0 N B:ASN299 4.6 33.2 1.0 CA B:ASP298 4.6 31.4 1.0 CB B:ASP298 4.7 33.0 1.0 C B:ASN299 4.7 36.5 1.0 C B:ALA303 4.8 30.3 1.0 N B:ASP298 4.8 30.0 1.0 N B:GLY351 4.8 37.5 1.0 O B:PRO331 4.9 35.5 1.0 CA B:GLY351 4.9 37.5 1.0 C B:GLY350 4.9 45.1 1.0 N B:ALA300 4.9 35.6 1.0 N B:GLY350 5.0 50.3 1.0 CB B:ALA303 5.0 30.6 1.0

L.Li, Y.Chai, W.Peng, D.Li, L.Sun, G.F.Gao, J.Qi, H.Xiao, W.J.Liu, M.Von Itzstein, F.Gao. Structural and Inhibitor Sensitivity Analysis of Influenza B-Like Viral Neuraminidases Derived From Asiatic Toad and Spiny Eel. Proc.Natl.Acad.Sci.Usa V. 119 24119 2022.
ISSN: ESSN 1091-6490
PubMed: 36191180
DOI: 10.1073/PNAS.2210724119